Endemic Systemic Mycoses in Italy: A Systematic Review of Literature and a Practical Update.


Journal

Mycopathologia
ISSN: 1573-0832
Titre abrégé: Mycopathologia
Pays: Netherlands
ID NLM: 7505689

Informations de publication

Date de publication:
Aug 2023
Historique:
received: 17 12 2022
accepted: 02 04 2023
medline: 31 7 2023
pubmed: 9 6 2023
entrez: 9 6 2023
Statut: ppublish

Résumé

Endemic systemic mycoses such as blastomycosis, coccidioidomycosis, histoplasmosis, talaromycosis, paracoccidioidomycosis are emerging as an important cause of morbidity and mortality worldwide. We conducted a systematic review on endemic systemic mycoses reported in Italy from 1914 to nowadays. We found out: 105 cases of histoplasmosis, 15 of paracoccidioidomycosis, 10 of coccidioidomycosis, 10 of blastomycosis and 3 of talaromycosis. Most cases have been reported in returning travelers and expatriates or immigrants. Thirtytwo patients did not have a story of traveling to an endemic area. Fortysix subjects had HIV/AIDS. Immunosuppression was the major risk factor for getting these infections and for severe outcomes. We provided an overview on microbiological characteristics and clinical management principles of systemic endemic mycoses with a focus on the cases reported in Italy.

Identifiants

pubmed: 37294504
doi: 10.1007/s11046-023-00735-z
pii: 10.1007/s11046-023-00735-z
pmc: PMC10386973
doi:

Types de publication

Systematic Review Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

307-334

Informations de copyright

© 2023. The Author(s).

