Glioblastoma Metabolism: Insights and Therapeutic Strategies.
cancer stem cells
glioblastoma
metabolism
therapy
tumorigenic processes
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 May 2023
23 May 2023
Historique:
received:
06
04
2023
revised:
10
05
2023
accepted:
18
05
2023
medline:
12
6
2023
pubmed:
10
6
2023
entrez:
10
6
2023
Statut:
epublish
Résumé
Tumor metabolism is emerging as a potential target for cancer therapies. This new approach holds particular promise for the treatment of glioblastoma, a highly lethal brain tumor that is resistant to conventional treatments, for which improving therapeutic strategies is a major challenge. The presence of glioma stem cells is a critical factor in therapy resistance, thus making it essential to eliminate these cells for the long-term survival of cancer patients. Recent advancements in our understanding of cancer metabolism have shown that glioblastoma metabolism is highly heterogeneous, and that cancer stem cells exhibit specific metabolic traits that support their unique functionality. The objective of this review is to examine the metabolic changes in glioblastoma and investigate the role of specific metabolic processes in tumorigenesis, as well as associated therapeutic approaches, with a particular focus on glioma stem cell populations.
Identifiants
pubmed: 37298093
pii: ijms24119137
doi: 10.3390/ijms24119137
pmc: PMC10252397
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Strasbourg
ID : ANR-10-IDEX-0002
Organisme : University of Strasbourg
ID : ANR-20-SFRI-0012
Organisme : Ministry of Education, Research and Innovation France
ID : xxxxx
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