Using model systems to unravel host-Pseudomonas aeruginosa interactions.
Journal
Environmental microbiology
ISSN: 1462-2920
Titre abrégé: Environ Microbiol
Pays: England
ID NLM: 100883692
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
30
01
2023
accepted:
29
05
2023
medline:
4
10
2023
pubmed:
9
6
2023
entrez:
8
6
2023
Statut:
ppublish
Résumé
Using model systems in infection biology has led to the discoveries of many pathogen-encoded virulence factors and critical host immune factors to fight pathogenic infections. Studies of the remarkable Pseudomonas aeruginosa bacterium that infects and causes disease in hosts as divergent as humans and plants afford unique opportunities to shed new light on virulence strategies and host defence mechanisms. One of the rationales for using model systems as a discovery tool to characterise bacterial factors driving human infection outcomes is that many P. aeruginosa virulence factors are required for pathogenesis in diverse different hosts. On the other side, many host signalling components, such as the evolutionarily conserved mitogen-activated protein kinases, are involved in immune signalling in a diverse range of hosts. Some model organisms that have less complex immune systems also allow dissection of the direct impacts of innate immunity on host defence without the interference of adaptive immunity. In this review, we start with discussing the occurrence of P. aeruginosa in the environment and the ability of this bacterium to cause disease in various hosts as a natural opportunistic pathogen. We then summarise the use of some model systems to study host defence and P. aeruginosa virulence.
Identifiants
pubmed: 37290773
doi: 10.1111/1462-2920.16440
doi:
Substances chimiques
Virulence Factors
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1765-1784Subventions
Organisme : CIHR
ID : PJT165970
Pays : Canada
Informations de copyright
© 2023 The Authors. Environmental Microbiology published by Applied Microbiology International and John Wiley & Sons Ltd.
Références
Abd El-Ghany, W.A. (2021) Pseudomonas aeruginosa infection of avian origin: zoonosis and one health implications. Veterinary World, 14(8), 2155-2159. Available from: https://doi.org/10.14202/vetworld.2021.2155-2159
Alibaud, L., Köhler, T., Coudray, A., Prigent-Combaret, C., Bergeret, E., Perrin, J. et al. (2008) Pseudomonas aeruginosa virulence genes identified in a Dictyostelium host model. Cellular Microbiology, 10(3), 729-740. Available from: https://doi.org/10.1111/j.1462-5822.2007.01080.x
Altincicek, B., Linder, M., Linder, D., Preissner, K.T. & Vilcinskas, A. (2007) Microbial metalloproteinases mediate sensing of invading pathogens and activate innate immune responses in the lepidopteran model host Galleria mellonella. Infection and Immunity, 75(1), 175-183. Available from: https://doi.org/10.1128/IAI.01385-06
Andrejko, M. & Mizerska-Dudka, M. (2011) Elastase B of Pseudomonas aeruginosa stimulates the humoral immune response in the greater wax moth, Galleria mellonella. Journal of Invertebrate Pathology, 107(1), 16-26. Available from: https://doi.org/10.1016/j.jip.2010.12.015
Apidianakis, Y., Mindrinos, M.N., Xiao, W., Lau, G.W., Baldini, R.L., Davis, R.W. et al. (2005) Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression. Proceedings of the National Academy of Sciences of the United States of America, 102(7), 2573-2578. Available from: https://doi.org/10.1073/pnas.0409588102
Asai, T., Tena, G., Plotnikova, J., Willmann, M.R., Chiu, W.L., Gomez-Gomez, L. et al. (2002) MAP kinase signalling cascade in Arabidopsis innate immunity. Nature, 415(6875), 977-983. Available from: https://doi.org/10.1038/415977a
Ausubel, F.M. (2005) Are innate immune signaling pathways in plants and animals conserved? Nature Immunology, 6(10), 973-979. Available from: https://doi.org/10.1038/ni1253
Bachta, K.E.R., Allen, J.P., Cheung, B.H., Chiu, C.H. & Hauser, A.R. (2020) Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice. Nature Communications, 11(1), 543. Available from: https://doi.org/10.1038/s41467-020-14363-4
Bagnat, M., Navis, A., Herbstreith, S., Brand-Arzamendi, K., Curado, S., Gabriel, S. et al. (2010) Cse1l is a negative regulator of CFTR-dependent fluid secretion. Current Biology, 20(20), 1840-1845. Available from: https://doi.org/10.1016/j.cub.2010.09.012
Barbier, F., Andremont, A., Wolff, M. & Bouadma, L. (2013) Hospital-acquired pneumonia and ventilator-associated pneumonia: recent advances in epidemiology and management. Current Opinion in Pulmonary Medicine, 19(3), 216-228. Available from: https://doi.org/10.1097/MCP.0b013e32835f27be
Barceló, I.M., Torrens, G., Escobar-Salom, M., Jordana-Lluch, E., Capó-Bauzá, M.M., Ramón-Pallín, C. et al. (2022) Impact of peptidoglycan recycling blockade and expression of horizontally acquired β-lactamases on Pseudomonas aeruginosa virulence. Microbiology Spectrum, 10(1), e0201921. Available from: https://doi.org/10.1128/spectrum.02019-21
Barkal, L.J., Procknow, C.L., Álvarez-García, Y.R., Niu, M., Jiménez-Torres, J.A., Brockman-Schneider, R.A. et al. (2017) Microbial volatile communication in human organotypic lung models. Nature Communications, 8(1), 1770. Available from: https://doi.org/10.1038/s41467-017-01985-4
Bayes, H.K., Ritchie, N., Irvine, S. & Evans, T.J. (2016) A murine model of early Pseudomonas aeruginosa lung disease with transition to chronic infection. Scientific Reports, 6, 35838. Available from: https://doi.org/10.1038/srep35838
Belanger, C.R., Dostert, M., Blimkie, T.M., Huei-Yi Lee, A., Dhillon, B.K., Wu, B.C. et al. (2022) Surviving the host: microbial metabolic genes required for growth of Pseudomonas aeruginosa, in physiologically-relevant conditions. Frontiers in Microbiology, 13, 1055512. Available from: https://doi.org/10.3389/fmicb.2022.1055512
Bergamini, G., Perico, M.E., di Palma, S., Sabatini, D., Andreetta, F., Defazio, R. et al. (2021) Mouse pneumonia model by Acinetobacter baumannii multidrug resistant strains: comparison between intranasal inoculation, intratracheal instillation and oropharyngeal aspiration techniques. PLoS One, 16(12), e0260627. Available from: https://doi.org/10.1371/journal.pone.0260627
Bianconi, I., Jeukens, J., Freschi, L., Alcalá-Franco, B., Facchini, M., Boyle, B. et al. (2015) Comparative genomics and biological characterization of sequential Pseudomonas aeruginosa isolates from persistent airways infection. BMC Genomics, 16(1), 1105. Available from: https://doi.org/10.1186/s12864-015-2276-8
Bodey, G.P., Bolivar, R., Fainstein, V. & Jadeja, L. (1983) Infections caused by Pseudomonas aeruginosa. Reviews of Infectious Diseases, 5(2), 279-313 http://cid.oxfordjournals.org/
Boman, H., Nilsson, I. & Rasmuson, B. (1972) Inducible antibacterial Defence system in drosophila. Nature, 237, 232-235. Available from: https://doi.org/10.1038/237232a0
Boucher, J.C., Yu, H., Mudd, M.H. & Deretic, V. (1997) Mucoid Pseudomonas aeruginosa in cystic fibrosis: characterization of MUC mutations in clinical isolates and analysis of clearance in a mouse model of respiratory infection. Infection and Immunity, 65(9), 3838-3846. Available from: https://doi.org/10.1128/iai.65.9.3838-3846.1997
Brandenburg, K.S., Weaver, A.J., Karna, S.L.R., You, T., Chen, P., Stryk, S. et al. (2019) Formation of Pseudomonas aeruginosa biofilms in full-thickness scald burn wounds in rats. Scientific Reports, 9(1), 13627. Available from: https://doi.org/10.1038/s41598-019-50003-8
Brandenburg, K.S., Weaver, A.J., Qian, L., You, T., Chen, P., Karna, S.L.R. et al. (2019) Development of Pseudomonas aeruginosa biofilms in partial-thickness burn wounds using a Sprague-Dawley rat model. Journal of Burn Care and Research, 40(1), 44-57. Available from: https://doi.org/10.1093/jbcr/iry043
Bulet, P., Hetru, C. & Dimarcq, J.-L. (1999) Antimicrobial peptides in insects; structure and function. Developmental and Comparative Immunology, 16, 329-344.
