MiR-182-5p Is Upregulated in Hepatic Tissues from a Diet-Induced NAFLD/NASH/HCC C57BL/6J Mouse Model and Modulates Cyld and Foxo1 Expression.
Cyld
Foxo1
HCC
NAFLD
NASH
biomarkers
miR-182-5p
therapeutic target
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 May 2023
25 May 2023
Historique:
received:
31
03
2023
revised:
15
05
2023
accepted:
23
05
2023
medline:
12
6
2023
pubmed:
10
6
2023
entrez:
10
6
2023
Statut:
epublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) is considered a relevant liver chronic disease. Variable percentages of NAFLD cases progress from steatosis to steatohepatitis (NASH), cirrhosis and, eventually, hepatocellular carcinoma (HCC). In this study, we aimed to deepen our understanding of expression levels and functional relationships between miR-182-5p and Cyld-Foxo1 in hepatic tissues from C57BL/6J mouse models of diet-induced NAFL/NASH/HCC progression. A miR-182-5p increase was detected early in livers as NAFLD damage progressed, and in tumors compared to peritumor normal tissues. An in vitro assay on HepG2 cells confirmed
Identifiants
pubmed: 37298191
pii: ijms24119239
doi: 10.3390/ijms24119239
pmc: PMC10252350
pii:
doi:
Substances chimiques
MicroRNAs
0
Mirn182 microRNA, human
0
Foxo1 protein, mouse
0
Forkhead Box Protein O1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : DISCAB GRANT 2022
ID : 07_DG_2022_25
Organisme : DISCAB GRANT 2023
ID : 07_DG_2023_23
Références
Nat Struct Mol Biol. 2015 Mar;22(3):222-9
pubmed: 25686088
Immunol Rev. 2012 Mar;246(1):107-24
pubmed: 22435550
Curr Opin Gastroenterol. 2015 May;31(3):184-91
pubmed: 25850346
Cell Cycle. 2012 May 15;11(10):1918-28
pubmed: 22544329
Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G116-G126
pubmed: 31021172
Mol Cancer Ther. 2014 Jul;13(7):1729-39
pubmed: 24825857
Comput Math Methods Med. 2021 Sep 13;2021:8773423
pubmed: 34552661
Oncotarget. 2017 Nov 01;8(65):108810-108824
pubmed: 29312570
J Hepatol. 2012 Nov;57(5):995-1003
pubmed: 22728872
Lancet Gastroenterol Hepatol. 2022 Sep;7(9):851-861
pubmed: 35798021
Mol Clin Oncol. 2013 Mar;1(2):309-314
pubmed: 24649166
Oncol Rep. 2018 Dec;40(6):3705-3713
pubmed: 30542706
Biomed Eng Online. 2021 Feb 16;20(1):21
pubmed: 33593374
BMC Cancer. 2016 Jan 05;16:3
pubmed: 26728044
Onco Targets Ther. 2020 Sep 16;13:9159-9167
pubmed: 32982304
Nat Rev Gastroenterol Hepatol. 2019 Jul;16(7):411-428
pubmed: 31028350
World J Gastroenterol. 2016 Aug 7;22(29):6742-56
pubmed: 27547017
World J Gastroenterol. 2020 May 7;26(17):1993-2011
pubmed: 32536770
Nat Rev Gastroenterol Hepatol. 2011 Feb;8(2):108-18
pubmed: 21293511
Mol Syst Biol. 2012 Feb 14;8:570
pubmed: 22333974
J Gastroenterol Hepatol. 2016 Sep;31(9):1646-53
pubmed: 26875698
BMC Cancer. 2012 Jun 08;12:227
pubmed: 22681717
Int J Mol Sci. 2022 Sep 29;23(19):
pubmed: 36232799
J Exp Clin Cancer Res. 2015 Jun 28;34:67
pubmed: 26126858
Oncol Rep. 2017 Mar;37(3):1445-1450
pubmed: 28184924
Nutrition. 2020 Jul - Aug;75-76:110782
pubmed: 32268264
Oncol Lett. 2018 Jan;15(1):991-997
pubmed: 29422969
