Neurocognitive and neurophysiological endophenotypes in schizophrenia: An overview.
Endophenotypes
Psychosis
Schizophrenia
Journal
Biomarkers in neuropsychiatry
ISSN: 2666-1446
Titre abrégé: Biomark Neuropsychiatry
Pays: Netherlands
ID NLM: 101759453
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
medline:
1
12
2020
pubmed:
1
12
2020
entrez:
9
6
2023
Statut:
ppublish
Résumé
Schizophrenia (SCZ) is a severe psychotic disorder that affects up to 1% of the US population and it is associated with progressive impairment in social functioning and cognition. Nonetheless, despite its high burden, the pathophysiology of SCZ, including the genetic and biological mechanisms underlying the development and manifestation of the disorder, remains largely elusive. Endophenotypes are subtypes of biological markers that are more closely related to the genetic vulnerability for a disorder (e.g., SCZ). Recently, research on endophenotypes has identified several parameters that may prove useful in shedding light over the underlying neurobiology of SCZ. In this article, we provide an overview of the most established SCZ endophenotypes in the domains of neurocognition (attention deficits, working and verbal declarative memory dysfunctions) and neurophysiology (pre-pulse inhibition, anti-saccade impairment, event-related potential deficits) along with some novel, sleep-based measures (reduced sleep spindles and sleep slow waves). We also discuss recent conceptual advances in the field that may lead to novel, personalized treatment interventions for patients affected by this devastating mental illness.
Identifiants
pubmed: 37293386
doi: 10.1016/j.bionps.2020.100017
pmc: PMC10249673
mid: NIHMS1905394
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIMH NIH HHS
ID : R01 MH113827
Pays : United States
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflict of interest.
Références
Schizophr Bull. 1999;25(1):173-82
pubmed: 10098920
Biol Psychiatry. 1998 Apr 15;43(8):584-94
pubmed: 9564443
Schizophr Bull. 2007 Jan;33(1):49-68
pubmed: 17101692
JAMA Psychiatry. 2019 Nov 1;76(11):1187-1197
pubmed: 31389974
Psychopharmacology (Berl). 2001 Jul;156(2-3):234-58
pubmed: 11549226
Neuropsychopharmacology. 1995 Feb;12(1):3-16
pubmed: 7766284
Neuroscience. 2018 Aug 10;385:38-46
pubmed: 29906551
Schizophr Res. 2004 Oct 1;70(2-3):315-29
pubmed: 15329307
Curr Top Behav Neurosci. 2010;4:349-71
pubmed: 21312406
Am J Psychiatry. 1999 Sep;156(9):1358-66
pubmed: 10484945
BMC Psychiatry. 2017 Jan 13;17(1):12
pubmed: 28086761
Biol Psychiatry. 2003 Jun 15;53(12):1120-31
pubmed: 12814863
Arch Gen Psychiatry. 1992 Mar;49(3):206-15
pubmed: 1567275
Genome Med. 2018 Feb 22;10(1):11
pubmed: 29471866
Biol Psychiatry. 2002 Oct 1;52(7):749-58
pubmed: 12372666
Eur J Neurosci. 2018 Oct;48(8):2738-2758
pubmed: 29280209
Eur Arch Psychiatry Clin Neurosci. 2013 Nov;263 Suppl 2:S147-54
pubmed: 24071914
Acta Psychiatr Scand. 2010 Sep;122(3):235-45
