BRMS1 in Gliomas-An Expression Analysis.
behavior
glioblastoma
mRNA
metastasis
protein
suppressor
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
25 May 2023
25 May 2023
Historique:
received:
06
04
2023
revised:
17
05
2023
accepted:
23
05
2023
medline:
10
6
2023
pubmed:
10
6
2023
entrez:
10
6
2023
Statut:
epublish
Résumé
The metastatic suppressor BRMS1 interacts with critical steps of the metastatic cascade in many cancer entities. As gliomas rarely metastasize, BRMS1 has mainly been neglected in glioma research. However, its interaction partners, such as NFκB, VEGF, or MMPs, are old acquaintances in neurooncology. The steps regulated by BRMS1, such as invasion, migration, and apoptosis, are commonly dysregulated in gliomas. Therefore, BRMS1 shows potential as a regulator of glioma behavior. By bioinformatic analysis, in addition to our cohort of 118 specimens, we determined BRMS1 mRNA and protein expression as well as its correlation with the clinical course in astrocytomas IDH mutant, CNS WHO grade 2/3, and glioblastoma IDH wild-type, CNS WHO grade 4. Interestingly, we found BRMS1 protein expression to be significantly decreased in the aforementioned gliomas, while BRMS1 mRNA appeared to be overexpressed throughout. This dysregulation was independent of patients' characteristics or survival. The protein and mRNA expression differences cannot be finally explained at this stage. However, they suggest a post-transcriptional dysregulation that has been previously described in other cancer entities. Our analyses present the first data on BRMS1 expression in gliomas that can provide a starting point for further investigations.
Identifiants
pubmed: 37296870
pii: cancers15112907
doi: 10.3390/cancers15112907
pmc: PMC10252102
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : German National Academic Foundation
ID : none
Organisme : Elite Network of the State Bavaria
ID : none
Organisme : Graduate School of Life Sciences (GSLS) Würzburg
ID : none
Organisme : Open Access Publication Fund of the University of Würzburg
ID : none
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