Références

Bonifaz A, Vázquez-González D, Perusquía-Ortiz AM. Endemic systemic mycoses: coccidioidomycosis, histoplasmosis, paracoccidioidomycosis and blastomycosis. J Dtsch Dermatol Ges. 2011;9:705–14 (quiz 715).
pubmed: 21722309
Gauthier GM. Fungal dimorphism and virulence: molecular mechanisms for temperature adaptation, immune evasion, and in vivo survival. Mediat Inflamm. 2017;2017:8491383.
doi: 10.1155/2017/8491383
Thompson GR 3rd, Le T, Chindamporn A, et al. Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology. Lancet Infect Dis. 2021;21:e364–74.
pubmed: 34364529 pmcid: 9450022 doi: 10.1016/S1473-3099(21)00191-2
Antinori S, Giacomelli A, Corbellino M, et al. Histoplasmosis diagnosed in Europe and Israel: a case report and systematic review of the literature from 2005 to 2020. J Fungi. 2021. https://doi.org/10.3390/jof7060481 .
doi: 10.3390/jof7060481
Ashraf N, Kubat RC, Poplin V, et al. Re-drawing the maps for endemic mycoses. Mycopathologia. 2020;185:843–65.
pubmed: 32040709 pmcid: 7416457 doi: 10.1007/s11046-020-00431-2
Antinori S, Magni C, Nebuloni M, et al. Histoplasmosis among human immunodeficiency virus-infected people in Europe: report of 4 cases and review of the literature. Medicine. 2006;85:22–36.
pubmed: 16523050 doi: 10.1097/01.md.0000199934.38120.d4
Farina C, Rizzi M, Ricci L, et al. Imported and autochthonous histoplasmosis in Italy: new cases and old problems. Rev Iberoam Micol. 2005;22:169–71.
pubmed: 16309355 doi: 10.1016/S1130-1406(05)70034-6
Farina C, Gnecchi F, Michetti G, et al. Imported and autochthonous histoplasmosis in Bergamo province, Northern Italy. Scand J Infect Dis. 2000;32:271–4.
pubmed: 10879597 doi: 10.1080/00365540050165901
Wagner G, Moertl D, Glechner A, et al. Paracoccidioidomycosis diagnosed in Europe—a systematic literature review. J Fungi. 2021. https://doi.org/10.3390/jof7020157 .
doi: 10.3390/jof7020157
Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097.
pubmed: 19621072 pmcid: 2707599 doi: 10.1371/journal.pmed.1000097
Cao C, Xi L, Chaturvedi V. Talaromycosis (Penicilliosis) due to Talaromyces (Penicillium) marneffei: insights into the clinical trends of a major fungal disease 60 years after the discovery of the pathogen. Mycopathologia. 2019;184:709–20.
pubmed: 31811603 doi: 10.1007/s11046-019-00410-2
Ustianowski AP, Sieu TPM, Day JN. Penicillium marneffei infection in HIV. Curr Opin Infect Dis. 2008;21:31–6.
pubmed: 18192783 doi: 10.1097/QCO.0b013e3282f406ae
Sirisanthana V, Sirisanthana T. Disseminated Penicillium marneffei infection in human immunodeficiency virus-infected children. Pediatr Infect Dis J. 1995;14:935–40.
pubmed: 8584358 doi: 10.1097/00006454-199511000-00003
Kawila R, Chaiwarith R, Supparatpinyo K. Clinical and laboratory characteristics of penicilliosis marneffei among patients with and without HIV infection in Northern Thailand: a retrospective study. BMC Infect Dis. 2013;13:464.
pubmed: 24094273 pmcid: 3851520 doi: 10.1186/1471-2334-13-464
Supparatpinyo K, Khamwan C, Baosoung V, et al. Disseminated Penicillium marneffei infection in Southeast Asia. Lancet. 1994;344:110–3.
pubmed: 7912350 doi: 10.1016/S0140-6736(94)91287-4
Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents Recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America; 2009
Viviani MA, Tortorano AM, Rizzardini G, et al. Treatment and serological studies of an Italian case of penicilliosis marneffei contracted in Thailand by a drug addict infected with the human immunodeficiency virus. Eur J Epidemiol. 1993;9:79–85.
pubmed: 8472804 doi: 10.1007/BF00463094
Antinori S, Gianelli E, Bonaccorso C, et al. Disseminated Penicillium marneffei infection in an HIV-positive Italian patient and a review of cases reported outside endemic regions. J Travel Med. 2006;13:181–8.
pubmed: 16706952 doi: 10.1111/j.1708-8305.2006.00039.x
Basile G, Piccica M, Vellere I, et al. Disseminated talaromyces infection in an AIDS patient. Clin Microbiol Infect. 2022;28:64–5.
pubmed: 33813123 doi: 10.1016/j.cmi.2021.03.017
Dukik K, Muñoz JF, Jiang Y, et al. Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales). Mycoses. 2017. https://doi.org/10.1111/myc.12601 .
doi: 10.1111/myc.12601 pubmed: 28176377 pmcid: 5775888
Brown EM, McTaggart LR, Zhang SX, et al. Phylogenetic analysis reveals a cryptic species Blastomyces gilchristii, sp. nov. within the human pathogenic fungus Blastomyces dermatitidis. PLoS ONE. 2013. https://doi.org/10.1371/journal.pone.0059237 .
doi: 10.1371/journal.pone.0059237 pubmed: 24391972 pmcid: 3877356
Schwartz IS, Wiederhold NP, Hanson KE, et al. Blastomyces helicus, a new dimorphic fungus causing fatal pulmonary and systemic disease in humans and animals in Western Canada and the United States. Clin Infect Dis. 2019. https://doi.org/10.1093/cid/ciy483 .
