Evaluating Approaches for Constructing Polygenic Risk Scores for Prostate Cancer in Men of African and European Ancestry.

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
15 May 2023
Historique:
medline: 9 6 2023
pubmed: 9 6 2023
entrez: 9 6 2023
Statut: epublish

Résumé

Genome-wide polygenic risk scores (GW-PRS) have been reported to have better predictive ability than PRS based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several GW-PRS approaches to a recently developed PRS of 269 established prostate cancer risk variants from multi-ancestry GWAS and fine-mapping studies (PRS

Identifiants

DOI: 10.1101/2023.05.12.23289860 PMID: 37292833 PMC: PMC10246022
pubmed: 37292833
doi: 10.1101/2023.05.12.23289860
pmc: PMC10246022
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : R01 CA165862
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA214253
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148537
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA246063
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA257328
Pays : United States

Commentaires et corrections

Type : UpdateIn

Références

JAMA. 2016 Jan 5;315(1):68-76
pubmed: 26746459
Am J Hum Genet. 2020 May 7;106(5):707-716
pubmed: 32386537
Am J Hum Genet. 2022 Jan 6;109(1):12-23
pubmed: 34995502
Bioinformatics. 2021 Apr 1;36(22-23):5424-5431
pubmed: 33326037
Nat Genet. 2021 Jan;53(1):65-75
pubmed: 33398198
Prostate. 2020 Jan;80(1):83-87
pubmed: 31634418
Am J Epidemiol. 2000 Feb 15;151(4):346-57
pubmed: 10695593
Nature. 2009 Aug 6;460(7256):748-52
pubmed: 19571811
PLoS Comput Biol. 2020 Feb 11;16(2):e1007565
pubmed: 32045423
J Natl Cancer Inst. 2022 May 9;114(5):771-774
pubmed: 33792693
Nature. 2010 Sep 2;467(7311):52-8
pubmed: 20811451
Nat Commun. 2020 Jul 3;11(1):3353
pubmed: 32620889
Am J Hum Genet. 2020 Sep 3;107(3):432-444
pubmed: 32758450
Nat Genet. 2018 Sep;50(9):1219-1224
pubmed: 30104762
J Clin Epidemiol. 2016 Feb;70:214-23
pubmed: 26441289
J Natl Cancer Inst. 2015 Oct 12;107(12):djv279
pubmed: 26464424

Auteurs

Burcu F Darst (BF)

Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Jiayi Shen (J)

Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Ravi K Madduri (RK)

Argonne National Laboratory, Lemont, IL, USA.

Alexis A Rodriguez (AA)

Argonne National Laboratory, Lemont, IL, USA.

Yukai Xiao (Y)

Argonne National Laboratory, Lemont, IL, USA.

Xin Sheng (X)

Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Edward J Saunders (EJ)

The Institute of Cancer Research, London, UK.

Tokhir Dadaev (T)

The Institute of Cancer Research, London, UK.

Mark N Brook (MN)

The Institute of Cancer Research, London, UK.

Thomas J Hoffmann (TJ)

Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.

Kenneth Muir (K)

Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Peggy Wan (P)

Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Loic Le Marchand (L)

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.

Lynne Wilkens (L)

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.

Ying Wang (Y)

Department of Population Science, American Cancer Society, Atlanta, GA, USA.

Johanna Schleutker (J)

Institute of Biomedicine, University of Turku, Finland.

Robert J MacInnis (RJ)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.

Cezary Cybulski (C)

International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.

David E Neal (DE)

Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK.
University of Cambridge, Department of Oncology, Addenbrooke's Hospital, Cambridge, UK.
Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge UK.

Børge G Nordestgaard (BG)

Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Copenhagen, Denmark.

Sune F Nielsen (SF)

Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Copenhagen, Denmark.

Jyotsna Batra (J)

Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
Translational Research Institute, Brisbane, Queensland, Australia.

Judith A Clements (JA)

Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
Translational Research Institute, Brisbane, Queensland, Australia.

Henrik Grönberg (H)

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

Nora Pashayan (N)

University College London, Department of Applied Health Research, London, UK.
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.

Ruth C Travis (RC)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Jong Y Park (JY)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.

Demetrius Albanes (D)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Stephanie Weinstein (S)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Lorelei A Mucci (LA)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

David J Hunter (DJ)

Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Kathryn L Penney (KL)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.

Catherine M Tangen (CM)

SWOG Statistical Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Robert J Hamilton (RJ)

Dept. of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Canada.
Dept. of Surgery (Urology), University of Toronto, Canada.

Marie-Élise Parent (MÉ)

Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Laval, QC, Canada.
Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, QC, Canada.

Janet L Stanford (JL)

Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.

Stella Koutros (S)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Alicja Wolk (A)

Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Karina D Sørensen (KD)

Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.
Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark.

William J Blot (WJ)

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
International Epidemiology Institute, Rockville, MD, USA.

Edward D Yeboah (ED)

University of Ghana Medical School, Accra, Ghana.
Korle Bu Teaching Hospital, Accra, Ghana.

James E Mensah (JE)

University of Ghana Medical School, Accra, Ghana.
Korle Bu Teaching Hospital, Accra, Ghana.

