Evaluation of electroretinography (ERG) parameters as a biomarker for ADHD.
Attention-deficit/hyperactivity disorder (ADHD)
Biomarker
Diagnostic
Electroretinogram (ERG)
Retina
Journal
Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617
Informations de publication
Date de publication:
20 12 2023
20 12 2023
Historique:
received:
30
01
2023
revised:
19
05
2023
accepted:
01
06
2023
medline:
7
9
2023
pubmed:
9
6
2023
entrez:
8
6
2023
Statut:
ppublish
Résumé
The retina is recognized as an accessible part of the brain due to their common embryonic origin. The electroretinogram (ERG) has proven to be a valuable tool for detecting schizophrenia and bipolarity. We therefore investigated its ability to detect ADHD. The cone and rod luminance response functions of the ERG were recorded in 26 ADHD subjects (17 women and 9 men) and 25 controls (16 women and 9 men). No significant differences were found between the mixed groups, but sexual dysmorphia was observed in the significant results. In males, a significant prolonged cone a-wave latency was observed in the ADHD group. In females, we observed a significant decrease in the cone a- and b-wave amplitudes and a trend for a prolonged cone b-wave latency as well as a higher scotopic mixed rod-cone a-wave in the ADHD group. The data obtained in this study show the potential of the ERG to detect ADHD, warranting further large-scale studies.
Sections du résumé
BACKGROUND
The retina is recognized as an accessible part of the brain due to their common embryonic origin. The electroretinogram (ERG) has proven to be a valuable tool for detecting schizophrenia and bipolarity. We therefore investigated its ability to detect ADHD.
METHODS
The cone and rod luminance response functions of the ERG were recorded in 26 ADHD subjects (17 women and 9 men) and 25 controls (16 women and 9 men).
RESULTS
No significant differences were found between the mixed groups, but sexual dysmorphia was observed in the significant results. In males, a significant prolonged cone a-wave latency was observed in the ADHD group. In females, we observed a significant decrease in the cone a- and b-wave amplitudes and a trend for a prolonged cone b-wave latency as well as a higher scotopic mixed rod-cone a-wave in the ADHD group.
CONCLUSION
The data obtained in this study show the potential of the ERG to detect ADHD, warranting further large-scale studies.
Identifiants
pubmed: 37290571
pii: S0278-5846(23)00093-3
doi: 10.1016/j.pnpbp.2023.110807
pii:
doi:
Substances chimiques
Biomarkers
0
ERG protein, human
0
Transcriptional Regulator ERG
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110807Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors attest that the material presented in this article is entirely original and has in no way appeared or been published in other submitted articles. The study is not a reanalysis of previously analyzed data and the data presented in this study were analyzed for the first time. No other previously published or submitted articles from this data set address a related topic. The manuscript has not been and is not posted on a website. All authors previously agreed with the content of the manuscript and with the order of authorship and the corresponding author will take responsibility for informing coauthors in a timely manner of editorial decisions, reviews received, changes made in response to editorial review, and content of revisions. None of the authors report any conflicts of interest in connection with this manuscript.