The Immune Response to SARS-CoV-2 Vaccine in a Cohort of Family Pediatricians from Southern Italy.
COVID-19
IFN-γ
SARS-CoV2 antibodies
T-cell
TNF-α
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
23 May 2023
23 May 2023
Historique:
received:
14
04
2023
revised:
18
05
2023
accepted:
19
05
2023
medline:
12
6
2023
pubmed:
10
6
2023
entrez:
10
6
2023
Statut:
epublish
Résumé
In Italy, from January 2021, the Ministry of Health indicated a vaccination plan against COVID for frail patients and physicians based on a three-dose scheme. However, conflicting results have been reported on which biomarkers permit immunization assessment. We used several laboratory approaches (i.e., antibodies serum levels, flow cytometry analysis, and cytokines release by stimulated cells) to investigate the immune response in a cohort of 53 family pediatricians (FPs) at different times after the vaccine. We observed that the BNT162b2-mRNA vaccine induced a significant increase of specific antibodies after the third (booster) dose; however, the antibody titer was not predictive of the risk of developing the infection in the six months following the booster dose. The antigen stimulation of PBMC cells from subjects vaccinated with the third booster jab induced the increase of the activated T cells (i.e., CD4
Identifiants
pubmed: 37296568
pii: cells12111447
doi: 10.3390/cells12111447
pmc: PMC10252549
pii:
doi:
Substances chimiques
COVID-19 Vaccines
0
BNT162 Vaccine
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of University and Research
ID : PRIN 2020, code 20209TB4AX
Organisme : University of Naples Federico II
ID : 2020 FRA LINEA B
Organisme : Regione Campania
ID : POR Campania FESR2014/2020 O.S. 1.3 AZ. 1.3.1 AVVISO DGR 504 del 10/11/2021 - CUP B63C22001270002
Organisme : Regione Campania
ID : CEINGE TASK-FORCE-2022 COVID19 CUP n. D63C22000570002
Organisme : Regione Campania
ID : POR Campania FESR 2014/2020, code SURF 21058BP000000020 CUP B63C22001210007
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