pubmed: 20105148
J Psychiatr Res. 2010 Jan;44(2):112-20
pubmed: 19665729
Am J Psychiatry. 2010 Jul;167(7):748-51
pubmed: 20595427
Biomark Med. 2017 Sep;11(9):769-780
pubmed: 28891303
Biol Psychiatry. 2014 Mar 15;75(6):459-69
pubmed: 24050720
J Psychiatr Res. 2019 Jun;113:39-44
pubmed: 30878791
JAMA Psychiatry. 2016 Dec 01;73(12):1239-1248
pubmed: 27806157
Science. 1992 Jan 31;255(5044):556-9
pubmed: 1736359
J Nerv Ment Dis. 1996 Jun;184(6):331-8
pubmed: 8642381
Front Hum Neurosci. 2014 Oct 07;8:762
pubmed: 25339881
Biol Psychiatry. 2015 Jan 15;77(2):127-36
pubmed: 24923619
Sleep. 2008 Feb;31(2):204-11
pubmed: 18274267
J Abnorm Psychol. 1997 May;106(2):203-12
pubmed: 9131840
Eur Arch Psychiatry Clin Neurosci. 2017 Apr;267(3):213-224
pubmed: 27565806
Sleep Med Rev. 2017 Apr;32:69-84
pubmed: 27061476
Neuropsychology. 2008 Sep;22(5):606-17
pubmed: 18763880
Br J Psychiatry. 2009 Mar;194(3):243-51
pubmed: 19252155
Am J Psychiatry. 2007 Mar;164(3):483-92
pubmed: 17329474
Schizophr Res. 2019 Apr;206:318-324
pubmed: 30377012
Psychiatry Res. 2009 Oct 30;169(3):212-9
pubmed: 19748132
Am J Psychiatry. 2015 May;172(5):466-78
pubmed: 25615564
Schizophr Res. 2009 Apr;109(1-3):24-37
pubmed: 19223268
Biol Psychiatry. 2000 Jan 1;47(1):61-70
pubmed: 10650450
Schizophr Bull. 2015 Nov;41(6):1336-48
pubmed: 26012519
Neuroscience. 2005;132(2):529-35
pubmed: 15802203
Biol Psychiatry. 2011 May 15;69(10):959-66
pubmed: 21167475
Schizophr Res. 1998 May 25;31(2-3):89-98
pubmed: 9689713
Schizophr Res. 2015 Apr;163(1-3):73-9
pubmed: 25682549
Schizophr Res. 2007 Sep;95(1-3):54-60
pubmed: 17656071
Neuropsychol Rev. 2018 Dec;28(4):509-533
pubmed: 30343458
Arch Gen Psychiatry. 1991 Jul;48(7):618-24
pubmed: 2069492
Schizophr Bull. 2000;26(1):119-36
pubmed: 10755673
J Abnorm Psychol. 2005 Nov;114(4):599-611
pubmed: 16351383
Schizophr Res. 2009 May;110(1-3):1-23
pubmed: 19328655
Lancet. 2017 Sep 16;390(10100):1211-1259
pubmed: 28919117
Brain. 2020 Mar 1;143(3):1027-1038
pubmed: 32103250
Clin Psychol Rev. 2015 Dec;42:96-115
pubmed: 26407540
Biol Psychiatry. 1991 Nov 15;30(10):1059-62
pubmed: 1756198
Transl Psychiatry. 2017 Oct 24;7(10):e1249
pubmed: 29064472
Am J Psychiatry. 2010 Nov;167(11):1339-48
pubmed: 20843876
Curr Pharm Des. 2013;19(36):6462-79
pubmed: 23432712
Biol Psychiatry. 2016 Oct 15;80(8):599-608
pubmed: 26602589
Schizophr Res. 2013 May;146(1-3):10-6
pubmed: 23498153
Psychiatry Res. 1989 Jul;29(1):65-85
pubmed: 2772099
Lancet. 2013 Sep 14;382(9896):951-62
pubmed: 23810019
World Psychiatry. 2019 Feb;18(1):67-76
pubmed: 30600629
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Biomark Neuropsychiatry. 2019 Dec;1:
pubmed: 36643612
Arch Gen Psychiatry. 2010 Mar;67(3):241-51
pubmed: 20194824
Clin Neurophysiol. 2007 Oct;118(10):2128-48
pubmed: 17573239
Schizophr Bull. 2015 Jan;41(1):15-9
pubmed: 25394665
Neurosci Biobehav Rev. 2011 Apr;35(5):1154-65
pubmed: 21167865
Clin Neurophysiol. 1999 Sep;110(9):1601-10
pubmed: 10479027
