Aging and chronic inflammation: highlights from a multidisciplinary workshop.
Aging
Biomodulina T
Cell senescence
Chronic inflammation
Immunosenescence
Inflammaging
Metformin
SASP
Senolytic
Journal
Immunity & ageing : I & A
ISSN: 1742-4933
Titre abrégé: Immun Ageing
Pays: England
ID NLM: 101235427
Informations de publication
Date de publication:
08 Jun 2023
08 Jun 2023
Historique:
received:
07
02
2023
accepted:
06
06
2023
medline:
9
6
2023
pubmed:
9
6
2023
entrez:
8
6
2023
Statut:
epublish
Résumé
Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. Aging entails changes in the immune system characterized by a decrease in thymic output of naïve lymphocytes, an accumulated chronic antigenic stress notably caused by chronic infections such as cytomegalovirus (CMV), and immune cell senescence with acquisition of an inflammatory senescence-associated secretory phenotype (SASP). For this reason, and due to the SASP originating from other tissues, aging is commonly accompanied by low-grade chronic inflammation, termed "inflammaging". After decades of accumulating evidence regarding age-related processes and chronic inflammation, the domain now appears mature enough to allow an integrative reinterpretation of old data. Here, we provide an overview of the topics discussed in a recent workshop "Aging and Chronic Inflammation" to which many of the major players in the field contributed. We highlight advances in systematic measurement and interpretation of biological markers of aging, as well as their implications for human health and longevity and the interventions that can be envisaged to maintain or improve immune function in older people.
Identifiants
pubmed: 37291596
doi: 10.1186/s12979-023-00352-w
pii: 10.1186/s12979-023-00352-w
pmc: PMC10248980
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
25Informations de copyright
© 2023. The Author(s).
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