Infection-induced epilepsy is caused by increased expression of chondroitin sulfate proteoglycans in hippocampus and amygdala.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
17 May 2023
Historique:
pubmed: 9 6 2023
medline: 9 6 2023
entrez: 9 6 2023
Statut: epublish

Résumé

Alterations in the extracellular matrix (ECM) are common in epilepsy, yet whether they are cause or consequence of disease is unknow. Using Theiler's virus infection model of acquired epilepsy we find

Identifiants

pubmed: 37292901
doi: 10.1101/2023.05.16.541066
pmc: PMC10245664
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS036692
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS052634
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS082851
Pays : United States

Auteurs

Dipan C Patel (DC)

Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.

Nathaniel Swift (N)

Department of Internal Medicine, Gerontology and Geriatric Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.

Bhanu P Tewari (BP)

Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.

Jack L Browning (JL)

School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

Courtney Prim (C)

Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.

Lata Chaunsali (L)

Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.

Ian Kimbrough (I)

Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.

Michelle L Olsen (ML)

School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

Harald Sontheimer (H)

Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.

Classifications MeSH