Cafora, M., Brix, A., Forti, F., Loberto, N., Aureli, M., Briani, F. et al. (2021) Phages as immunomodulators and their promising use as anti-inflammatory agents in a cftr loss-of-function zebrafish model. Journal of Cystic Fibrosis, 20(6), 1046-1052. Available from: https://doi.org/10.1016/j.jcf.2020.11.017
Cafora, M., Deflorian, G., Forti, F., Ferrari, L., Binelli, G., Briani, F. et al. (2019) Phage therapy against Pseudomonas aeruginosa infections in a cystic fibrosis zebrafish model. Scientific Reports, 9(1), 1527. Available from: https://doi.org/10.1038/s41598-018-37636-x
Cafora, M., Forti, F., Briani, F., Ghisotti, D. & Pistocchi, A. (2020) Phage therapy application to counteract Pseudomonas aeruginosa infection in cystic fibrosis zebrafish embryos. Journal of Visualized Experiments: JoVE, 159, e61275. Available from: https://doi.org/10.3791/61275
Capo, F., Wilson, A. & Di Cara, F. (2019) The intestine of Drosophila melanogaster: an emerging versatile model system to study intestinal epithelial homeostasis and host-microbial interactions in humans. Microorganisms, 7(9), 336. Available from: https://doi.org/10.3390/microorganisms7090336
Cash, H.A., Woods, D.E., Mccullough, B., Johanson, W.G. & Bass, J.A. (1979) A rat model of chronic respiratory infection with Pseudomonas aeruginosa. American Review of Respiratory Disease, 119, 453-459.
Cezairliyan, B., Vinayavekhin, N., Grenfell-Lee, D., Yuen, G.J., Saghatelian, A. & Ausubel, F.M. (2013) Identification of Pseudomonas aeruginosa phenazines that kill Caenorhabditis elegans. PLoS Pathogens, 9(1), e1003101. Available from: https://doi.org/10.1371/journal.ppat.1003101
Chand, N.S., Lee, J.S., Clatworthy, A.E., Golas, A.J., Smith, R.S. & Hung, D.T. (2011) The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection. Journal of Bacteriology, 193(12), 2989-2999. Available from: https://doi.org/10.1128/JB.01546-10
Cheng, Z., Li, J.F., Niu, Y., Zhang, X.C., Woody, O.Z., Xiong, Y. et al. (2015) Pathogen-secreted proteases activate a novel plant immune pathway. Nature, 521(7551), 213-216. Available from: https://doi.org/10.1038/nature14243
Chinchilla, D., Bauer, Z., Regenass, M., Boller, T. & Felix, G. (2006) The Arabidopsis receptor kinase FLS2 binds flg22 and determines the specificity of flagellin perception. The Plant Cell, 18(2), 465-476. Available from: https://doi.org/10.1105/tpc.105.036574
Chinchilla, D., Zipfel, C., Robatzek, S., Kemmerling, B., Nürnberger, T., Jones, J.D. et al. (2007) A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence. Nature, 448(7152), 497-500. Available from: https://doi.org/10.1038/nature05999
Cigana, C., Lorè, N.I., Riva, C., de Fino, I., Spagnuolo, L., Sipione, B. et al. (2016) Tracking the immunopathological response to Pseudomonas aeruginosa during respiratory infections. Scientific Reports, 6, 21465. Available from: https://doi.org/10.1038/srep21465
Clara, F.M. (1930) A new bacterial leaf disease of tobacco in The Philippines. Phytopathology, 20(9), 691-706.
Clatworthy, A.E., Lee, J.S., Leibman, M., Kostun, Z., Davidson, A.J. & Hung, D.T. (2009) Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants. Infection and Immunity, 77(4), 1293-1303. Available from: https://doi.org/10.1128/IAI.01181-08
Cosson, P., Zulianello, L., Join-Lambert, O., Faurisson, F., Gebbie, L., Benghezal, M. et al. (2002) Pseudomonas aeruginosa virulence analyzed in a Dictyostelium discoideum host system. Journal of Bacteriology, 184(11), 3027-3033. Available from: https://doi.org/10.1128/JB.184.11.3027-3033.2002
Crabbé, A., Ledesma, M.A. & Nickerson, C.A. (2014) Mimicking the host and its microenvironment in vitro for studying mucosal infections by Pseudomonas aeruginosa. Pathogens and Disease, 71(1), 1-19. Available from: https://doi.org/10.1111/2049-632x.12180
Crabbé, A., Liu, Y., Matthijs, N., Rigole, P., De La Fuente-Nùñez, C., Davis, R. et al. (2017) Antimicrobial efficacy against pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum. Scientific Reports, 7, 43321. Available from: https://doi.org/10.1038/srep43321
Crone, S., Vives-Flórez, M., Kvich, L., Saunders, A.M., Malone, M., Nicolaisen, M.H. et al. (2020) The environmental occurrence of Pseudomonas aeruginosa. APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica, 128(3), 220-231. Available from: https://doi.org/10.1111/apm.13010
Cutuli, M.A., Petronio Petronio, G., Vergalito, F., Magnifico, I., Pietrangelo, L., Venditti, N. et al. (2019) Galleria mellonella as a consolidated in vivo model hosts: new developments in antibacterial strategies and novel drug testing. Virulence, 10(1), 527-541. Available from: https://doi.org/10.1080/21505594.2019.1621649
De Gregorio, E. (2002) The Toll and Imd pathways are the major regulators of the immune response in Drosophila. The EMBO Journal, 21(11), 2568-2579. Available from: https://doi.org/10.1093/emboj/21.11.2568
de Simone, M., Spagnuolo, L., Lorè, N.I., Rossi, G., Cigana, C., de Fino, I. et al. (2014) Host genetic background influences the response to the opportunistic Pseudomonas aeruginosa infection altering cell-mediated immunity and bacterial replication. PLoS One, 9(9), e106873. Available from: https://doi.org/10.1371/journal.pone.0106873
Denoux, C., Galletti, R., Mammarella, N., Gopalan, S., Werck, D., De Lorenzo, G. et al. (2008) Activation of defense response pathways by OGs and Flg22 elicitors in Arabidopsis seedlings. Molecular Plant, 1(3), 423-445. Available from: https://doi.org/10.1093/mp/ssn019
Diggle, S.P. & Whiteley, M. (2020) Microbe profile: Pseudomonas aeruginosa: opportunistic pathogen and lab rat. Microbiology (Reading, England), 166(1), 30-33. Available from: https://doi.org/10.1099/mic.0.000860
Djokic, L., Stankovic, N., Galic, I., Moric, I., Radakovic, N., Šegan, S. et al. (2022) Novel quorum quenching YtnP lactonase from Bacillus paralicheniformis reduces Pseudomonas aeruginosa virulence and increases antibiotic efficacy in vivo. Frontiers in Microbiology, 13, 906312. Available from: https://doi.org/10.3389/fmicb.2022.906312
Djonović, S., Urbach, J.M., Drenkard, E., Bush, J., Feinbaum, R., Ausubel, J.L. et al. (2013) Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants. PLoS Pathogens, 9(3), e1003217. Available from: https://doi.org/10.1371/journal.ppat.1003217
Dowling, R.B. & Wilson, R. (1999) Pseudomonas aeruginosa respiratory infections. Clinical Pulmonary Medicine, 6(5), 278-286.