doi: 10.1093/cid/ciy483 pubmed: 31505629 pmcid: 6736400
Baily GG, Robertson VJ, Neill P, et al. Blastomycosis in Africa: clinical features, diagnosis, and treatment. Clin Infect Dis. 1991;13:1005–8.
doi: 10.1093/clinids/13.5.1005
Randhawa HS, Chowdhary A, Kathuria S, et al. Blastomycosis in India: report of an imported case and current status. Med Mycol. 2013. https://doi.org/10.3109/13693786.2012.685960 .
doi: 10.3109/13693786.2012.685960 pubmed: 22646243
Codifava M, Guerra A, Rossi G, et al. Unusual osseous presentation of blastomycosis in an immigrant child: a challenge for European pediatricians. Ital J Pediatr. 2012. https://doi.org/10.1186/1824-7288-38-69 .
doi: 10.1186/1824-7288-38-69 pubmed: 23228191 pmcid: 3545834
Saccente M, Woods GL. Clinical and laboratory update on blastomycosis. Clin Microbiol Rev. 2010;23:367–81.
pubmed: 20375357 pmcid: 2863359 doi: 10.1128/CMR.00056-09
Shelnutt LM, Kaneene JB, Carneiro PAM, et al. Prevalence, distribution, and risk factors for canine blastomycosis in Michigan, USA. Med Mycol. 2019;58:609–16.
pmcid: 7326585 doi: 10.1093/mmy/myz110
Klein BS, Vergeront JM, Davis JP. Epidemiologic aspects of blastomycosis, the enigmatic systemic mycosis. Semin Respir Infect. 1986;1:29–39.
pubmed: 3317597
Bradsher RW Jr. The endemic mimic: blastomycosis an illness often misdiagnosed. Trans Am Clin Climatol Assoc. 2014;125:188–202 (discussion 202–3).
pubmed: 25125734 pmcid: 4112704
Mazi PB, Rauseo AM, Spec A. Blastomycosis. Infect Dis Clin North Am. 2021;35:515–30.
pubmed: 34016289 doi: 10.1016/j.idc.2021.03.013
Girouard G, Lachance C, Pelletier R. Observations on (1–3)-beta-D-glucan detection as a diagnostic tool in endemic mycosis caused by Histoplasma or Blastomyces. J Med Microbiol. 2007;56:1001–2.
pubmed: 17577071 doi: 10.1099/jmm.0.47162-0
Limper AH, Knox KS, Sarosi GA, et al. An official American thoracic society statement: treatment of fungal infections in adult pulmonary and critical care patients. Am J Respir Crit Care Med. 2011;183:96–128.
pubmed: 21193785 doi: 10.1164/rccm.2008-740ST
Chapman SW, Dismukes WE, Proia LA, et al. Clinical practice guidelines for the management of blastomycosis: 2008 update by the Infectious Diseases Society of America. Clin Infect Dis. 2008;46:1801–12.
pubmed: 18462107 doi: 10.1086/588300
Ietto G, Baj A, Parise C, et al. Blastomycosis of the psoas muscles. IDCases. 2021;24:e01156.
pubmed: 34026543 pmcid: 8134727 doi: 10.1016/j.idcr.2021.e01156
Cavalot AL, Cravero L, Valente G, et al. Blastomycosis of the cervicofacial area: a review of the literature and case report. Acta Otorhinolaryngol Ital. 1992;12:605–10.
pubmed: 1339153
Sgobbi S, Bellando-Randone P. Systemic North American blastomycosis. Chir Organi Mov. 1978;64:439–46.
pubmed: 752621
Florenzano G, Zini F. Experimental observations on the etiology of a granulomatous pulmonary blastomycosis. Sperimentale. 1950;100:139–56.
pubmed: 15424779
Rivasi F, Nanetti A, Cesinaro AM, et al. Histopathological evidence of North American blastomycosis in Italy: report of two cases. APMIS. 2000;108:273–5.
pubmed: 10843414 doi: 10.1034/j.1600-0463.2000.d01-55.x
Chasen W. Two cases of facial blastomycosis. Riv Ital Stomatol. 1951;6:1040–7.
pubmed: 14912882
Rimondi AP, Bianchini E, Barucchello G, et al. Addison’s disease caused by adrenal blastomycosis: a case report with fine needle aspiration (FNA) cytology. Cytopathology. 1995;6:277–9.
pubmed: 8520008 doi: 10.1111/j.1365-2303.1995.tb00480.x
Ta F, Jw W, Oa P. South American blastomycosis or paracoccidioidycosis: the mycosis of Lutz, Splendore, and Almeida. AMA Arch Derm Syphilol. 1954. https://doi.org/10.1001/archderm.1954.01540200026003 .
doi: 10.1001/archderm.1954.01540200026003
Turissini DA, Gomez OM, Teixeira MM, et al. Species boundaries in the human pathogen Paracoccidioides. Fungal Genet Biol. 2017;106:9–25.
pubmed: 28602831 pmcid: 8335726 doi: 10.1016/j.fgb.2017.05.007
Mavengere H, Mattox K, Teixeira MM, et al. Genomes reflect high levels of species divergence and little interspecific gene flow. MBio. 2020. https://doi.org/10.1128/mBio.01999-20 .
doi: 10.1128/mBio.01999-20 pubmed: 33443110 pmcid: 8534288
Martinez R. New trends in paracoccidioidomycosis epidemiology. J Fungi. 2017. https://doi.org/10.3390/jof3010001 .
doi: 10.3390/jof3010001
Queiroz-Telles F, Escuissato DL. Pulmonary paracoccidioidomycosis. Semin Respir Crit Care Med. 2011;32:764–74.
pubmed: 22167404 doi: 10.1055/s-0031-1295724
de Queiroz-Telles FV, Peçanha Pietrobom PM, Rosa Júnior M, et al. New insights on pulmonary paracoccidioidomycosis. Semin Respir Crit Care Med. 2020;41:53–68.
pubmed: 32000284 doi: 10.1055/s-0039-3400544
Ferreira CS, de Castro Ribeiro EM, de Miranda GA, et al. Current strategies for diagnosis of paracoccidioidomycosis and prospects of methods based on gold nanoparticles. Future Microbiol. 2016;11:973–85.
