Sperm DNA fragmentation and its interaction with female factors.
DNA fragmentation
DNA repair
Oocyte
sperm
Journal
Fertility and sterility
ISSN: 1556-5653
Titre abrégé: Fertil Steril
Pays: United States
ID NLM: 0372772
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
31
05
2023
accepted:
01
06
2023
medline:
25
9
2023
pubmed:
9
6
2023
entrez:
8
6
2023
Statut:
ppublish
Résumé
High levels of sperm deoxyribonucleic acid (DNA) fragmentation have been associated with adverse reproductive outcomes, including low natural and assisted pregnancy rates, abnormal embryonic development, and recurrent pregnancy loss. These poor outcomes are likely caused by unrepaired DNA damage exceeding a critical repair threshold, adversely affecting normal embryo development. In these cases, DNA repair mechanisms of the oocyte may play a significant role in compensating for sperm DNA damage, preserving normal embryo development, and enhancing reproductive outcomes.
Identifiants
pubmed: 37290553
pii: S0015-0282(23)00590-3
doi: 10.1016/j.fertnstert.2023.06.001
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
715-719Informations de copyright
Copyright © 2023 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.