Multi-omic Profiling Reveals Early Immunological Indicators for Identifying COVID-19 Progressors.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
26 May 2023
26 May 2023
Historique:
pubmed:
9
6
2023
medline:
9
6
2023
entrez:
9
6
2023
Statut:
epublish
Résumé
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a rapid response by the scientific community to further understand and combat its associated pathologic etiology. A focal point has been on the immune responses mounted during the acute and post-acute phases of infection, but the immediate post-diagnosis phase remains relatively understudied. We sought to better understand the immediate post-diagnosis phase by collecting blood from study participants soon after a positive test and identifying molecular associations with longitudinal disease outcomes. Multi-omic analyses identified differences in immune cell composition, cytokine levels, and cell subset-specific transcriptomic and epigenomic signatures between individuals on a more serious disease trajectory (Progressors) as compared to those on a milder course (Non-progressors). Higher levels of multiple cytokines were observed in Progressors, with IL-6 showing the largest difference. Blood monocyte cell subsets were also skewed, showing a comparative decrease in non-classical CD14
Identifiants
pubmed: 37292797
doi: 10.1101/2023.05.25.542297
pmc: PMC10246026
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : OT2 HL158287
Pays : United States
Organisme : NHLBI NIH HHS
ID : UH3 HL140144
Pays : United States
Organisme : NHLBI NIH HHS
ID : R25 HL126140
Pays : United States
Organisme : NIH HHS
ID : C06 OD028307
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD109777
Pays : United States
Organisme : NHLBI NIH HHS
ID : OT2 HL161847
Pays : United States
Organisme : NHLBI NIH HHS
ID : UG3 HL140144
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL138377
Pays : United States
Organisme : NHLBI NIH HHS
ID : R33 HL151254
Pays : United States
Investigateurs
Chen Chen
(C)
Sairam Parthasarathy
(S)
Victor F Tapson
(VF)
James N Moy
(JN)
Christopher R deFilippi
(CR)
Ivan O Rosas
(IO)
Mujeeb Basit
(M)
Mirella Salvatore
(M)
Jerry A Krishnan
(JA)
Commentaires et corrections
Type : UpdateIn
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