The role of apoptosis in the pathogenesis of osteoarthritis.
Apoptosis
Autophagy
Non-coding RNAs
Osteoarthritis
Senescence
Signaling pathways
Journal
International orthopaedics
ISSN: 1432-5195
Titre abrégé: Int Orthop
Pays: Germany
ID NLM: 7705431
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
02
04
2022
accepted:
17
05
2023
medline:
17
7
2023
pubmed:
9
6
2023
entrez:
9
6
2023
Statut:
ppublish
Résumé
Apoptosis is an important physiological process, making a great difference to development and tissue homeostasis. Osteoarthritis (OA) is a chronic joint disease characterized by degeneration and destruction of articular cartilage and bone hyperplasia. This purpose of this study is to provide an updated review of the role of apoptosis in the pathogenesis of osteoarthritis. A comprehensive review of the literature on osteoarthritis and apoptosis was performed, which mainly focused on the regulatory factors and signaling pathways associated with chondrocyte apoptosis in osteoarthritis and other pathogenic mechanisms involved in chondrocyte apoptosis. Inflammatory mediators such as reactive oxygen species (ROS), nitric oxide (NO), IL-1β, tumor necrosis factor-α (TNF-α), and Fas are closely related to chondrocyte apoptosis. NF-κB signaling pathway, Wnt signaling pathway, and Notch signaling pathway activate proteins and gene targets that promote or inhibit the progression of osteoarthritis disease, including chondrocyte apoptosis and ECM degradation. Long non-coding RNAs (LncRNAs) and microRNAs (microRNAs) have gradually replaced single and localized research methods and become the main research approaches. In addition, the relationship between cellular senescence, autophagy, and apoptosis was also briefly explained. This review offers a better molecular delineation of apoptotic processes that may help in designing new therapeutic options for OA treatment.
Identifiants
pubmed: 37294429
doi: 10.1007/s00264-023-05847-1
pii: 10.1007/s00264-023-05847-1
doi:
Substances chimiques
MicroRNAs
0
Interleukin-1beta
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1895-1919Subventions
Organisme : Science and Technology Support Program of Jiangsu Province
ID : BE2022801
Organisme : Government of Jiangsu Province
ID : SJCX21_0727
Informations de copyright
© 2023. The Author(s) under exclusive licence to SICOT aisbl.
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