Investigating the Contribution of Major Drug-Metabolising Enzymes to Possum-Specific Fertility Control.
Trichosurus vulpecula
brushtail possum
drug-metabolising enzymes (CYP3A and UGT2B)
fertility control
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 May 2023
29 May 2023
Historique:
received:
19
04
2023
revised:
15
05
2023
accepted:
24
05
2023
medline:
12
6
2023
pubmed:
10
6
2023
entrez:
10
6
2023
Statut:
epublish
Résumé
The potential to improve the effectiveness and efficiency of potential oestrogen-based oral contraceptives (fertility control) for possums was investigated by comparing the inhibitory potential of hepatic CYP3A and UGT2B catalytic activity using a selected compound library (CYP450 inhibitor-based compounds) in possums to that of three other species (mouse, avian, and human). The results showed higher CYP3A protein levels in possum liver microsomes compared to other test species (up to a 4-fold difference). Moreover, possum liver microsomes had significantly higher basal
Identifiants
pubmed: 37298375
pii: ijms24119424
doi: 10.3390/ijms24119424
pmc: PMC10253456
pii:
doi:
Substances chimiques
Cytochrome P-450 CYP3A
EC 1.14.14.1
Ketoconazole
R9400W927I
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Operational Solutions for Primary Industries
ID : PL.11511501.P.LM
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