Sequence variants affecting voice pitch in humans.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
09 06 2023
Historique:
medline: 12 6 2023
pubmed: 9 6 2023
entrez: 9 6 2023
Statut: ppublish

Résumé

The genetic basis of the human vocal system is largely unknown, as are the sequence variants that give rise to individual differences in voice and speech. Here, we couple data on diversity in the sequence of the genome with voice and vowel acoustics in speech recordings from 12,901 Icelanders. We show how voice pitch and vowel acoustics vary across the life span and correlate with anthropometric, physiological, and cognitive traits. We found that voice pitch and vowel acoustics have a heritable component and discovered correlated common variants in

Identifiants

pubmed: 37294764
doi: 10.1126/sciadv.abq2969
pmc: PMC10256171
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabq2969

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Auteurs

Rosa S Gisladottir (RS)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.
Department of Icelandic and Comparative Cultural Studies, University of Iceland, Saemundargata 2, 102 Reykjavik, Iceland.

Agnar Helgason (A)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.
Department of Anthropology, University of Iceland, Saemundargata 10, 102 Reykjavik, Iceland.

Bjarni V Halldorsson (BV)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.
Department of Engineering, Reykjavik University, Menntavegur 1, 101 Reykjavik, Iceland.

Hannes Helgason (H)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Michal Borsky (M)

Department of Engineering, Reykjavik University, Menntavegur 1, 101 Reykjavik, Iceland.

Yu-Ren Chien (YR)

Department of Engineering, Reykjavik University, Menntavegur 1, 101 Reykjavik, Iceland.

Jon Gudnason (J)

Department of Engineering, Reykjavik University, Menntavegur 1, 101 Reykjavik, Iceland.

Sigurjon A Gudjonsson (SA)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Scott Moisik (S)

Division of Linguistics and Multilingual Studies, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.

Dan Dediu (D)

Department of Catalan Philology and General Linguistics, University of Barcelona, Gran Via 585, Barcelona 08007, Spain.
University of Barcelona Institute for Complex Systems (UBICS), Martí Franquès 1, Barcelona 08028, Spain.
Catalan Institute for Research and Advanced Studies (ICREA), Passeig Lluís Companys 23, Barcelona 08010, Spain.

Gudmar Thorleifsson (G)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Vinicius Tragante (V)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Mariana Bustamante (M)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Gudrun A Jonsdottir (GA)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Lilja Stefansdottir (L)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Gudrun Rutsdottir (G)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Sigurdur H Magnusson (SH)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Marteinn Hardarson (M)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Egil Ferkingstad (E)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Gisli H Halldorsson (GH)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.
School of Engineering and Natural Sciences, University of Iceland, Dunhagi 5, 107 Reykjavik, Iceland.

Solvi Rognvaldsson (S)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Astros Skuladottir (A)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Erna V Ivarsdottir (EV)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Gudmundur Norddahl (G)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Gudmundur Thorgeirsson (G)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.

Ingileif Jonsdottir (I)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.

Magnus O Ulfarsson (MO)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.
School of Engineering and Natural Sciences, University of Iceland, Dunhagi 5, 107 Reykjavik, Iceland.

Hilma Holm (H)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Hreinn Stefansson (H)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Unnur Thorsteinsdottir (U)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.

Daniel F Gudbjartsson (DF)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.
School of Engineering and Natural Sciences, University of Iceland, Dunhagi 5, 107 Reykjavik, Iceland.

Patrick Sulem (P)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

Kari Stefansson (K)

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.

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