Dwidar, M., Leung, B.M., Yaguchi, T., Takayama, S. & Mitchell, R.J. (2013) Patterning bacterial communities on epithelial cells. PLoS One, 8(6), e67165. Available from: https://doi.org/10.1371/journal.pone.0067165
Díaz-Pascual, F., Ortíz-Severín, J., Varas, M.A., Allende, M.L. & Chávez, F.P. (2017) In vivo host-pathogen interaction as revealed by global proteomic profiling of zebrafish larvae. Frontiers in Cellular and Infection Microbiology, 7, 334. Available from: https://doi.org/10.3389/fcimb.2017.00334
Eisenhardt, M., Schlupp, P., Höfer, F., Schmidts, T., Hoffmann, D., Czermak, P. et al. (2019) The therapeutic potential of the insect metalloproteinase inhibitor against infections caused by Pseudomonas aeruginosa. The Journal of Pharmacy and Pharmacology, 71(3), 316-328. Available from: https://doi.org/10.1111/jphp.13034
Elbehiry, A., Marzouk, E., Aldubaib, M., Moussa, I., Abalkhail, A., Ibrahem, M. et al. (2022) Pseudomonas species prevalence, protein analysis, and antibiotic resistance: an evolving public health challenge. AMB Express, 12(1), 53. Available from: https://doi.org/10.1186/s13568-022-01390-1
Elrod, R.P. & Braun, A.C. (1941) A phytopathogenic bacterium fatal to laboratory animals. Science, 94(2448), 520-521. Available from: https://doi.org/10.1126/science.94.2448.520
Ermolaeva, M.A. & Schumacher, B. (2014) Insights from the worm: the C. elegans model for innate immunity. Seminars in Immunology, 26(4), 303-309. Available from: https://doi.org/10.1016/j.smim.2014.04.005
Farghaly, R.M., Abdel-Aziz, N.M. & Mohammed, M.H. (2022) The occurrence and significance of Pseudomonas aeruginosa isolated from some meat products in Sohag city. SVU-International Journal of Veterinary Sciences, 5(4), 53-65. Available from: https://doi.org/10.21608/svu.2022.152457.1214
Faure, E., Kwong, K. & Nguyen, D. (2018) Pseudomonas aeruginosa in chronic lung infections: how to adapt within the host? Frontiers in Immunology, 9, 2416. Available from: https://doi.org/10.3389/fimmu.2018.02416
Feinbaum, R.L., Urbach, J.M., Liberati, N.T., Djonovic, S., Adonizio, A., Carvunis, A.-R. et al. (2012) Genome-wide identification of Pseudomonas aeruginosa virulence-related genes using a Caenorhabditis elegans infection model. PLoS Pathogens, 8(7), e1002813. Available from: https://doi.org/10.1371/journal.ppat.1002813
Felix, G., Duran, J.D., Volko, S. & Boller, T. (1999) Plants have a sensitive perception system for the most conserved domain of bacterial flagellin. The Plant Journal, 18(3), 265-276. Available from: https://doi.org/10.1046/j.1365-313x.1999.00265.x
Forti, F., Roach, D.R., Cafora, M., Pasini, M.E., Horner, D.S., Fiscarelli, E.V. et al. (2018) Design of a broad-range bacteriophage cocktail that reduces Pseudomonas aeruginosa biofilms and treats acute infections in two animal models. Antimicrobial Agents and Chemotherapy, 62(6), e02573-17. Available from: https://doi.org/10.1128/AAC.02573-17
Frith, W.J. (2010) Mixed biopolymer aqueous solutions-phase behaviour and rheology. Advances in Colloid and Interface Science, 161(1-2), 48-60. Available from: https://doi.org/10.1016/j.cis.2009.08.001
Grassi, L., Batoni, G., Ostyn, L., Rigole, P., Van den Bossche, S., Rinaldi, A.C. et al. (2019) The antimicrobial peptide Lin-SB056-1 and its dendrimeric derivative prevent pseudomonas aeruginosa biofilm formation in physiologically relevant models of chronic infections. Frontiers in Microbiology, 10, 198. Available from: https://doi.org/10.3389/fmicb.2019.00198
Gray, T.E., Guzman, K., Davis, C.W., Abdullah, L.H. & Nettesheim, P. (1996) Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells. American Journal of Respiratory Cell and Molecular Biology, 14(1), 104-112. Available from: https://doi.org/10.1165/ajrcmb.14.1.8534481
Green, S.K., Schroth, M.N., Cho, J.J., Kominos, S.K. & Vitanza-jack, V.B. (1974) Agricultural plants and soil as a reservoir for Pseudomonas aeruginosa. Applied Microbiology, 28(6), 987-991. Available from: https://doi.org/10.1128/am.28.6.987-991.1974
Growcott, E.J., Coulthard, A., Amison, R., Hardaker, E.L., Saxena, V., Malt, L. et al. (2011) Characterisation of a refined rat model of respiratory infection with Pseudomonas aeruginosa and the effect of ciprofloxacin. Journal of Cystic Fibrosis, 10(3), 166-174. Available from: https://doi.org/10.1016/j.jcf.2010.12.007
Hao, Y., Yang, W., Ren, J., Hall, Q., Zhang, Y. & Kaplan, J.M. (2018) Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide. eLife, 7, e36833. Available from: https://doi.org/10.7554/eLife.36833
Harrington, N.E., Littler, J.L. & Harrison, F. (2022) Transcriptome analysis of Pseudomonas aeruginosa biofilm infection in an ex vivo pig model of the cystic fibrosis lung. Applied and Environmental Microbiology, 88(3), e0178921. Available from: https://doi.org/10.1128/AEM.01789-21
He, J., Baldini, R.L., Déziel, E., Saucier, M., Zhang, Q., Liberati, N.T. et al. (2004) The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes. Proceedings of the National Academy of Sciences of the United States of America, 101(8), 2530-2535. Available from: https://doi.org/10.1073/pnas.0304622101
Hoffmann, J.A. (2003) The immune response of Drosophila. Nature, 426(6962), 33-38. Available from: https://doi.org/10.1038/nature02021
Hoffmann, N., Rasmussen, T.B., Jensen, P.Ø., Stub, C., Hentzer, M., Molin, S. et al. (2005) Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis. Infection and Immunity, 73(8), 5290. Available from: https://doi.org/10.1128/iai.73.8.5290.2005
Huang, A.J., Clarke, A.N., Jafari, N. & Leung, B.M. (2021) Characterization of patterned microbial growth dynamics in aqueous two-phase polymer scaffolds. ACS Biomaterials Science & Engineering, 7(12), 5506-5514. Available from: https://doi.org/10.1021/acsbiomaterials.1c01130
Huang, A.J., O'Brien, C.L., Dawe, N., Tahir, A., Scott, A.J. & Leung, B.M. (2022) Characterization of an engineered mucus microenvironment for in vitro modeling of host-microbe interactions. Scientific Reports, 12(1), 5515. Available from: https://doi.org/10.1038/s41598-022-09198-6
Høiby, N., Ciofu, O. & Bjarnsholt, T. (2010) Pseudomonas aeruginosa biofilms in cystic fibrosis. Future Microbiology, 5(11), 1663-1674. Available from: https://doi.org/10.2217/fmb.10.125
Idowu, T., Ammeter, D., Arthur, G., Zhanel, G.G. & Schweizer, F. (2019) Potentiation of β-lactam antibiotics and β-lactam/β-lactamase inhibitor combinations against MDR and XDR Pseudomonas aeruginosa using non-ribosomal tobramycin-cyclam conjugates. The Journal of Antimicrobial Chemotherapy, 74(9), 2640-2648. Available from: https://doi.org/10.1093/jac/dkz228