Yong-Jie Lu (YJ)

Centre for Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, London, UK.

Daniel J Schaid (DJ)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Stephen N Thibodeau (SN)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Catharine M West (CM)

Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, UK.

Christiane Maier (C)

Humangenetik Tuebingen, Tuebingen, Germany.

Adam S Kibel (AS)

Division of Urologic Surgery, Brigham and Womens Hospital, Boston, MA, USA.

Géraldine Cancel-Tassin (G)

CeRePP, Tenon Hospital, Paris, France.
Sorbonne Universite, GRC 5 Predictive Onco-urology, Tenon Hospital, Paris, France.

Florence Menegaux (F)

"Exposome and Heredity", CESP (UMR 1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France.

Esther M John (EM)

Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Eli Marie Grindedal (EM)

Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.

Kay-Tee Khaw (KT)

Clinical Gerontology Unit, University of Cambridge, Cambridge, UK.

Sue A Ingles (SA)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Ana Vega (A)

Fundación Pública Galega Medicina Xenómica, Santiago De Compostela, Spain.
Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago De Compostela, Spain.
Centro de Investigación en Red de Enfermedades Raras (CIBERER), Spain.

Barry S Rosenstein (BS)

Department of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Manuel R Teixeira (MR)

Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.
Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.

Manolis Kogevinas (M)

ISGlobal, Barcelona, Spain.
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

Lisa Cannon-Albright (L)

Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA.

Chad Huff (C)

Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

Luc Multigner (L)

Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Rennes, France.

Radka Kaneva (R)

Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria.

Robin J Leach (RJ)

Department of Urology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio Texas, USA.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.

Ann W Hsing (AW)

Department of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Rick A Kittles (RA)

Division of Health Equities, Department of Population Sciences, City of Hope, Duarte, CA, USA.

Adam B Murphy (AB)

Department of Urology, Northwestern University, Chicago, IL, USA.

Christopher J Logothetis (CJ)

The University of Texas M. D. Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, TX, USA.

Susan L Neuhausen (SL)

Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.

William B Isaacs (WB)

James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD, USA.

Barbara Nemesure (B)

Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.

Anselm J Hennis (AJ)

Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.
Chronic Disease Research Centre and Faculty of Medical Sciences, University of the West Indies, Bridgetown, Barbados.

John Carpten (J)

Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Hardev Pandha (H)

Faculty of Health and Medical Sciences, The University of Surrey, Guildford, Surrey, UK.

Kim De Ruyck (K)

Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, Gent, Belgium.

Jianfeng Xu (J)

Program for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.

Azad Razack (A)

Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Soo-Hwang Teo (SH)

Cancer Research Malaysia (CRM), Outpatient Centre, Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia.

Lisa F Newcomb (LF)

Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Department of Urology, University of Washington, Seattle, WA, USA.

Jay H Fowke (JH)

Division of Epidemiology, Department of Preventive Medicine, The University of Tennessee Health Science Center, TN, USA.

Christine Neslund-Dudas (C)

Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.

Benjamin A Rybicki (BA)

Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.

Marija Gamulin (M)

Department of Oncology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.

Nawaid Usmani (N)

Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada.

Frank Claessens (F)

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Leuven, Belgium.

Manuela GagoDominguez (M)

Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS, Santiago de Compostela, Spain.
University of California San Diego, Moores Cancer Center, La Jolla, CA, USA.

Jose Esteban Castelao (JE)

Genetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IISGS), Vigo (Pontevedra), Spain.

Paul A Townsend (PA)

Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, UK.
The University of Surrey, Guildford, Surrey, UK.

Dana C Crawford (DC)

Case Western Reserve University, Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Cleveland, OH, USA.

Gyorgy Petrovics (G)

Center for Prostate Disease Research, Uniformed Services University, Bethesda, MD, USA.

Graham Casey (G)

Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.

Monique J Roobol (MJ)

109 Department of Urology, Erasmus University Medical Center, Cancer Institute, Rotterdam, The Netherlands.

Jennifer F Hu (JF)

The University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA.

Sonja I Berndt (SI)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Stephen K Van Den Eeden (SK)

Division of Research, Kaiser Permanente, Northern California, Oakland, CA, USA.
Department of Urology, University of California San Francisco, San Francisco, CA, USA.

Douglas F Easton (DF)

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Michael B Cook (MB)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Fredrik Wiklund (F)

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

John S Witte (JS)

Department of Epidemiology and Population Health, Department of Biomedical Data Science, Stanford Cancer Institute, Stanford, CA, USA.

Rosalind A Eeles (RA)

The Institute of Cancer Research, Sutton, London, UK.
Royal Marsden NHS Foundation Trust, London, UK.

Zsofia Kote-Jarai (Z)

The Institute of Cancer Research, Sutton, London, UK.

Stephen Watya (S)

School of Public Health, Makerere University College of Health Sciences, Kampala Uganda.

John M Gaziano (JM)

VA Boston Healthcare System, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Amy C Justice (AC)

VA Connecticut Healthcare System, West Haven, CT, USA.
Yale School of Medicine, New Haven, CT, USA.

David V Conti (DV)

Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Christopher A Haiman (CA)

Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Classifications MeSH