Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort.

Humans Aged Alzheimer Disease / drug therapy Longitudinal Studies Data Collection
early-onset Alzheimer's disease early-onset dementia mild cognitive impairment neuropharmacology neuropsychiatric symptoms psychotropic medications

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
11 2023
Historique:
revised: 15 05 2023
received: 23 02 2023
accepted: 17 05 2023
pmc-release: 09 12 2024
medline: 30 11 2023
pubmed: 10 6 2023
entrez: 9 6 2023
Statut: ppublish

Résumé

We examined neuropsychiatric symptoms (NPS) and psychotropic medication use in a large sample of individuals with early-onset Alzheimer's disease (EOAD; onset 40-64 years) at the midway point of data collection for the Longitudinal Early-onset Alzheimer's Disease Study (LEADS). Baseline NPS (Neuropsychiatric Inventory - Questionnaire; Geriatric Depression Scale) and psychotropic medication use from 282 participants enrolled in LEADS were compared across diagnostic groups - amyloid-positive EOAD (n = 212) and amyloid negative early-onset non-Alzheimer's disease (EOnonAD; n = 70). Affective behaviors were the most common NPS in EOAD at similar frequencies to EOnonAD. Tension and impulse control behaviors were more common in EOnonAD. A minority of participants were using psychotropic medications, and use was higher in EOnonAD. Overall NPS burden and psychotropic medication use were higher in EOnonAD than EOAD participants. Future research will investigate moderators and etiological drivers of NPS, and NPS differences in EOAD versus late-onset AD.

Identifiants

DOI: 10.1002/alz.13344 PMID: 37296082 PMC: PMC10709525
pubmed: 37296082
doi: 10.1002/alz.13344
pmc: PMC10709525
mid: NIHMS1904906
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

S42-S48

Subventions

Organisme : NIA NIH HHS
ID : P30 AG066444
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066515
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062421
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072980
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062422
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066462
Pays : United States
Organisme : NIA NIH HHS
ID : U01AG057195
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057739
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066506
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072979
Pays : United States
Organisme : NIA NIH HHS
ID : U24AG021886
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG057195
Pays : United States
Organisme : NIA NIH HHS
ID : R56AG057195
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010133
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG057195
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066511
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG072122
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072977
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062677
Pays : United States

Informations de copyright

© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

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Auteurs

Angelina J Polsinelli (AJ)

Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Ryan J Wonderlin (RJ)

Marian University College of Osteopathic Medicine, Indianapolis, Indiana, USA.

Dustin B Hammers (DB)

Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Alex Pena Garcia (AP)

Marian University College of Osteopathic Medicine, Indianapolis, Indiana, USA.

Ani Eloyan (A)

Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA.

Alexander Taurone (A)

Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA.

Maryanne Thangarajah (M)

Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA.

Laurel Beckett (L)

Department of Public Health Sciences, University of California - Davis, Davis, California, USA.

Sujuan Gao (S)

Department of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Sophia Wang (S)

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Kala Kirby (K)

Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Paige E Logan (PE)

Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Paul Aisen (P)

Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.

Jeffrey L Dage (JL)

Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Tatiana Foroud (T)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Percy Griffin (P)

Medical & Scientific Relations Division, Alzheimer's Association, Chicago, Illinois, USA.

Leonardo Iaccarino (L)

Department of Neurology, University of California - San Francisco, San Francisco, California, USA.

Joel H Kramer (JH)

Department of Neurology, University of California - San Francisco, San Francisco, California, USA.

Robert Koeppe (R)

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.

Walter A Kukull (WA)

Department of Epidemiology, University of Washington, Seattle, Washington, USA.

Renaud La Joie (R)

Department of Neurology, University of California - San Francisco, San Francisco, California, USA.

Nidhi S Mundada (NS)

Department of Neurology, University of California - San Francisco, San Francisco, California, USA.

Melissa E Murray (ME)

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.

Kelly Nudelman (K)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

David N Soleimani-Meigooni (DN)

Department of Neurology, University of California - San Francisco, San Francisco, California, USA.

Malia Rumbaugh (M)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Arthur W Toga (AW)

Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Los Angeles, California, USA.

Alexandra Touroutoglou (A)

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Prashanthi Vemuri (P)

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Alireza Atri (A)

Banner Sun Health Research Institute, Sun City, Arizona, USA.

Gregory S Day (GS)

Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.

Ranjan Duara (R)

Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami, Florida, USA.

Neill R Graff-Radford (NR)

Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.

Lawrence S Honig (LS)

Taub Institute and Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.

David T Jones (DT)

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

Joseph Masdeu (J)

Nantz National Alzheimer Center, Houston Methodist and Weill Cornell Medicine, Houston, Texas, USA.

Mario F Mendez (MF)

Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Kyle Womack (K)

Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.

Erik Musiek (E)

Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.

Chiadi U Onyike (CU)

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Meghan Riddle (M)

Department of Psychiatry, Alpert Medical School, Brown University, Providence, Rhode Island, USA.

Emily Rogalski (E)

Department of Psychiatry and Behavioral Sciences, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Steven Salloway (S)

Department of Psychiatry, Alpert Medical School, Brown University, Providence, Rhode Island, USA.

Sharon J Sha (SJ)

Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, California, USA.

Raymond S Turner (RS)

Department of Neurology, Georgetown University, Washington D.C., USA.

Thomas S Wingo (TS)

Department of Neurology and Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.

David A Wolk (DA)

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Maria C Carrillo (MC)

Medical & Scientific Relations Division, Alzheimer's Association, Chicago, Illinois, USA.

Bradford C Dickerson (BC)

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Gil D Rabinovici (GD)

Department of Neurology, University of California - San Francisco, San Francisco, California, USA.

Liana G Apostolova (LG)

Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana, USA.
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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