Issa, N., Guillaumot, N., Lauret, E., Matt, N., Schaeffer-Reiss, C., Van Dorsselaer, A. et al. (2018) The circulating protease persephone is an immune sensor for microbial proteolytic activities upstream of the Drosophila Toll pathway. Molecular Cell, 69(4), 539.e6-550.e6. Available from: https://doi.org/10.1016/j.molcel.2018.01.029
Jeon, J. & Yong, D. (2019) Two novel bacteriophages improve survival in Galleria mellonella infection and mouse acute pneumonia models infected with extensively drug-resistant Pseudomonas aeruginosa. Applied and Environmental Microbiology, 85(9), e02900-18. Available from: https://doi.org/10.1128/AEM.02900-18
Jin, T., Mohammad, M., Hu, Z., Fei, Y., Moore, E.R.B., Pullerits, R. et al. (2019) A novel mouse model for septic arthritis induced by Pseudomonas aeruginosa. Scientific Reports, 9(1), 16868. Available from: https://doi.org/10.1038/s41598-019-53434-5
Kahn, L. (2017) Perspective: the one-health way. Nature, 543, S47. Available from: https://doi.org/10.1038/543S47a
Kim, D.H., Feinbaum, R., Alloing, G., Emerson, F.E., Garsin, D.A., Inoue, H. et al. (2002) A conserved p38 map kinase pathway in Caenorhabditis elegans innate immunity. Science, 297(5581), 623-626. Available from: https://doi.org/10.1126/science.1073759
Kim, J., Hegde, M. & Jayaraman, A. (2010) Co-culture of epithelial cells and bacteria for investigating host-pathogen interactions. Lab on a Chip, 10(1), 43-50. Available from: https://doi.org/10.1039/b911367c
Kim, S.-H., Park, S.-Y., Heo, Y.-J. & Cho, Y.-H. (2008) Drosophila melanogaster-based screening for multihost virulence factors of Pseudomonas aeruginosa PA14 and identification of a virulence-attenuating factor HudA. Infection and Immunity, 76(9), 4152-4162. Available from: https://doi.org/10.1128/IAI.01637-07
Klockgether, J., Cramer, N., Wiehlmann, L., Davenport, C.F. & Tümmler, B. (2011) Pseudomonas aeruginosa genomic structure and diversity. Frontiers in Microbiology, 2, 150. Available from: https://doi.org/10.3389/fmicb.2011.00150
Koh, A.Y., Priebe, G.P. & Pier, G.B. (2005) Virulence of Pseudomonas aeruginosa in a murine model of gastrointestinal colonization and dissemination in neutropenia. Infection and Immunity, 73(4), 2262-2272. Available from: https://doi.org/10.1128/IAI.73.4.2262-2272.2005
Kominos, S.D., Copeland, C.E., Grosiak, B. & Postic, B. (1972) Introduction of Pseudomonas aeruginosa into a hospital via vegetables. Applied Microbiology, 24(4), 567-570. Available from: https://doi.org/10.1128/am.24.4.567-570.1972
Kropinski, A.M. & Chadwick, J.S. (1975) The pathogenicity of rough strains of Pseudomonas aeruginosa for galleria mellonella. Canadian Journal of Microbiology, 21(12), 2084-2088. Available from: https://doi.org/10.1139/m75-297
Kukavica-Ibrulj, I., Bragonzi, A., Paroni, M., Winstanley, C., Sanschagrin, F., O'Toole, G.A. et al. (2008) In vivo growth of Pseudomonas aeruginosa strains PAO1 and PA14 and the hypervirulent strain LESB58 in a rat model of chronic lung infection. Journal of Bacteriology, 190(8), 2804-2813. Available from: https://doi.org/10.1128/JB.01572-07
Laarman, A.J., Bardoel, B.W., Ruyken, M., Fernie, J., Milder, F.J., van Strijp, J.A.G. et al. (2012) Pseudomonas aeruginosa alkaline protease blocks complement activation via the classical and lectin pathways. The Journal of Immunology, 188(1), 386-393. Available from: https://doi.org/10.4049/jimmunol.1102162
Lai, C.-H., Chou, C.-Y., Ch'ang, L.-Y., Liu, C.-S. & Lin, W. (2000) Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Research, 10(5), 703-713. Available from: https://doi.org/10.1101/gr.10.5.703
Lansbury, L., Lim, B., Baskaran, V. & Lim, W.S. (2020) Co-infections in people with COVID-19: a systematic review and meta-analysis. The Journal of Infection, 81(2), 266-275. Available from: https://doi.org/10.1016/j.jinf.2020.05.046
Lau, G.W., Goumnerov, B.C., Walendziewicz, C.L., Hewitson, J., Xiao, W., Mahajan-Miklos, S. et al. (2003) The Drosophila melanogaster Toll pathway participates in resistance to infection by the gram-negative human pathogen Pseudomonas aeruginosa. Infection and Immunity, 71(7), 4059-4066. Available from: https://doi.org/10.1128/IAI.71.7.4059-4066.2003
Lauredo, I.T., Sabater, J.R., Ahmed, A., Botvinnikova, Y. & Abraham, W.M. (1998) Mechanism of pyocyanin- and 1-hydroxyphenazine-induced lung neutrophilia in sheep airways. Journal of Applied Physiology, 85(6), 2298-2304. Available from: https://doi.org/10.1152/jappl.1998.85.6.2298
Leung, C., Wadsworth, S.J., Yang, S.J. & Dorscheid, D.R. (2020) Structural and functional variations in human bronchial epithelial cells cultured in air-liquid interface using different growth media. American Journal of Physiology-Lung Cellular and Molecular Physiology, 318(5), L1063-L1073. Available from: https://doi.org/10.1152/ajplung.00190.2019
Lewis-Israeli, Y.R., Wasserman, A.H., Gabalski, M.A., Volmert, B.D., Ming, Y., Ball, K.A. et al. (2021) Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease. Nature Communications, 12(1), 5142. Available from: https://doi.org/10.1038/s41467-021-25329-5
Liehl, P., Blight, M., Vodovar, N., Boccard, F. & Lemaitre, B. (2006) Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model. PLoS Pathogens, 2(6), e56. Available from: https://doi.org/10.1371/journal.ppat.0020056
Lieschke, G.J., Oates, A.C., Crowhurst, M.O., Ward, A.C. & Layton, J.E. (2001) Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish. Blood, 98(10), 3087-3096. Available from: https://doi.org/10.1182/blood.v98.10.3087
Limmer, S., Haller, S., Drenkard, E., Lee, J., Yu, S., Kocks, C. et al. (2011) Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model. Proceedings of the National Academy of Sciences of the United States of America, 108(42), 17378-17383. Available from: https://doi.org/10.1073/pnas.1114907108
Lister, P.D., Wolter, D.J. & Hanson, N.D. (2009) Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clinical Microbiology Reviews, 22(4), 582-610. Available from: https://doi.org/10.1128/CMR.00040-09
Llamas, M.A. & van der Sar, A.M. (2014) Assessing Pseudomonas virulence with nonmammalian host: zebrafish. Methods in Molecular Biology (Clifton, N.J.), 1149, 709-721. Available from: https://doi.org/10.1007/978-1-4939-0473-0_55
Lyczak, J.B., Cannon, C.L. & Pier, G.B. (2000) Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microbes and Infection, 2, 1051-1060.