doi: 10.2217/fmb-2016-0062
Teles FRR, Martins ML. Laboratorial diagnosis of paracoccidioidomycosis and new insights for the future of fungal diagnosis. Talanta. 2011;85:2254–64.
pubmed: 21962643 doi: 10.1016/j.talanta.2011.07.099
de Azevedo Melo AS, de Castro Lima Santos DW, Lima SL, et al. Evaluation of (1 → 3)-β-D-glucan assay for diagnosing paracoccidioidomycosis. Mycoses. 2020;63:38–42.
doi: 10.1111/myc.13007
Shikanai-Yasuda MA, Mendes RP, Colombo AL, et al. Brazilian guidelines for the clinical management of paracoccidioidomycosis. Epidemiol Serv Saude. 2018;27:e0500001.
pubmed: 30133688
Borges SRC, da Silva GMS, da Chambela MC, et al. Itraconazole vs. trimethoprim-sulfamethoxazole: a comparative cohort study of 200 patients with paracoccidioidomycosis. Med Mycol. 2014;52:303–10.
pubmed: 24577007 doi: 10.1093/mmy/myt012
Dalla Favera GB. Per la conoscenza della cosidetta blastomicosi cutanea (con un’osservazione personale di oidiomicosi (Gilchrist, Bushke) zimonematosi (de Beurmann et Gougerot). Giorn Ital Mal Ven Pelle. 1914;55:650–729.
Farris G. Report on a case of paracoccidioidomycosis (so-called Brazilian blastomycosis). G Ital Dermatol. 1955;96:321–58.
pubmed: 13285711
Solaroli C, Alol F, Becchis G, Zina A, Pippione M. Paracoceidioidomycosis description of a case. G Ital Dermatol Venereol. 1998;133:51–4.
Finzi FF, Bubola D, Lasagni A. Blastomicosi sudamericana. Ann Ital Dermatol Clin Sper. 1980;34:277–85.
Bertaccini G. Contributo allo studio della cosi detta blastomicosa sud-americana. Giorn Ital Dermatol Sifil. 1934;75:783–828.
Pecoraro C, Pinto A, Tortora G, et al. A case of South American blastomycosis of the bones and the lungs. Radiol Med. 1998;95:521–3.
pubmed: 9687934
Fulciniti F, Troncone G, Fazioli F, et al. Osteomyelitis by Paracoccidioides brasiliensis (South American blastomycosis): cytologic diagnosis on fine-needle aspiration biopsy smears: a case report. Diagn Cytopathol. 1996;15:442–6.
pubmed: 8989552 doi: 10.1002/(SICI)1097-0339(199612)15:5<442::AID-DC18>3.0.CO;2-N
Borgia G, Reynaud L, Cerini R, et al. A case of paracoccidioidomycosis: experience with long-term therapy. Infection. 2000;28:119–20.
pubmed: 10782401 doi: 10.1007/s150100050060
Cuomo A, Capra R, Di Gregorio A, Garavaldi G. On one case of South American blastomycosis with peculiar evolution. Riv Patol Clin Tuberc Pneumol. 1985;56:453–72.
Molese A, Pane A. South American blastomycosis (Lutz–Splendore–Almeida disease). Acta Med Ital Mal Infett Parassit. 1957;12:275–98.
pubmed: 13487216
Benoldi D, Alinovi A, Pezzarossa E, et al. Paracoccidioidomycosis (South American blastomycosis): a report of an imported case previously diagnosed as tuberculosis. Eur J Epidemiol. 1985;1:150–2.
pubmed: 3842361 doi: 10.1007/BF00141809
Scarpa C, Nini G, Gualdi G. Clinico-radiological contribution to the study of paracoccidioidomycosis. Minerva Dermatol. 1965;40:413–21.
pubmed: 5881682
Schiraldi O, Grimaldi N. Granulomatosi paracoccidioide. Policlinico. 1963;70:65–84.
Chaturvedi S, Victor TR, Marathe A, et al. Real-time PCR assay for detection and differentiation of Coccidioides immitis and Coccidioides posadasii from culture and clinical specimens. PLoS Negl Trop Dis. 2021. https://doi.org/10.1371/journal.pntd.0009765 .
doi: 10.1371/journal.pntd.0009765 pubmed: 34529679 pmcid: 8486383
Johnson RH, Sharma R, Kuran R, et al. Coccidioidomycosis: a review. J Investig Med. 2021;69:316–23.
pubmed: 33495302 pmcid: 7848065 doi: 10.1136/jim-2020-001655
McCotter OZ, Benedict K, Engelthaler DM, et al. Update on the Epidemiology of coccidioidomycosis in the United States. Med Mycol. 2019;57:S30-40.
pubmed: 30690599 doi: 10.1093/mmy/myy095
Sutton DA. Diagnosis of coccidioidomycosis by culture: safety considerations, traditional methods, and susceptibility testing. Ann N Y Acad Sci. 2007;1111:315–25.
pubmed: 17363439 doi: 10.1196/annals.1406.005
Zangeneh TT, Malo J, Luraschi-Monjagatta C, et al. Positive (1–3) B-d-glucan and cross reactivity of fungal assays in coccidioidomycosis. Med Mycol. 2015;53:171–3.
pubmed: 25541557 doi: 10.1093/mmy/myu077
Galgiani JN, Ampel NM, Blair JE, et al. 2016 Infectious Diseases Society of America (IDSA) clinical practice guideline for the treatment of coccidioidomycosis. Clin Infect Dis. 2016;63:e112–46.
pubmed: 27470238 doi: 10.1093/cid/ciw360
D’Avino A, Di Giambenedetto S, Fabbiani M, et al. Coccidioidomycosis of cervical lymph nodes in an HIV-infected patient with immunologic reconstitution on potent HAART: a rare observation in a nonendemic area. Diagn Microbiol Infect Dis. 2012;72:185–7.
pubmed: 22104185 doi: 10.1016/j.diagmicrobio.2011.10.002
Gobbi F, Angheben A, Farina C, et al. Coccidioidomycosis: first imported case in Italy. J Travel Med. 2012;19:192–4.
pubmed: 22530829 doi: 10.1111/j.1708-8305.2012.00599.x