J Biomed Res. 2018 Sep 29;32(5):327-335
pubmed: 28550272
Hepatology. 2010 Nov;52(5):1836-46
pubmed: 21038418
Eur J Clin Invest. 2020 Apr;50(4):e13211
pubmed: 32017057
J Clin Invest. 2006 Nov;116(11):3042-9
pubmed: 17053834
Curr Drug Targets. 2015;16(4):284-94
pubmed: 25342597
Antioxid Redox Signal. 2011 Feb 15;14(4):593-605
pubmed: 20618067
Cancer Cell. 2012 Jun 12;21(6):738-50
pubmed: 22698400
Ann Transl Med. 2022 Jul;10(14):769
pubmed: 35965793
Toxicol Sci. 2017 Mar 1;156(1):208-216
pubmed: 28013219
Oncol Rep. 2018 Dec;40(6):3561-3572
pubmed: 30272296
Hepatology. 2012 Feb;55(2):609-21
pubmed: 21953681
Cell Biol Int. 2021 Dec;45(12):2510-2520
pubmed: 34459063
Gene. 2013 Sep 15;527(1):26-32
pubmed: 23791657
Tumour Biol. 2015 Sep;36(10):7439-47
pubmed: 25903466
Front Genet. 2022 Mar 03;13:842943
pubmed: 35309123
Cancer Lett. 2015 Jun 28;362(1):97-105
pubmed: 25813403
Front Oncol. 2022 Aug 01;12:912881
pubmed: 35978827
Clin Gastroenterol Hepatol. 2012 Dec;10(12):1342-1359.e2
pubmed: 23041539
Biomed Pharmacother. 2019 Dec;120:109497
pubmed: 31606623
Mol Carcinog. 2016 Apr;55(4):366-75
pubmed: 25663355
Cell Mol Life Sci. 2016 Jun;73(11-12):2165-76
pubmed: 27066894
Nature. 2008 Sep 4;455(7209):58-63
pubmed: 18668040
Jpn J Clin Oncol. 2015 Aug;45(8):738-44
pubmed: 25917358
J Hematol Oncol. 2018 Jan 24;11(1):12
pubmed: 29361949
Cell Death Differ. 2010 Jan;17(1):25-34
pubmed: 19373246
Curr Diab Rep. 2021 Feb 5;21(3):8
pubmed: 33544287
BMC Bioinformatics. 2015 Dec 10;16:408
pubmed: 26652480
Med Res Rev. 2016 Mar;36(2):342-59
pubmed: 26763122
Chin J Cancer Res. 2014 Feb;26(1):17-29
pubmed: 24653623
Mod Pathol. 2019 Jul;32(7):997-1007
pubmed: 30809000
Free Radic Biol Med. 2020 May 20;152:116-141
pubmed: 32156524
Sci Rep. 2020 Jul 23;10(1):12327
pubmed: 32704044
Front Genet. 2021 Mar 29;12:633756
pubmed: 33854524
EJIFCC. 2009 Jan 20;19(4):203-11
pubmed: 27683318
Oncotarget. 2017 Jun 21;8(32):53482-53494
pubmed: 28881825
Wiley Interdiscip Rev RNA. 2023 Jan;14(1):e1768
pubmed: 36437633
ACS Appl Mater Interfaces. 2020 Jan 29;12(4):4308-4322
pubmed: 31939276
Transl Res. 2015 Sep;166(3):304-14
pubmed: 26001595
Cancer Lett. 2022 Jan 28;525:146-157
pubmed: 34742871
BMC Cancer. 2014 Dec 03;14:909
pubmed: 25472505
Biochem Biophys Res Commun. 2020 Jun 11;526(4):889-897
pubmed: 32279994
Biochim Biophys Acta. 2011 Nov;1813(11):1938-45
pubmed: 21708191
J Clin Invest. 2012 Oct;122(10):3563-78
pubmed: 23006329
J Biosci. 2011 Aug;36(3):481-91
pubmed: 21799259
Mol Biol Rep. 2017 Oct;44(5):391-397
pubmed: 28840581
Aging Cell. 2013 Dec;12(6):950-4
pubmed: 23815295
Ann Hepatol. 2022 May 27;:100726
pubmed: 35636732
Gene Ther. 2011 Dec;18(12):1121-6
pubmed: 21633392
Aging (Albany NY). 2020 May 3;12(9):8352-8371
pubmed: 32364530
Oncotarget. 2017 Jan 3;8(1):1703-1713
pubmed: 27924058
Cell Oncol (Dordr). 2021 Apr;44(2):279-295
pubmed: 33034848
Liver Int. 2016 Mar;36(3):334-43
pubmed: 26189820
Cancer Lett. 2015 Jan 28;356(2 Pt B):809-18
pubmed: 25449782
Cancers (Basel). 2020 Jul 24;12(8):
pubmed: 32722292