Causal evidence for the processing of bodily self in the anterior precuneus.

Humans Parietal Lobe / diagnostic imaging Brain Brain Mapping / methods Magnetic Resonance Imaging / methods Neural Pathways
body schema brain network connectivity consciousness corticocortical evoked potential derealization dissociation fall float

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
16 08 2023
Historique:
received: 09 11 2022
revised: 05 03 2023
accepted: 14 05 2023
medline: 21 8 2023
pubmed: 10 6 2023
entrez: 9 6 2023
Statut: ppublish

Résumé

To probe the causal importance of the human posteromedial cortex (PMC) in processing the sense of self, we studied a rare cohort of nine patients with electrodes implanted bilaterally in the precuneus, posterior cingulate, and retrosplenial regions with a combination of neuroimaging, intracranial recordings, and direct cortical stimulations. In all participants, the stimulation of specific sites within the anterior precuneus (aPCu) caused dissociative changes in physical and spatial domains. Using single-pulse electrical stimulations and neuroimaging, we present effective and resting-state connectivity of aPCu hot zone with the rest of the brain and show that they are located outside the boundaries of the default mode network (DMN) but connected reciprocally with it. We propose that the function of this subregion of the PMC is integral to a range of cognitive processes that require the self's physical point of reference, given its location within a spatial environment.

Identifiants

DOI: 10.1016/j.neuron.2023.05.013 PMID: 37295420
pubmed: 37295420
pii: S0896-6273(23)00386-0
doi: 10.1016/j.neuron.2023.05.013
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2502-2512.e4

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Dian Lyu (D)

Laboratory of Behavioral and Cognitive Neuroscience, Stanford University School of Medicine, Stanford, CA, USA; Human Intracranial Cognitive Electrophysiology Program, Stanford University School of Medicine, Stanford, CA, USA; Departments of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: dl577@stanford.edu.

James Robert Stieger (JR)

Laboratory of Behavioral and Cognitive Neuroscience, Stanford University School of Medicine, Stanford, CA, USA; Human Intracranial Cognitive Electrophysiology Program, Stanford University School of Medicine, Stanford, CA, USA; Departments of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Cindy Xin (C)

Laboratory of Behavioral and Cognitive Neuroscience, Stanford University School of Medicine, Stanford, CA, USA; Human Intracranial Cognitive Electrophysiology Program, Stanford University School of Medicine, Stanford, CA, USA; Departments of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Eileen Ma (E)

Laboratory of Behavioral and Cognitive Neuroscience, Stanford University School of Medicine, Stanford, CA, USA; Human Intracranial Cognitive Electrophysiology Program, Stanford University School of Medicine, Stanford, CA, USA; Departments of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Zoe Lusk (Z)

Laboratory of Behavioral and Cognitive Neuroscience, Stanford University School of Medicine, Stanford, CA, USA; Human Intracranial Cognitive Electrophysiology Program, Stanford University School of Medicine, Stanford, CA, USA; Departments of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Mariel Kalkach Aparicio (MK)

Laboratory of Behavioral and Cognitive Neuroscience, Stanford University School of Medicine, Stanford, CA, USA.

Katherine Werbaneth (K)

Laboratory of Behavioral and Cognitive Neuroscience, Stanford University School of Medicine, Stanford, CA, USA; Human Intracranial Cognitive Electrophysiology Program, Stanford University School of Medicine, Stanford, CA, USA; Departments of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Claire Megan Perry (CM)

Laboratory of Behavioral and Cognitive Neuroscience, Stanford University School of Medicine, Stanford, CA, USA; Human Intracranial Cognitive Electrophysiology Program, Stanford University School of Medicine, Stanford, CA, USA; Departments of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Karl Deisseroth (K)

Departments of Psychiatry, Stanford University School of Medicine, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.

Vivek Buch (V)

Human Intracranial Cognitive Electrophysiology Program, Stanford University School of Medicine, Stanford, CA, USA; Departments of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.

Josef Parvizi (J)

Laboratory of Behavioral and Cognitive Neuroscience, Stanford University School of Medicine, Stanford, CA, USA; Human Intracranial Cognitive Electrophysiology Program, Stanford University School of Medicine, Stanford, CA, USA; Departments of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA; Departments of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: jparvizi@stanford.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Causal evidence for the processing of bodily...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe pariétal › Causal evidence for the processing of bodily...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Causal evidence for the processing of bodily...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Causal evidence for the processing of bodily...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Causal evidence for the processing of bodily...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Causal evidence for the processing of bodily...