Sotgiu G, Corbelli G. Osservazione dei primi due casi di istoplasmosi in Italia e di un caso di coccidioidomicosi. Bull Sci Med. 1955;127:85–92.
Tortorano AM, Carminati G, Tosoni A, et al. Primary cutaneous coccidioidomycosis in an Italian Nun working in South America and review of published literature. Mycopathologia. 2015;180:229–35.
pubmed: 25935662 doi: 10.1007/s11046-015-9895-0
Corpolongo A, Giancola ML, Ghirga P, et al. An imported case of acute pulmonary coccidioidomycosis in an Italian traveller. Infection. 2014;42:921–4.
pubmed: 24771415 doi: 10.1007/s15010-014-0614-4
Scanarini M, Rotilio A, Rigobello L, et al. Primary intrasellar coccidioidomycosis simulating a pituitary adenoma. Neurosurgery. 1991;28:748–51.
pubmed: 1876258 doi: 10.1227/00006123-199105000-00022
Vilardo S, Cavalcanti U, Mancuso E. On a case of coccidioidomycos. Gazz Int Med Chir. 1964;68:2307–20.
pubmed: 14277368
Rodrigues AM, Beale MA, Hagen F, et al. The global epidemiology of emerging Histoplasma species in recent years. Stud Mycol. 2020;97:100095.
pubmed: 33335607 pmcid: 7714791 doi: 10.1016/j.simyco.2020.02.001
Taylor ML, del Rocío Reyes-Montes M, Estrada-Bárcenas DA, et al. Considerations about the geographic distribution of histoplasma species. Appl Environ Microbiol. 2022. https://doi.org/10.1128/aem.02010-21 .
doi: 10.1128/aem.02010-21 pubmed: 35262368 pmcid: 9004366
Sepúlveda VE, Márquez R, Turissini DA, et al. Genome sequences reveal cryptic speciation in the human pathogen Histoplasma capsulatum. MBio. 2017;8(6):e01339-e1417. https://doi.org/10.1128/mBio.01339-17 .
doi: 10.1128/mBio.01339-17 pubmed: 29208741 pmcid: 5717386
Bahr NC, Antinori S, Joseph Wheat L, et al. Histoplasmosis infections worldwide: thinking outside of the Ohio River Valley. Curr Trop Med Rep. 2015;2:70–80.
pubmed: 26279969 pmcid: 4535725 doi: 10.1007/s40475-015-0044-0
Confalonieri M, Nanetti A, Gandola L, et al. Histoplasmosis capsulati in Italy: autochthonous or imported? Eur J Epidemiol. 1994;10:435–9.
pubmed: 7843347 doi: 10.1007/BF01719668
Araúz AB, Papineni P. Histoplasmosis. Infect Dis Clin North Am. 2021;35:471–91.
pubmed: 34016287 doi: 10.1016/j.idc.2021.03.011
Kauffman C, Miceli M. Histoplasmosis and blastomycosis in solid organ transplant recipients. J Fungi. 2015;1:94–106.
doi: 10.3390/jof1020094
Zanotti P, Chirico C, Gulletta M, et al. Disseminated Histoplasmosis as AIDS-presentation. Case report and comprehensive review of current literature. Mediterr J Hematol Infect Dis. 2018;10:e2018040.
pubmed: 30002796 pmcid: 6039081 doi: 10.4084/mjhid.2018.040
Azar MM, Hage CA. Laboratory diagnostics for histoplasmosis. J Clin Microbiol. 2017;55:1612–20.
pubmed: 28275076 pmcid: 5442517 doi: 10.1128/JCM.02430-16
Donnelly JP, Chen SC, Kauffman CA, et al. Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis. 2019;71:1367–76.
pmcid: 7486838 doi: 10.1093/cid/ciz1008
Bloch KC, Myint T, Raymond-Guillen L, et al. Improvement in diagnosis of histoplasma meningitis by combined testing for histoplasma antigen and immunoglobulin G and immunoglobulin M anti-histoplasma antibody in cerebrospinal fluid. Clin Infect Dis. 2017;66:89–94.
pmcid: 5850023 doi: 10.1093/cid/cix706
Saag MS. HIV Infection—screening, diagnosis, and treatment. Reply. N Engl J Med. 2021;385:1344.
pubmed: 34587400
Wheat LJ, Joseph Wheat L, Freifeld AG, et al. Clinical Practice Guidelines for the Management of Patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007;45:807–25.
pubmed: 17806045 doi: 10.1086/521259
Ryom L, De Miguel R, Cotter AG, et al. Major revision version 11.0 of the European AIDS clinical society guidelines 2021. HIV Med. 2022. https://doi.org/10.1111/hiv.13268 .
doi: 10.1111/hiv.13268 pubmed: 35521975 pmcid: 9545286
Staffolani S, Riccardi N, Farina C, et al. Acute histoplasmosis in travelers: a retrospective study in an Italian referral center for tropical diseases. Pathog Glob Health. 2020;114:40–5.
pubmed: 31959091 pmcid: 7144294 doi: 10.1080/20477724.2020.1716517
Delfino E, Di Biagio A, Chandrapatham K, et al. Disseminated histoplasmosis with mucocutaneous immune reconstitution inflammatory syndrome in an HIV-infected patient. AIDS Res Hum Retroviruses. 2015;31:274–5.
pubmed: 25723353 doi: 10.1089/aid.2014.0329
Visonà A, Danieli D, Dante S, et al. Bilateral nodular pulmonary histoplasmosis: cytohistological correlation. Pathologica. 1991;83:197–200.
pubmed: 1720889
Bartoloni A, et al. Progressive disseminated histoplasmosis (PDH) in an art naïve migrant with advanced infection. Trop Med Int Health. 2011;16:163–4.
Papalini C, Belfiori B, Martino G, et al. An Italian Case of Disseminated Histoplasmosis Associated with HIV. Case Rep Infect Dis. 2019;2019:7403878.
pubmed: 31827952 pmcid: 6885199
Amadori F, Doria R, Gemignani G, et al. Histoplasmosis: the multiple sides of an uncommon disease. Infez Med. 2015;23:61–8.
