Safety and efficacy of the feed additive 4-methyl-5-vinylthiazole [15.018] belonging to chemical group 29 for all animal species (FEFANA asbl).

4‐methyl‐5‐vinylthiazole efficacy feed flavourings safety sensory additives thiazoles thiophene and thiazoline

Journal

EFSA journal. European Food Safety Authority
ISSN: 1831-4732
Titre abrégé: EFSA J
Pays: United States
ID NLM: 101642076

Informations de publication

Date de publication:
Jun 2023
Historique:
medline: 9 6 2023
pubmed: 9 6 2023
entrez: 9 6 2023
Statut: epublish

Résumé

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 4-methyl-5-vinylthiazole [15.018] belonging to chemical group 29 (thiazoles, thiophene and thiazoline), when used as sensory additive (flavourings) in feed for all animal species. The FEEDAP Panel concluded that 4-methyl-5-vinylthiazole [15.018] was safe at the maximum proposed use level of 0.5 mg/kg complete feed for veal calves (milk replacer), dogs, salmonids and ornamental fish. For the other species, the calculated safe concentrations in complete feed are: 0.4 mg/kg for cattle for fattening, sheep/goat, horses and cats; 0.3 mg/kg for sows and dairy cows; 0.2 mg/kg for piglets, pigs for fattening, rabbits and laying hens; and 0.1 mg/kg for chickens for fattening and turkeys for fattening. These conclusions were extrapolated to other physiologically related species. For any other species, the additive was considered safe at 0.1 mg/kg complete feed. No safety concern would arise for the consumer from the use the additive up to the maximum proposed use level in feed. The additive should be considered as irritant to skin and eyes and the respiratory tract, and as dermal and respiratory sensitisers. The use of 4-methyl-5-vinylthiazole [15.018] as a flavour in animal feed was not expected to pose a risk to the environment. Since the compound under assessment is used in food as flavouring and its function in feed is essentially the same as that in food, no further demonstration of efficacy was considered necessary.

Identifiants

pubmed: 37293568
doi: 10.2903/j.efsa.2023.8051
pii: EFS28051
pmc: PMC10245293
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e08051

Informations de copyright

© 2023 European Food Safety Authority. EFSA Journal published by Wiley‐VCH GmbH on behalf of European Food Safety Authority.

Références

Food Cosmet Toxicol. 1969 Jul;7(4):405-7
pubmed: 5350101
EFSA J. 2018 May 07;16(5):e05274
pubmed: 32625911
EFSA J. 2019 Apr 05;17(4):e05648
pubmed: 32626279
EFSA J. 2017 Oct 17;15(10):e05023
pubmed: 32625313
EFSA J. 2017 Oct 17;15(10):e05021
pubmed: 32625311
EFSA J. 2023 Jun 07;21(6):e08051
pubmed: 37293568

Auteurs

Classifications MeSH