Voxel-Based Dosimetry Predicts Hepatotoxicity in Hepatocellular Carcinoma Patients Undergoing Radioembolization with

Humans Carcinoma, Hepatocellular / diagnostic imaging Liver Neoplasms / diagnostic imaging Microspheres Retrospective Studies Embolization, Therapeutic / adverse effects Tomography, Emission-Computed, Single-Photon Chemical and Drug Induced Liver Injury Yttrium Radioisotopes / adverse effects
SIRT liver toxicity multicompartment dosimetry radioembolization voxel-based dosimetry

Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
07 2023
Historique:
received: 05 10 2022
revised: 07 03 2023
medline: 5 7 2023
pubmed: 9 6 2023
entrez: 8 6 2023
Statut: ppublish

Résumé

Personalized dosimetry holds promise to improve radioembolization treatment outcomes in hepatocellular carcinoma (HCC) patients. To this end, tolerance absorbed doses for nontumor liver tissue are assessed by calculating the mean absorbed dose to the whole nontumor liver tissue (AD-WNTLT), which may be limited by its neglect of nonuniform dose distribution. Thus, we analyzed whether voxel-based dosimetry could be more accurate in predicting hepatotoxicity in HCC patients undergoing radioembolization.

Identifiants

DOI: 10.2967/jnumed.122.264996 PMID: 37290792
pubmed: 37290792
pii: jnumed.122.264996
doi: 10.2967/jnumed.122.264996
doi:

Substances chimiques

Yttrium Radioisotopes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1102-1108

Informations de copyright

© 2023 by the Society of Nuclear Medicine and Molecular Imaging.

Auteurs

Masao Watanabe (M)

Department of Nuclear Medicine, University Clinic Essen, Essen, Germany.
University of Duisburg-Essen and German Cancer Consortium-University Hospital, Essen, Germany.

Hong Grafe (H)

Department of Nuclear Medicine, University Clinic Essen, Essen, Germany.
University of Duisburg-Essen and German Cancer Consortium-University Hospital, Essen, Germany.

Jens Theysohn (J)

University of Duisburg-Essen and German Cancer Consortium-University Hospital, Essen, Germany.
Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Clinic Essen, Essen, Germany.

Benedikt Schaarschmidt (B)

University of Duisburg-Essen and German Cancer Consortium-University Hospital, Essen, Germany.
Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Clinic Essen, Essen, Germany.

Johannes Ludwig (J)

University of Duisburg-Essen and German Cancer Consortium-University Hospital, Essen, Germany.
Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Clinic Essen, Essen, Germany.

Leonie Jochheim (L)

University of Duisburg-Essen and German Cancer Consortium-University Hospital, Essen, Germany.
Department of Gastroenterology and Hepatology, University Clinic Essen, Essen, Germany; and.

Matthias Jeschke (M)

University of Duisburg-Essen and German Cancer Consortium-University Hospital, Essen, Germany.
Department of Gastroenterology and Hepatology, University Clinic Essen, Essen, Germany; and.

Hartmut Schmidt (H)

University of Duisburg-Essen and German Cancer Consortium-University Hospital, Essen, Germany.
Department of Gastroenterology and Hepatology, University Clinic Essen, Essen, Germany; and.

Wolfgang P Fendler (WP)

Department of Nuclear Medicine, University Clinic Essen, Essen, Germany.
University of Duisburg-Essen and German Cancer Consortium-University Hospital, Essen, Germany.

Alexandros Moraitis (A)

Department of Nuclear Medicine, University Clinic Essen, Essen, Germany.
University of Duisburg-Essen and German Cancer Consortium-University Hospital, Essen, Germany.

Ken Herrmann (K)

Department of Nuclear Medicine, University Clinic Essen, Essen, Germany.
University of Duisburg-Essen and German Cancer Consortium-University Hospital, Essen, Germany.

Kelsey L Pomykala (KL)

Institute for AI in Medicine, University Medicine Essen, Essen, Germany.

Manuel Weber (M)

Department of Nuclear Medicine, University Clinic Essen, Essen, Germany; manuel.weber@uk-essen.de.
University of Duisburg-Essen and German Cancer Consortium-University Hospital, Essen, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Voxel-Based Dosimetry Predicts Hepatotoxicity...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › Voxel-Based Dosimetry Predicts Hepatotoxicity...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Voxel-Based Dosimetry Predicts Hepatotoxicity...
questionsmedicales.fr › Équipement et fournitures › Microsphères › Voxel-Based Dosimetry Predicts Hepatotoxicity...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Voxel-Based Dosimetry Predicts Hepatotoxicity...
questionsmedicales.fr › Thérapeutique › Occlusion thérapeutique › Embolisation thérapeutique › Voxel-Based Dosimetry Predicts Hepatotoxicity...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission monophotonique › Voxel-Based Dosimetry Predicts Hepatotoxicity...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Voxel-Based Dosimetry Predicts Hepatotoxicity...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Terres rares › Yttrium › Isotopes de l'yttrium › Radio-isotopes de l'yttrium › Voxel-Based Dosimetry Predicts Hepatotoxicity...