pubmed: 25819054
Sotgiu G, Mantovani A, Mazzoni A. Histoplasmosis in Europe. Mycopathol Mycol Appl. 1970;40(1–2):53–74.
doi: 10.1007/BF02051484
Galetta D, Pelosi G, Nebuloni M, et al. Challenging diagnosis of an unusual solitary pulmonary nodule. Thorac Cardiovasc Surg. 2007;55:123–5.
pubmed: 17377868 doi: 10.1055/s-2006-924407
Romano C, Castelli A, Laurini L, et al. Case report. Primary cutaneous histoplasmosis in an immunosuppressed patient. Mycoses. 2000;43:151–4.
pubmed: 10907346 doi: 10.1046/j.1439-0507.2000.00563.x
Righi E, Lugano M, Assi M, et al. Histoplasmosis in a lung transplant recipient from a nonendemic area. Transpl Int. 2014;27:e99-101.
pubmed: 24861869 doi: 10.1111/tri.12365
Grancini A, Colosimo M, Mapelli C, et al. A case of Histoplasma capsulatum endophthalmitis diagnosed in Italy. Travel Med Infect Dis. 2013;11:256–8.
pubmed: 22999789 doi: 10.1016/j.tmaid.2012.09.001
Lio S, Cibin M, Marcello R, et al. Adrenal bilateral incidentaloma by reactivated histoplasmosis. J Endocrinol Invest. 2000;23:476–9.
pubmed: 11005274 doi: 10.1007/BF03343759
Nasta P, Donisi A, Cattane A, Chiodera A, Casari S. Acute histoplasmosis in spelunkers returning from Mato Grosso. Peru J Trav Med. 1997;4:176–8.
doi: 10.1111/j.1708-8305.1997.tb00815.x
Antinori S, Ridolfo AL, Casalini G, Giacomelli A. Endemic mycoses: geographical distribution is still a work in progress. Lancet Infect Dis. 2022;22:451.
pubmed: 35338871 doi: 10.1016/S1473-3099(22)00131-1
Molina-Morant D, Sánchez-Montalvá A, Salvador F, et al. Imported endemic mycoses in Spain: evolution of hospitalized cases, clinical characteristics and correlation with migratory movements, 1997–2014. PLoS Negl Trop Dis. 2018;12:e0006245.
pubmed: 29447170 pmcid: 5831632 doi: 10.1371/journal.pntd.0006245
Rivasi F, Casali B, Nanetti A, et al. Histoplasma capsulatum var. capsulatum occurring in an HIV-positive Ghanaian immigrant to Italy. Identification of H. capsulatum DNA by PCR from paraffin sample. APMIS. 2001;109:721–5.
pubmed: 11900050 doi: 10.1034/j.1600-0463.2001.d01-138.x
Miller R, Assi M. AST Infectious Diseases Community of Practice. Endemic fungal infections in solid organ transplant recipients-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019;33:e13553.
doi: 10.1111/ctr.13553
Sotgiu G, Mazzoni A, Mantovani A, Ajello L, Palmer J. Histoplasma capsulatum: occurrence in soil from the Emilia Romagna region of Italy. Science. 1965;147:624–6.
pubmed: 14241413 doi: 10.1126/science.147.3658.624.a
Mantovani A, Mazzoni A, Ajello L. Histoplasmosis in Italy Isolation of Histoplasma capsulatum from dogs in the province of Bologna. Sabouraudia. 1968;6:163–4.
pubmed: 5647148 doi: 10.1080/00362176885190291
Reginato A, Giannuzzi P, Ricciardi M, et al. Extradural spinal cord lesion in a dog: first case study of canine neurological histoplasmosis in Italy. Vet Microbiol. 2014;170:451–5.
pubmed: 24646600 doi: 10.1016/j.vetmic.2014.02.024
Corbelli G, Mazzoni A, Allegri L. Two additional cases of histoplasmosis as observed in Bologna Medical Clinic. Minerva Med. 1957;48:3823–36.
pubmed: 13503866
Zavoli G. Istoplasmosi oro-faringea. Arch Ital Otol. 1957;68:374.
Allegri L, Bottiglioni E. Nuova segnalazione di un caso di istoplasmosi polmonare autoctona. Mal Infez. 1958;4:135–7.
Costa A, Biressi PC, Della Beffa A, Solero C. Il primo caso clinico di istoplasmosi osservato in Piemonte. Giorn Accad Med. 1959;122:53–63.
Salfelder K, Reyes de Liscano T, Romanovich J, Moncador F. Uber einen fall von lungenhistoplasmom mit möglicher infektion in Italien. Mycosen. 1963;6:29–34.
doi: 10.1111/j.1439-0507.1963.tb02321.x
Papa B, Del Genio A. Su un caso di istoplasmosi a manifestazione cutanea. Arch Chir. 1965;2:257–158.
Mesolella C, Amorelli A. On a case of laryngeal histoplasmosis. Arch Ital Laringol. 1966;74:273–93.
pubmed: 5990427
Pellegrino A. Considerazioni clinico-epidemiologiche su un caso sporadico di istoplasmosi polmonare. Giorn It Mal Inf Par. 1977;29:318–9.
Zanini R, De Longis P, De Stefano G, Soscia F, Mascioli G, Perroni L. Osservazioni cliniche su un caso di istoplasmosi muco-cutanea. Giorn It Mal Inf Par. 1987;39:968–9.
Masini T, Ghidoni P, Riviera L. Mycoses in immunocompromised patients. An histopathologic study of 61 cases. Boll Ist Sieroter Milan. 1988;67:232–40.
pubmed: 3242562
Vaj P, Dragogna T, Milani R, et al. Pulmonary histoplasmosis. Presentation of a case. Radiol Med. 1989;78:393–5.
pubmed: 2595031
Tinelli M, Michelone G, Cavanna C. Recurrent Histoplasma capsulatum pneumonia: a case report. Microbiologica. 1992;15:89–93.
pubmed: 1556966
Biglino A, De Rosa G, Lipani F. Upper lobe infiltrate with cough, fever, fatigue. Eur Respir J. 1992;5:1021–2.
pubmed: 1426193 doi: 10.1183/09031936.93.05081021
