Total energy expenditure assessed by 24-h whole-room indirect calorimeter in patients with colorectal cancer: baseline findings from the PRIMe study.
body composition
cancer
energy expenditure
energy requirements
whole-body indirect calorimetry
whole-room indirect calorimetry
Journal
The American journal of clinical nutrition
ISSN: 1938-3207
Titre abrégé: Am J Clin Nutr
Pays: United States
ID NLM: 0376027
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
03
01
2023
revised:
19
05
2023
accepted:
05
06
2023
medline:
7
8
2023
pubmed:
9
6
2023
entrez:
8
6
2023
Statut:
ppublish
Résumé
Total energy expenditure (TEE) determines energy requirements, but objective data in patients with cancer are limited. We aimed to characterize TEE, investigate its predictors, and compare TEE with cancer-specific predicted energy requirements. This cross-sectional analysis included patients with stages II-IV colorectal cancer from the Protein Recommendation to Increase Muscle (PRIMe) trial. TEE was assessed by 24-h stay in a whole-room indirect calorimeter before dietary intervention and compared with cancer-specific predicted energy requirements (25-30 kcal/kg). Generalized linear models, paired-samples t tests, and Pearson correlation were applied. Thirty-one patients (56 ± 10 y; body mass index [BMI]: 27.9 ± 5.5 kg/m This is the largest study to assess TEE of patients with cancer using whole-room indirect calorimeter and highlights the need for improved assessment of energy requirements in this population. Energy requirements predicted using 30 kcal/kg overestimated TEE by 1.44 times in a controlled sedentary environment and TEE was outside of the predicted requirement range for most. Special considerations are warranted when determining TEE of patients with colorectal cancer, such as BMI, body composition, and tumor location. This is a baseline cross-sectional analysis from a clinical trial registered at clinicaltrials.gov as NCT02788955 (https://clinicaltrials.gov/ct2/show/NCT02788955).
Sections du résumé
BACKGROUND
Total energy expenditure (TEE) determines energy requirements, but objective data in patients with cancer are limited.
OBJECTIVES
We aimed to characterize TEE, investigate its predictors, and compare TEE with cancer-specific predicted energy requirements.
METHODS
This cross-sectional analysis included patients with stages II-IV colorectal cancer from the Protein Recommendation to Increase Muscle (PRIMe) trial. TEE was assessed by 24-h stay in a whole-room indirect calorimeter before dietary intervention and compared with cancer-specific predicted energy requirements (25-30 kcal/kg). Generalized linear models, paired-samples t tests, and Pearson correlation were applied.
RESULTS
Thirty-one patients (56 ± 10 y; body mass index [BMI]: 27.9 ± 5.5 kg/m
CONCLUSIONS
This is the largest study to assess TEE of patients with cancer using whole-room indirect calorimeter and highlights the need for improved assessment of energy requirements in this population. Energy requirements predicted using 30 kcal/kg overestimated TEE by 1.44 times in a controlled sedentary environment and TEE was outside of the predicted requirement range for most. Special considerations are warranted when determining TEE of patients with colorectal cancer, such as BMI, body composition, and tumor location. This is a baseline cross-sectional analysis from a clinical trial registered at clinicaltrials.gov as NCT02788955 (https://clinicaltrials.gov/ct2/show/NCT02788955).
Identifiants
pubmed: 37290740
pii: S0002-9165(23)65964-7
doi: 10.1016/j.ajcnut.2023.06.002
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT02788955']
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
422-432Informations de copyright
Copyright © 2023 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.