López-Bergami, P., Habelhah, H., Bhoumik, A., Zhang, W., Wang, L.H. & Ronai, Z. (2005) RACK1 mediates activation of JNK by protein kinase C [corrected]. Molecular Cell, 19(3), 309-320. Available from: https://doi.org/10.1016/j.molcel.2005.06.025
Mackenzie, J.S. & Jeggo, M. (2019) The one health approach-why is it so important? Tropical Medicine and Infectious Disease, 4(2), 88. Available from: https://doi.org/10.3390/tropicalmed4020088
Mahajan-Miklos, S., Tan, M.W., Rahme, L.G. & Ausubel, F.M. (1999) Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell, 96(1), 47-56. Available from: https://doi.org/10.1016/s0092-8674(00)80958-7
Marquart, M.E. (2011) Animal models of bacterial keratitis. Journal of Biomedicine & Biotechnology, 2011, 680642. Available from: https://doi.org/10.1155/2011/680642
Maslova, E., Shi, Y., Sjöberg, F., Azevedo, H.S., Wareham, D.W. & McCarthy, R.R. (2020) An invertebrate burn wound model that recapitulates the hallmarks of burn trauma and infection seen in mammalian models. Frontiers in Microbiology, 11, 998. Available from: https://doi.org/10.3389/fmicb.2020.00998
McCarron, A., Parsons, D. & Donnelley, M. (2021) Animal and cell culture models for cystic fibrosis: which model is right for your application? The American Journal of Pathology, 191(2), 228-242. Available from: https://doi.org/10.1016/j.ajpath.2020.10.017
Meisel, J.D., Panda, O., Mahanti, P., Schroeder, F.C. & Kim, D.H. (2014) Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell, 159(2), 267-280. Available from: https://doi.org/10.1016/j.cell.2014.09.011
Meister, M. & Lagueux, M. (2003) Drosophila blood cells. Cellular Microbiology, 5(9), 573-580. Available from: https://doi.org/10.1046/j.1462-5822.2003.00302.x
Mena, K.D. & Gerba, C.P. (2009) Risk assessment of Pseudomonas aeruginosa in water. Reviews of Environmental Contamination and Toxicology, 201, 71-115. Available from: https://doi.org/10.1007/978-1-4419-0032-6_3
Miller, A.J., Dye, B.R., Ferrer-Torres, D., Hill, D.R., Overeem, A.W., Shea, L.D. et al. (2019) Generation of lung organoids from human pluripotent stem cells in vitro. Nature Protocols, 14(2), 518-540. Available from: https://doi.org/10.1038/s41596-018-0104-8
Miyata, S., Casey, M., Frank, D.W., Ausubel, F.M. & Drenkard, E. (2003) Use of the Galleria mellonella caterpillar as a model host to study the role of the type III secretion system in Pseudomonas aeruginosa pathogenesis. Infection and Immunity, 71(5), 2404-2413. Available from: https://doi.org/10.1128/IAI.71.5.2404-2413.2003
Montefusco-Pereira, C.V., Horstmann, J.C., Ebensen, T., Beisswenger, C., Bals, R., Guzmán, C.A. et al. (2020) P. aeruginosa infected 3D co-culture of bronchial epithelial cells and macrophages at air-liquid interface for preclinical evaluation of anti-infectives. Journal of Visualized Experiments, 160, e61069. Available from: https://doi.org/10.3791/61069
Moura-Alves, P., Puyskens, A., Stinn, A., Klemm, M., Guhlich-Bornhof, U., Dorhoi, A. et al. (2019) Host monitoring of quorum sensing during Pseudomonas aeruginosa infection. Science, 366(6472), eaaw1629. Available from: https://doi.org/10.1126/science.aaw1629
Mukherjee, K., Altincicek, B., Hain, T., Domann, E., Vilcinskas, A. & Chakraborty, T. (2010) Galleria mellonella as a model system for studying Listeria pathogenesis. Applied and Environmental Microbiology, 76(1), 310-317. Available from: https://doi.org/10.1128/AEM.01301-09
Murphy, T.F. (2009) Pseudomonas aeruginosa in adults with chronic obstructive pulmonary disease. Current Opinion in Pulmonary Medicine, 15(2), 138-142. Available from: https://doi.org/10.1097/MCP.0b013e328321861a
Myers, A.L., Harris, C.M., Choe, K.-M. & Brennan, C.A. (2018) Inflammatory production of reactive oxygen species by Drosophila hemocytes activates cellular immune defenses. Biochemical and Biophysical Research Communications, 505(3), 726-732. Available from: https://doi.org/10.1016/j.bbrc.2018.09.126
Ménard, G., Rouillon, A., Cattoir, V. & Donnio, P.Y. (2021) Galleria mellonella as a suitable model of bacterial infection: past, present and future. Frontiers in Cellular and Infection Microbiology, 11, 782733. Available from: https://doi.org/10.3389/fcimb.2021.782733
Müller, L., Brighton, L.E., Carson, J.L., Fischer, W.A. & Jaspers, I. (2013) Culturing of human nasal epithelial cells at the air liquid interface. Journal of Visualized Experiments, 80, 50646. Available from: https://doi.org/10.3791/50646
Müller, L., Murgia, X., Siebenbürger, L., Börger, C., Schwarzkopf, K., Sewald, K. et al. (2018) Human airway mucus alters susceptibility of pseudomonas aeruginosa biofilms to tobramycin, but not colistin. Journal of Antimicrobial Chemotherapy, 73(10), 2762-2769. Available from: https://doi.org/10.1093/jac/dky241
Narten, M., Rosin, N., Schobert, M. & Tielen, P. (2012) Susceptibility of Pseudomonas aeruginosa urinary tract isolates and influence of urinary tract conditions on antibiotic tolerance. Current Microbiology, 64(1), 7-16. Available from: https://doi.org/10.1007/s00284-011-0026-y
Navis, A., Marjoram, L. & Bagnat, M. (2013) Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish. Development, 140(8), 1703-1712. Available from: https://doi.org/10.1242/dev.091819
Nishi, T. & Tsuchiya, K. (1978) Experimental urinary tract infection with Pseudomonas aeruginosa in mice. Infection and Immunity, 22(2), 508-515. Available from: 10.1128/iai.22.2.508-515.1978
Nogaret, P., El Garah, F. & Blanc-Potard, A.B. (2021) A novel infection protocol in zebrafish embryo to assess Pseudomonas aeruginosa virulence and validate efficacy of a quorum sensing inhibitor in vivo. Pathogens, 10(4), 401. Available from: https://doi.org/10.3390/pathogens10040401
Ortiz-Muñoz, G. & Looney, M.R. (2015) Non-invasive intratracheal instillation in mice. Bio-Protocol, 5(12), e1504. Available from: https://doi.org/10.21769/bioprotoc.1504
Palmer, K.L., Aye, L.M. & Whiteley, M. (2007) Nutritional cues control Pseudomonas aeruginosa multicellular behaviour in cystic fibrosis sputum. Journal of Bacteriology, 189(22), 8079-8087. Available from: https://doi.org/10.1128/JB.01138-07