Gori S, Scasso A, Paladini A. Histoplasmosis due to Histoplasma capsulatum in an Italian HIV positive patient returning from the Americas. J Mycol Méd. 1993;4:239–41.
Manfredi R, Mazzoni A, Nanetti A, et al. Histoplasmosis capsulati and duboisii in Europe: the impact of the HIV pandemic, travel and immigration. Eur J Epidemiol. 1994;10:675–81.
pubmed: 7672046 doi: 10.1007/BF01719280
Gargiulo M, Crispo C, Conte M, Forte G, Gnarini N, Sangiovanni V, Chirianni A, Progressive disseminated histoplasmosis in black male subject from Ivory Coast. Abstract 308. In: 5th European conference on clinical aspects and treatment of HIV-infection, Copenhagen; 1995
Conte A, De Longis P, Bordi E, De Mori P, Grillo LR. Istoplasmosi disseminata in un paziente con infezione da HIV. Giorn It AIDS. 1996;7:55–8.
Vullo V, Mastroianni CM, Ferone U, et al. Central nervous system involvement as a relapse of disseminated histoplasmosis in an Italian AIDS patient. J Infect. 1997;35:83–4.
pubmed: 9279732 doi: 10.1016/S0163-4453(97)91169-5
Antinori S, Galimberti L, Bonaccorso C, et al. A case of fatal disseminated histoplasmosis of autochthonous origin in an Italian AIDS patient. Eur J Clin Microbiol Infect Dis. 1997;16:545–6.
pubmed: 9272394 doi: 10.1007/BF01708242
Angius AG, Viviani MA, Muratori S, et al. Disseminated histoplasmosis presenting with cutaneous lesions in a patient with acquired immunodeficiency syndrome. J Eur Acad Dermatol Venereol. 1998;10:182–5.
pubmed: 9553921 doi: 10.1111/j.1468-3083.1998.tb00724.x
Pometta R, Trovato C, Viviani MA, et al. Chronic pulmonary histoplasmosis in a patient with a recent history of tuberculosis and persistent round lung lesions. Eur J Clin Microbiol Infect Dis. 1999;18:229–31.
pubmed: 10357063 doi: 10.1007/s100960050267
Faggi E, Tortoli E, Bartoloni A, et al. Late diagnosis of histoplasmosis in a Brazilian patient with acquired immunodeficiency syndrome. Clin Microbiol Infect. 2001;7:48–9.
pubmed: 11284949 doi: 10.1046/j.1469-0691.2001.00198.x
D’Antuono A, Andalò F, Raone B. Cutaneous lesions of disseminated histoplasmosis in a HIV positive patient. Ann Ital Dermatol Allergol Clin Sper. 2000;54(1):33–5.
Antinori S, Ridolfo AL, Corbellino M, et al. Disseminated histoplasmosis in patients with AIDS. 2 case reports. Recenti Prog Med. 2000;91:362–4.
pubmed: 10932920
Mignogna MD, Fedele S, Lo Russo L, et al. A case of oral localized histoplasmosis in an immunocompetent patient. Eur J Clin Microbiol Infect Dis. 2001;20:753–5.
pubmed: 11757982 doi: 10.1007/s100960100592
Rizzi EB, Schininà V, Bellussi A, et al. Pulmonary mycosis in AIDS. Eur J Radiol. 2001;37:42–6.
pubmed: 11274838 doi: 10.1016/S0720-048X(00)00223-0
Calza L, Manfredi R, Donzelli C, et al. Disseminated histoplasmosis with atypical cutaneous lesions in an Italian HIV-infected patient: another autochtonous case. HIV Med. 2003;4:145–8.
pubmed: 12702136 doi: 10.1046/j.1468-1293.2003.00144.x
Lo Cascio G, Ligozzi M, Maccacaro L, et al. Diagnostic aspects of cutaneous lesions due to Histoplasma capsulatum in African AIDS patients in nonendemic areas. Eur J Clin Microbiol Infect Dis. 2003;22:637–8.
pubmed: 14508658 doi: 10.1007/s10096-003-1010-7
Faggian F, Lanzafame M, Lattuada E, et al. Histoplasmosis in two human immunodeficiency virus-positive immigrants to Italy: clinical features and management in the highly active antiretroviral therapy era. South Med J. 2004;97:398–400.
pubmed: 15108837 doi: 10.1097/01.SMJ.0000084290.81423.21
Garavelli PL, Rosa F, Brustia D, et al. Disseminated histoplasmosis in a HIV seropositive patient with Kaposi sarcoma. Recenti Prog Med. 2005;96:492.
pubmed: 16491772
Inojosa W, Rossi MC, Laurino L, et al. Progressive disseminated histoplasmosis among human immunodeficiency virus-infected patients from West-Africa: report of four imported cases in Italy. Infez Med. 2011;19:49–55.
pubmed: 21471748
Fortuna G, Mignogna MD. Oral histoplasmosis of a healthy man in a non-endemic area. Infection. 2011;39:497–8.
pubmed: 21735110 doi: 10.1007/s15010-011-0147-z
Scarlata F, Imburgia C, Trizzino M, et al. Leprosy-like cutaneous presentation of Histoplasma capsulatum infection in an African HIV+ patient. Infez Med. 2012;20:211–3.
pubmed: 22992563
Ardizzoni A, Baschieri MC, Manca L, et al. The mycoarray as an aid for the diagnosis of an imported case of histoplasmosis in an Italian traveler returning from Brazil. J Travel Med. 2013;20:336–9.
pubmed: 23992579 doi: 10.1111/jtm.12060
Bonsignore A, Orcioni GF, Barranco R, et al. Fatal disseminated histoplasmosis presenting as FUO in an immunocompetent Italian host. Leg Med. 2017;25:66–70.
doi: 10.1016/j.legalmed.2017.01.008
Asperges E, Cavanna C, Mollaschi EMG. A case report of disseminated histoplasmosis in AIDS diagnosed through peripheral blood smear. Curr HIV Res. 2021;19(5):457–9.
pubmed: 34109913 doi: 10.2174/1570162X19666210607120404