Schizophr Res. 2014 Feb;152(2-3):503-12
pubmed: 24405980
Neuron. 2002 Jul 3;35(1):205-11
pubmed: 12123620
Schizophr Bull. 2004;30(4):739-54
pubmed: 15957196
Arch Gen Psychiatry. 2003 Dec;60(12):1187-92
pubmed: 14662550
Biol Psychiatry. 2003 Apr 1;53(7):624-6
pubmed: 12679242
Biol Psychiatry. 2012 Jan 15;71(2):154-61
pubmed: 21967958
Psychiatry Res. 2000 Sep 11;95(3):215-25
pubmed: 10974360
Am J Psychiatry. 2016 Apr 1;173(4):373-84
pubmed: 26651391
Curr Psychiatry Rep. 2003 Aug;5(4):299-302
pubmed: 12857533
Arch Gen Psychiatry. 2007 Nov;64(11):1242-50
pubmed: 17984393
Schizophr Res. 2004 Nov 1;71(1):113-25
pubmed: 15374579
Schizophr Res. 2018 Aug;198:6-15
pubmed: 28549722
Schizophr Bull. 2007 Jan;33(1):69-94
pubmed: 17135482
Arch Gen Psychiatry. 1998 May;55(5):443-8
pubmed: 9596047
Clin Psychopharmacol Neurosci. 2020 Feb 29;18(1):127-135
pubmed: 31958913
Am J Psychiatry. 1999 Jul;156(7):1046-51
pubmed: 10401450
J Consult Psychol. 1956 Oct;20(5):343-50
pubmed: 13367264
Am J Psychiatry. 2013 Nov;170(11):1275-84
pubmed: 23771174
Genes Brain Behav. 2006 Mar;5(2):113-9
pubmed: 16507002
Am J Psychiatry. 2019 Jan 1;176(1):3-4
pubmed: 30848945
Biol Psychiatry. 2018 Mar 15;83(6):492-498
pubmed: 28987712
Nat Genet. 2018 Mar;50(3):381-389
pubmed: 29483656
Bipolar Disord. 2006 Apr;8(2):117-23
pubmed: 16542181
Schizophr Res. 2005 Jul 1;76(1):1-23
pubmed: 15927795
J Psychiatr Res. 2008 Oct;42(13):1086-93
pubmed: 18280502
Nature. 2009 Aug 6;460(7256):753-7
pubmed: 19571809
Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):295-300
pubmed: 11134520
Am J Psychiatry. 2013 Nov;170(11):1263-74
pubmed: 23846857
Schizophr Bull. 2008 Jul;34(4):760-73
pubmed: 18502737
Sleep Med Rev. 2018 Oct;41:113-132
pubmed: 29490885
Biol Psychiatry. 1997 Jun 15;41(12):1196-210
pubmed: 9171910
Psychiatry Res. 1988 Nov;26(2):223-38
pubmed: 3237915
Acta Psychiatr Scand. 2018 Aug;138(2):163-172
pubmed: 29974456
Am J Psychiatry. 2003 Apr;160(4):636-45
pubmed: 12668349
Schizophr Res. 2020 Jul;221:29-36
pubmed: 31753592
Front Syst Neurosci. 2019 Feb 13;13:3
pubmed: 30814938
Nat Commun. 2017 Jun 26;8:15930
pubmed: 28649997
Schizophr Res. 2020 Feb;216:357-366
pubmed: 31796306
J Psychiatr Brain Sci. 2019;4(2):
pubmed: 31245629
NPJ Schizophr. 2018 Feb 9;4(1):2
pubmed: 29426848
Schizophr Bull. 2018 Apr 6;44(3):492-504
pubmed: 29036701
Nat Neurosci. 2009 Apr;12(4):396-7
pubmed: 18836440
Schizophr Bull. 2006 Jul;32(3):498-506
pubmed: 16687386
Psychiatry Res. 2010 Jul 30;178(2):236-43
pubmed: 20483176
Neuropsychol Rev. 2003 Jun;13(2):43-77
pubmed: 12887039
Science. 1983 Apr 15;220(4594):327-9
pubmed: 6836276
Psychol Med. 2018 Jun;48(8):1325-1340
pubmed: 29094675
Neuroimage. 2005 Oct 1;27(4):960-8
pubmed: 16009570
Dev Psychopathol. 1999 Summer;11(3):487-508
pubmed: 10532621
Curr Biol. 2018 Jun 4;28(11):R656-R658
pubmed: 29870702
Schizophr Res. 2004 Dec 1;71(2-3):285-95
pubmed: 15474899
J Manag Care Pharm. 2013 Jul-Aug;19(6):468-77
pubmed: 23806061