Taurine deficiency as a driver of aging.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
09 06 2023
09 06 2023
Historique:
medline:
12
6
2023
pubmed:
8
6
2023
entrez:
8
6
2023
Statut:
ppublish
Résumé
Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.
Identifiants
pubmed: 37289866
doi: 10.1126/science.abn9257
pmc: PMC10630957
mid: NIHMS1908473
doi:
Substances chimiques
Taurine
1EQV5MLY3D
Telomerase
EC 2.7.7.49
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabn9257Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P30 AG013280
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD107574
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG066574
Pays : United States
Commentaires et corrections
Type : CommentIn
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