Pan, X. & Wu, W. (2020) Murine acute pneumonia model of Pseudomonas aeruginosa lung infection. Bio-Protocol, 10(21), e3805. Available from: https://doi.org/10.21769/bioprotoc.3805
Pandey, U.B. & Nichols, C.D. (2011) Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacological Reviews, 63(2), 411-436. Available from: https://doi.org/10.1124/pr.110.003293
Park, H.R., Hong, M.K., Hwang, S.Y., Park, Y.K., Kwon, K.H., Yoon, J.W. et al. (2014) Characterisation of Pseudomonas aeruginosa related to bovine mastitis. Acta Veterinaria Hungarica, 62(1), 1-12. Available from: https://doi.org/10.1556/AVet.2013.054
Pedersen, S.S., Shand, G.H., Hansen, B.L. & Hansen, G.N. (1990) Induction of experimental chronic Pseudomonas aeruginosa lung infection with P. aeruginosa entrapped in alginate microspheres. APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica, 98(3), 203-211.
Phennicie, R.T., Sullivan, M.J., Singer, J.T., Yoder, J.A. & Kim, C.H. (2010) Specific resistance to Pseudomonas aeruginosa infection in zebrafish is mediated by the cystic fibrosis transmembrane conductance regulator. Infection and Immunity, 78(11), 4542-4550. Available from: https://doi.org/10.1128/IAI.00302-10
Pinnock, A., Shivshetty, N., Roy, S., Rimmer, S., Douglas, I., MacNeil, S. et al. (2017) Ex vivo rabbit and human corneas as models for bacterial and fungal keratitis. Graefe's Archive for Clinical and Experimental Ophthalmology, 255(2), 333-342. Available from: https://doi.org/10.1007/s00417-016-3546-0
Pletzer, D., Mansour, S.C., Wuerth, K., Rahanjam, N. & Hancock, R.E.W. (2017) New mouse model for chronic infections by Gram-negative bacteria enabling the study of anti-infective efficacy and host-microbe interactions. mBio, 8(1), e00140-17. Available from: https://doi.org/10.1128/mBio.00140-17
Pletzer, D., Wolfmeier, H., Bains, M. & Hancock, R.E.W. (2017) Synthetic peptides to target stringent response-controlled virulence in a Pseudomonas aeruginosa murine cutaneous infection model. Frontiers in Microbiology, 8, 1867. Available from: https://doi.org/10.3389/fmicb.2017.01867
Plotnikova, J.M., Rahme, L.G. & Ausubel, F.M. (2000) Pathogenesis of the human opportunistic pathogen Pseudomonas aeruginosa PA14 in Arabidopsis. Plant Physiology, 124(4), 1766-1774. Available from: https://doi.org/10.1104/pp.124.4.1766
Pont, S. & Blanc-Potard, A.B. (2021) Zebrafish embryo infection model to investigate Pseudomonas aeruginosa interaction with innate immunity and validate new therapeutics. Frontiers in Cellular and Infection Microbiology, 11, 745851. Available from: https://doi.org/10.3389/fcimb.2021.745851
Pukkila-Worley, R. & Ausubel, F.M. (2012) Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium. Current Opinion in Immunology, 24(1), 3-9. Available from: https://doi.org/10.1016/j.coi.2011.10.004
Rabin, S.D. & Hauser, A.R. (2003) Pseudomonas aeruginosa ExoU, a toxin transported by the type III secretion system, kills Saccharomyces cerevisiae. Infection and Immunity, 71(7), 4144-4150. Available from: https://doi.org/10.1128/IAI.71.7.4144-4150.2003
Rahme, L.G., Stevens, E.J., Wolfort, S.F., Shao, J., Tompkins, R.G. & Ausubel, F.M. (1995) Common virulence factors for bacterial pathogenicity in plants and animals. Science, 268(5219), 1899-1902. Available from: https://doi.org/10.1126/science.7604262
Rahme, L.G., Tan, M.W., Le, L., Wong, S.M., Tompkins, R.G., Calderwood, S.B. et al. (1997) Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors. Proceedings of the National Academy of Sciences of the United States of America, 94(24), 13245-13250. Available from: https://doi.org/10.1073/pnas.94.24.13245
Raz, A., Serrano, A., Hernandez, A., Euler, C.W. & Fischetti, V.A. (2019) Isolation of phage lysins that effectively kill Pseudomonas aeruginosa in mouse models of lung and skin infection. Antimicrobial Agents and Chemotherapy, 63(7), e00024. Available from: https://doi.org/10.1128/aac.00024-19
Reddy, K.C., Andersen, E.C., Kruglyak, L. & Kim, D.H. (2009) A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Science (New York, N.Y.), 323(5912), 382-384. Available from: https://doi.org/10.1126/science.1166527
Revelli, D.A., Boylan, J.A. & Gherardini, F.C. (2012) A non-invasive intratracheal inoculation method for the study of pulmonary melioidosis. Frontiers in Cellular and Infection Microbiology, 2, 164. Available from: https://doi.org/10.3389/fcimb.2012.00164
Ringen, L.M. & Drake, C.H. (1952) A study of the incidence of Pseudomonas aeruginosa from various natural sources. Journal of Bacteriology, 64(6), 841-845. Available from: https://doi.org/10.1128/jb.64.6.841-845.1952
Rocker, A.J., Weiss, A.R., Lam, J.S., Van Raay, T.J. & Khursigara, C.M. (2015) Visualizing and quantifying Pseudomonas aeruginosa infection in the hindbrain ventricle of zebrafish using confocal laser scanning microscopy. Journal of Microbiological Methods, 117, 85-94. Available from: https://doi.org/10.1016/j.mimet.2015.07.013
Rodríguez-Sevilla, G., Rigauts, C., Vandeplassche, E., Ostyn, L., Mahíllo-Fernández, I., Esteban, J. et al. (2018) Influence of three-dimensional lung epithelial cells and interspecies interactions on antibiotic efficacy against Mycobacterium abscessus and Pseudomonas aeruginosa. Pathogens and Disease, 76(4), fty034. Available from: https://doi.org/10.1093/femspd/fty034
Rosen, B.H., Evans, T.I.A., Moll, S.R., Gray, J.S., Liang, B., Sun, X. et al. (2018) Infection is not required for mucoinflammatory lung disease in CFTR-knockout ferrets. American Journal of Respiratory and Critical Care Medicine, 197(10), 1308-1318. Available from: https://doi.org/10.1164/rccm.201708-1616OC
Rosowski, E.E. (2020) Illuminating macrophage contributions to host-pathogen interactions in vivo: the power of zebrafish. Infection and Immunity, 88(7), e00906-19. Available from: https://doi.org/10.1128/IAI.00906-19