Auteurs

Verena Zerbato (V)

Infectious Diseases Unit, Trieste University Hospital (ASUGI), Piazza dell'Ospitale 1, 34125, Trieste, Italy.

Stefano Di Bella (S)

Clinical Department of Medical, Surgical and Health Sciences, Trieste University, 34149, Trieste, Italy. stefano932@gmail.com.

Riccardo Pol (R)

Infectious Diseases Unit, Trieste University Hospital (ASUGI), Piazza dell'Ospitale 1, 34125, Trieste, Italy.

Francesco D'Aleo (F)

Microbiology and Virology Unit, Great Metropolitan Hospital "Bianchi Melacrino Morelli", 89124, Reggio Calabria, Italy.

Andrea Angheben (A)

Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore - Don Calabria Hospital, 37024 Negrar di Valpolicella, Verona, Italy.

Claudio Farina (C)

Microbiology and Virology Laboratory, ASST "Papa Giovanni XXIII", 24127, Bergamo, Italy.

Marco Conte (M)

Microbiology and Virology Unit, Great Metropolitan Hospital "Bianchi Melacrino Morelli", 89124, Reggio Calabria, Italy.

Francesco Luzzaro (F)

Clinical Microbiology and Virology Unit, "A. Manzoni" Hospital, 23900, Lecco, Italy.

Roberto Luzzati (R)

Clinical Department of Medical, Surgical and Health Sciences, Trieste University, 34149, Trieste, Italy.

Luigi Principe (L)

Clinical Pathology and Microbiology Unit, "S. Giovanni di Dio" Hospital, 88900, Crotone, Italy.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH