Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis.
CP: Developmental biology
CP: Immunology
adaptative immunity
aging
development
early lymphoid progenitors
human lymphopoiesis
lymphoid development architecture
multi-lymphoid progenitors
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
27 06 2023
27 06 2023
Historique:
received:
16
02
2023
revised:
13
04
2023
accepted:
22
05
2023
medline:
4
10
2023
pubmed:
9
6
2023
entrez:
9
6
2023
Statut:
ppublish
Résumé
Changes in lymphocyte production patterns occurring across human ontogeny remain poorly defined. In this study, we demonstrate that human lymphopoiesis is supported by three waves of embryonic, fetal, and postnatal multi-lymphoid progenitors (MLPs) differing in CD7 and CD10 expression and their output of CD127
Identifiants
pubmed: 37294633
pii: S2211-1247(23)00629-0
doi: 10.1016/j.celrep.2023.112618
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112618Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.