Rubio-Gómez, J.M., Santiago, C.M., Udaondo, Z., Garitaonaindia, M.T., Krell, T., Ramos, J.L. et al. (2020) Full transcriptomic response of Pseudomonas aeruginosa to an inulin-derived fructooligosaccharide. Frontiers in Microbiology, 11, 202. Available from: https://doi.org/10.3389/fmicb.2020.00202
Sadikot, R.T., Blackwell, T.S., Christman, J.W. & Prince, A.S. (2005) Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. American Journal of Respiratory and Critical Care Medicine, 171(11), 1209-1223. Available from: https://doi.org/10.1164/rccm.200408-1044SO
Salminen, T.S. & Rämet, M. (2016) Pickle flavors relish in Drosophila immunity. Cell Host & Microbe, 20(3), 273-274. Available from: https://doi.org/10.1016/j.chom.2016.08.008
Sawa, T. (2014) The molecular mechanism of acute lung injury caused by Pseudomonas aeruginosa: from bacterial pathogenesis to host response. Journal of Intensive Care, 2(1), 10. Available from: https://doi.org/10.1186/2052-0492-2-10
Schellenberger, R., Crouzet, J., Nickzad, A., Shu, L.J., Kutschera, A., Gerster, T. et al. (2021) Bacterial rhamnolipids and their 3-hydroxyalkanoate precursors activate Arabidopsis innate immunity through two independent mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 118(39), e2101366118. Available from: https://doi.org/10.1073/pnas.2101366118
Schick, A. & Kassen, R. (2018) Rapid diversification of Pseudomonas aeruginosa in cystic fibrosis lung-like conditions. Proceedings of the National Academy of Sciences of the United States of America, 115(42), 10714-10719. Available from: 10.1073/pnas.1721270115
Sheehan, G., Garvey, A., Croke, M. & Kavanagh, K. (2018) Innate humoral immune defences in mammals and insects: the same, with differences? Virulence, 9(1), 1625-1639. Available from: https://doi.org/10.1080/21505594.2018.1526531
Shigemura, K., Arakawa, S., Sakai, Y., Kinoshita, S., Tanaka, K. & Fujisawa, M. (2006) Complicated urinary tract infection caused by Pseudomonas aeruginosa in a single institution (1999-2003). International Journal of Urology, 13(5), 538-542. Available from: https://doi.org/10.1111/j.1442-2042.2006.01359.x
Singh, J. & Aballay, A. (2019) Intestinal infection regulates behavior and learning via neuroendocrine signaling. eLife, 8, e50033. Available from: https://doi.org/10.7554/eLife.50033
Siriyong, T., Voravuthikunchai, S.P. & Coote, P.J. (2018) Steroidal alkaloids and conessine from the medicinal plant Holarrhena antidysenterica restore antibiotic efficacy in a galleria mellonella model of multidrug-resistant Pseudomonas aeruginosa infection. BMC Complementary and Alternative Medicine, 18(1), 285. Available from: https://doi.org/10.1186/s12906-018-2348-9
Southam, D.S., Dolovich, M. & O'byrne, P.M. (2002) Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia. American Journal of Physiology-Lung Cellular and Molecular Physiology, 282, 833-839. Available from: https://doi.org/10.1152/ajplung.00173.2001
Spagnuolo, L., de Simone, M., Lorè, N.I., de Fino, I., Basso, V., Mondino, A. et al. (2016) The host genetic background defines diverse immune-reactivity and susceptibility to chronic Pseudomonas aeruginosa respiratory infection. Scientific Reports, 6, 36924. Available from: https://doi.org/10.1038/srep36924
Stoltz, D.A., Ozer, E.A., Taft, P.J., Barry, M., Liu, L., Kiss, P.J. et al. (2008) Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1. Journal of Clinical Investigation, 118(9), 3123-3131. Available from: https://doi.org/10.1172/JCI35147
Styer, K.L., Singh, V., Macosko, E., Steele, S.E., Bargmann, C.I. & Aballay, A. (2008) Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR. Science (New York, N.Y.), 322(5900), 460-464. Available from: https://doi.org/10.1126/science.1163673
Tacconelli, E., Carrara, E., Savoldi, A., Harbarth, S., Mendelson, M., Monnet, D.L. et al. (2018) Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. The Lancet. Infectious Diseases, 18(3), 318-327. Available from: https://doi.org/10.1016/S1473-3099(17)30753-3
Tan, K.S., Gamage, A.M. & Liu, J. (2022) Human nasal epithelial cells (hnecs) generated by air-liquid interface (ALI) culture as a model system for studying the pathogenesis of SARS-COV-2. Methods in Molecular Biology, 2452, 213-224. Available from: https://doi.org/10.1007/978-1-0716-2111-0_14
Tan, M.-W., Mahajan-Miklos, S. & Ausubel, F.M. (1999) Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis. Proceedings of the National Academy of Sciences of the United States of America, 96(2), 715-720. Available from: https://doi.org/10.1073/pnas.96.2.715
Tan, M.-W., Rahme, L.G., Sternberg, J.A., Tompkins, R.G. & Ausubel, F.M. (1999) Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors. Proceedings of the National Academy of Sciences of the United States of America, 96(5), 2408-2413. Available from: https://doi.org/10.1073/pnas.96.5.2408
Tang, M., Liao, S., Qu, J., Liu, Y., Han, S., Cai, Z. et al. (2022) Evaluating bacterial pathogenesis using a model of human airway organoids infected with Pseudomonas aeruginosa biofilms. Microbiology Spectrum, 10, e0240822. Available from: https://doi.org/10.1128/spectrum.02408-22
Thomas, P. & Sekhar, A.C. (2016) Effects due to Rhizospheric soil application of an antagonistic bacterial endophyte on native bacterial community and its survival in soil: a case study with Pseudomonas aeruginosa from banana. Frontiers in Microbiology, 7, 493. Available from: https://doi.org/10.3389/fmicb.2016.00493
Thomaz, L., Gustavo de Almeida, L., Silva, F.R.O., Cortez, M., Taborda, C.P. & Spira, B. (2020) In vivo activity of silver nanoparticles against Pseudomonas aeruginosa infection in Galleria mellonella. Frontiers in Microbiology, 11, 582107. Available from: https://doi.org/10.3389/fmicb.2020.582107
Tojo, S., Naganuma, F., Arakawa, K. & Yokoo, S. (2000) Involvement of both granular cells and plasmatocytes in phagocytic reactions in the greater wax moth, galleria mellonella. Journal of Insect Physiology, 46(7), 1129-1135. Available from: https://doi.org/10.1016/s0022-1910(99)00223-1
Torraca, V., Masud, S., Spaink, H.P. & Meijer, A.H. (2014) Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model. Disease Models and Mechanisms, 7(7), 785-797. Available from: https://doi.org/10.1242/dmm.015594
Trede, N.S., Langenau, D.M., Traver, D., Look, A.T. & Zon, L.I. (2004) The use of zebrafish to understand immunity. Immunity, 20(4), 367-379. Available from: https://doi.org/10.1016/s1074-7613(04)00084-6
Tsai, C.J., Loh, J.M. & Proft, T. (2016) Galleria mellonella infection models for the study of bacterial diseases and for antimicrobial drug testing. Virulence, 7(3), 214-229. Available from: https://doi.org/10.1080/21505594.2015.1135289
Ubani-Ukoma, U., Gibson, D., Schultz, G., Silva, B.O. & Chauhan, A. (2019) Evaluating the potential of drug eluting contact lenses for treatment of bacterial keratitis using an ex vivo corneal model. International Journal of Pharmaceutics, 565, 499-508. Available from: https://doi.org/10.1016/j.ijpharm.2019.05.031
Urbach, J.M. & Ausubel, F.M. (2017) The NBS-LRR architectures of plant R-proteins and metazoan NLRs evolved in independent events. Proceedings of the National Academy of Sciences of the United States of America, 114(5), 1063-1068. Available from: https://doi.org/10.1073/pnas.1619730114
Vandelpassche, E., Sass, A., Lemarcq, A., Dandekar, A.A., Coenye, T. & Crabbe, A. (2019) In vitro evolution of Pseudomonas aeruginosa biofilms in the presence of cystic fibrosis lung microbiome members. Scientific Reports, 9, 12859. Available from: https://doi.org/10.1038/s41598-019-49371-y
Vasquez-Rifo, A., Cook, J., McEwan, D.L., Shikara, D., Ausubel, F.M., Di Cara, F. et al. (2022) ABCDs of the relative contributions of Pseudomonas aeruginosa quorum sensing systems to virulence in diverse nonvertebrate hosts. MBio, 13(2), e0041722. Available from: https://doi.org/10.1128/mbio.00417-22
Vertyporokh, L. & Wojda, I. (2020) Immune response of galleria mellonella after injection with non-lethal and lethal dosages of Candida albicans. Journal of Invertebrate Pathology, 170, 107327. Available from: https://doi.org/10.1016/j.jip.2020.107327
von Klitzing, E., Ekmekciu, I., Bereswill, S. & Heimesaat, M.M. (2017) Intestinal and systemic immune responses upon multi-drug resistant Pseudomonas aeruginosa colonization of mice harboring a human gut microbiota. Frontiers in Microbiology, 8, 2590. Available from: https://doi.org/10.3389/fmicb.2017.02590
Walker, T.S., Bais, H.P., Déziel, E., Schweizer, H.P., Rahme, L.G., Fall, R. et al. (2004) Pseudomonas aeruginosa-plant root interactions. Pathogenicity, biofilm formation, and root exudation. Plant Physiology, 134(1), 320-331. Available from: https://doi.org/10.1104/pp.103.027888
Wedde, M., Weise, C., Kopacek, P., Franke, P. & Vilcinskas, A. (1998) Purification and characterization of an inducible metalloprotease inhibitor from the hemolymph of greater wax moth larvae. Galleria Mellonella. European Journal of Biochemistry, 255(3), 535-543. Available from: https://doi.org/10.1046/j.1432-1327.1998.2550535.x
Wiesmann, C.L., Zhang, Y., Alford, M., Hamilton, C.D., Dosanjh, M., Thoms, D. et al. (2023) The ColR/S two-component system is a conserved determinant of host association across Pseudomonas species. The ISME Journal, 17(2), 286-296. Available from: https://doi.org/10.1038/s41396-022-01343-3
Wu, B.C., Haney, E.F., Akhoundsadegh, N., Pletzer, D., Trimble, M.J., Adriaans, A.E. et al. (2021) Human organoid biofilm model for assessing antibiofilm activity of novel agents. Npj Biofilms and Microbiomes, 7(1), 8. Available from: https://doi.org/10.1038/s41522-020-00182-4
Yaguchi, T., Lee, S., Choi, W.S., Kim, D., Kim, T., Mitchell, R.J. et al. (2010) Micropatterning bacterial suspensions using aqueous two phase systems. The Analyst, 135(11), 2848-2852. Available from: https://doi.org/10.1039/c0an00464b
Yonker, L.M., Mou, H., Chu, K.K., Pazos, M.A., Leung, H., Cui, D. et al. (2017) Development of a primary human co-culture model of inflamed airway mucosa. Scientific Reports, 7(1), 8182. Available from: https://doi.org/10.1038/s41598-017-08567-w
Yorgey, P., Rahme, L.G., Tan, M.W. & Ausubel, F.M. (2001) The roles of mucD and alginate in the virulence of Pseudomonas aeruginosa in plants, nematodes and mice. Molecular Microbiology, 41(5), 1063-1076. Available from: https://doi.org/10.1046/j.1365-2958.2001.02580.x
Zanin, M., Baviskar, P., Webster, R. & Webby, R. (2016) The interaction between respiratory pathogens and mucus. Cell Host & Microbe, 19(2), 159-168. Available from: https://doi.org/10.1016/j.chom.2016.01.001
Zeng, Z., Huang, B., Parvez, R.K., Li, Y., Chen, J., Vonk, A.C. et al. (2021) Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors. Nature. Communications, 12(1), 3641. Available from: https://doi.org/10.1038/s41467-021-23911-5
Zhang, Z. & Chen, J. (2016) Atomic structure of the cystic fibrosis transmembrane conductance regulator. Cell, 167(6), 1586.e9-1597.e9. Available from: https://doi.org/10.1016/j.cell.2016.11.014
Zhang, Z., Yao, B. & Huang, R. (2022) First report of Pseudomonas aeruginosa causing basal stem rot of Solanum lycopersicum in China. Plant Disease, 106(5), 1515. Available from: https://doi.org/10.1094/PDIS-08-21-1830-PDN
Zheng, Z., Tharmalingam, N., Liu, Q., Jayamani, E., Kim, W., Fuchs, B.B. et al. (2017) Synergistic efficacy of Aedes aegypti antimicrobial peptide cecropin A2 and tetracycline against Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 61(7), e00686-17. Available from: https://doi.org/10.1128/AAC.00686-17
Zipfel, C., Robatzek, S., Navarro, L., Oakeley, E.J., Jones, J.D., Felix, G. et al. (2004) Bacterial disease resistance in Arabidopsis through flagellin perception. Nature, 428(6984), 764-767. Available from: https://doi.org/10.1038/nature02485
Zrieq, R., Sana, T.G., Vergin, S., Garvis, S., Volfson, I., Bleves, S. et al. (2015) Genome-wide screen of Pseudomonas aeruginosa in Saccharomyces cerevisiae identifies new virulence factors. Frontiers in Cellular and Infection Microbiology, 5, 81. Available from: https://doi.org/10.3389/fcimb.2015.00081