Transcranial Electromagnetic Wave Treatment: A Fountain of Healthy Longevity?


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
02 Jun 2023
Historique:
received: 04 05 2023
revised: 29 05 2023
accepted: 30 05 2023
medline: 12 6 2023
pubmed: 10 6 2023
entrez: 10 6 2023
Statut: epublish

Résumé

Most diseases of older age have as their common denominator a dysfunctional immune system, wherein a low, chronic level of inflammation is present due to an imbalance of pro-inflammatory cytokines over anti-inflammatory cytokines that develops during aging ("inflamm-aging"). A gerotherapeutic that can restore the immune balance to that shared by young/middle-aged adults and many centenarians could reduce the risk of those age-related diseases and increase healthy longevity. In this perspectives paper, we discuss potential longevity interventions that are being evaluated and compare them to a novel gerotherapeutic currently being evaluated in humans-Transcranial Electromagnetic Wave Treatment (TEMT). TEMT is provided non-invasively and safety through a novel bioengineered medical device-the MemorEM-that allows for near complete mobility during in-home treatments. Daily TEMT to mild/moderate Alzheimer's Disease (AD) patients over a 2-month period rebalanced 11 of 12 cytokines in blood back to that of normal aged adults. A very similar TEMT-induced rebalancing of cytokines occurred in the CSF/brain for essentially all seven measurable cytokines. Overall inflammation in both blood and brain was dramatically reduced by TEMT over a 14-27 month period, as measured by C-Reactive Protein. In these same AD patients, a reversal of cognitive impairment was observed at 2 months into treatment, while cognitive decline was stopped over a 2½ year period of TEMT. Since most age-related diseases have the commonality of immune imbalance, it is reasonable to postulate that TEMT could rebalance the immune system in many age-related diseases as it appears to do in AD. We propose that TEMT has the potential to reduce the risk/severity of age-related diseases by rejuvenating the immune system to a younger age, resulting in reduced brain/body inflammation and a substantial increase in healthy longevity.

Identifiants

pubmed: 37298603
pii: ijms24119652
doi: 10.3390/ijms24119652
pmc: PMC10253502
pii:
doi:

Substances chimiques

Cytokines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NINDS NIH HHS
ID : #12129318
Pays : United States

Références

BMJ. 2018 Aug 15;362:k2562
pubmed: 30111634
Exp Gerontol. 2002 May;37(5):657-63
pubmed: 11909683
Front Neurol. 2022 May 20;13:793253
pubmed: 35669870
Bioelectromagnetics. 2006 Apr;27(3):188-96
pubmed: 16342197
Front Aging Neurosci. 2022 May 02;14:829049
pubmed: 35585867
Radiat Res. 2006 Aug;166(2):409-21
pubmed: 16881742
Curr Alzheimer Res. 2014 Jan;11(1):27-39
pubmed: 24251394
Aging Cell. 2013 Jun;12(3):525-30
pubmed: 23489470
Alzheimers Dement. 2020 Apr;16(4):641-650
pubmed: 31879235
Alzheimer Dis Assoc Disord. 2013 Oct-Dec;27(4):310-5
pubmed: 23314064
Annu Rev Pathol. 2010;5:99-118
pubmed: 20078217
J Med Genet. 2003 Apr;40(4):296-9
pubmed: 12676903
Neuroimmunomodulation. 2008;15(4-6):224-40
pubmed: 19047800
Exp Neurol. 2001 Jan;167(1):40-7
pubmed: 11161591
J Alzheimers Dis. 2009;17(1):115-23
pubmed: 19494436
Psychiatr Clin North Am. 2023 Mar;46(1):133-166
pubmed: 36740349
Rejuvenation Res. 2008 Feb;11(1):63-72
pubmed: 18160025
Immunol Cell Biol. 2020 Jan;98(1):28-41
pubmed: 31654430
Exp Gerontol. 2004 May;39(5):687-99
pubmed: 15130663
J Neurol Neurosurg Psychiatry. 2019 May;90(5):590-598
pubmed: 30630955
Curr Alzheimer Res. 2015;12(5):481-92
pubmed: 26017559
Radiat Res. 2003 Nov;160(5):600-5
pubmed: 14565821
J Alzheimers Dis. 2012;32(2):243-66
pubmed: 22810103
J Alzheimers Dis. 2016 May 30;53(3):753-71
pubmed: 27258417
Medicines (Basel). 2022 Aug 03;9(8):
pubmed: 36005647
Science. 2016 Jun 17;352(6292):1436-43
pubmed: 27127236
Front Immunol. 2021 Mar 16;12:644213
pubmed: 33796111
PLoS One. 2009;4(2):e4389
pubmed: 19194493
Front Pharmacol. 2022 Jan 27;12:728315
pubmed: 35153733
Front Pharmacol. 2022 Jun 02;13:877709
pubmed: 35721185
Age (Dordr). 2010 Dec;32(4):451-66
pubmed: 20508994
Am J Lifestyle Med. 2016 Jul 07;10(5):318-321
pubmed: 30202288
EBioMedicine. 2019 Sep;47:446-456
pubmed: 31542391
CNS Neurol Disord Drug Targets. 2010 Apr;9(2):192-6
pubmed: 20205641
Cell Stem Cell. 2022 Jun 2;29(6):990-1005.e10
pubmed: 35613617
Exp Gerontol. 2018 May;105:53-69
pubmed: 29408453
J Alzheimers Dis. 2010;19(1):191-210
pubmed: 20061638
PLoS One. 2014 Oct 02;9(9):e108318
pubmed: 25275372
PLoS One. 2022 Jan 31;17(1):e0262846
pubmed: 35100285
Front Public Health. 2018 Mar 26;6:85
pubmed: 29632855
EBioMedicine. 2019 Feb;40:554-563
pubmed: 30616998
Trends Neurosci. 2021 Nov;44(11):864-875
pubmed: 34312005
Immunol Lett. 2022 Mar;243:19-27
pubmed: 35108570
Shanghai Arch Psychiatry. 2018 Apr 25;30(2):84-92
pubmed: 29736128
Nat Aging. 2021 Jul;1:598-615
pubmed: 34888528
Zhonghua Yu Fang Yi Xue Za Zhi. 2016 Jul 6;50(7):605-10
pubmed: 27412836
J Transl Med. 2011 Jul 20;9:113
pubmed: 21774806
Curr Pharm Des. 2010;16(6):584-96
pubmed: 20388068
Neuropsychiatr Dis Treat. 2023 Mar 08;19:565-577
pubmed: 36919097
J Am Coll Cardiol. 2022 Mar 1;79(8):837-847
pubmed: 35210039
Aging Cell. 2018 Apr;17(2):
pubmed: 29383869
J Clin Endocrinol Metab. 2010 Oct;95(10):4748-55
pubmed: 20660034
PLoS One. 2014 May 01;9(5):e95346
pubmed: 24788826
J Gerontol A Biol Sci Med Sci. 2019 Oct 4;74(11):1709-1715
pubmed: 30590424
Front Immunol. 2018 Apr 09;9:586
pubmed: 29686666
Pathophysiology. 2009 Aug;16(2-3):157-77
pubmed: 19398310
Toxicology. 2007 Aug 16;238(1):23-33
pubmed: 17624651
Adv Exp Med Biol. 2021;1305:333-349
pubmed: 33834408
Nat Metab. 2021 Oct;3(10):1290-1301
pubmed: 34663974
Am J Med. 1999 May;106(5):506-12
pubmed: 10335721
J Gerontol A Biol Sci Med Sci. 2022 Apr 1;77(4):673-682
pubmed: 34671810
Cell Metab. 2018 Mar 6;27(3):667-676.e4
pubmed: 29514072
J Alzheimers Dis. 2019;71(1):57-82
pubmed: 31403948
Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2680-2689
pubmed: 28690188
Mech Ageing Dev. 2021 Dec;200:111591
pubmed: 34699859
Sci Rep. 2018 Feb 15;8(1):3101
pubmed: 29449599
Biomed Pharmacother. 2008 Apr-May;62(4):273-81
pubmed: 18424058
Sci Rep. 2017 Sep 7;7(1):10798
pubmed: 28883444
Hypertension. 2006 Jun;47(6):1183-8
pubmed: 16636195
Neurobiol Aging. 2019 Apr;76:125-132
pubmed: 30711675
J Alzheimers Dis. 2012;30(3):559-72
pubmed: 22430531
Indian J Biochem Biophys. 1999 Oct;36(5):325-9
pubmed: 10844983
Nat Aging. 2021 Oct;1(10):870-879
pubmed: 34841261
Exp Gerontol. 2014 Oct;58:256-68
pubmed: 25172625
Nat Aging. 2021 Sep;1(9):783-794
pubmed: 37117627
Exp Gerontol. 1999 Jan;34(1):47-57
pubmed: 10197727
Annu Rev Anim Biosci. 2015;3:283-303
pubmed: 25689319
Neurosci Lett. 2018 Feb 14;666:64-69
pubmed: 29273398
Mol Neurodegener. 2018 Oct 3;13(1):51
pubmed: 30285785
PLoS One. 2012;7(4):e35751
pubmed: 22558216
Metabolism. 2022 Aug;133:155223
pubmed: 35640743
ScientificWorldJournal. 2012;2012:756357
pubmed: 22566778
Age Ageing. 2022 Aug 2;51(8):
pubmed: 35932241
Neuroscience. 2011 Jun 30;185:135-49
pubmed: 21514369
Radiat Res. 2006 Jun;165(6):664-70
pubmed: 16802866
FEBS J. 2020 Jan;287(1):43-52
pubmed: 31529582
Genes Immun. 2002 Feb;3(1):30-3
pubmed: 11857058
Alzheimers Dement. 2015 Feb;11(2):216-25.e1
pubmed: 25022541
Neurodegener Dis. 2008;5(2):55-9
pubmed: 18182779
J Neurosci. 2006 Jul 26;26(30):7811-9
pubmed: 16870726
J Neurooncol. 2019 Jan;141(1):139-149
pubmed: 30421160
eNeuro. 2020 Jan 7;7(1):
pubmed: 31848209
Psychol Med. 2018 Jun;48(8):1381-1389
pubmed: 29108529
Behav Brain Res. 2013 Mar 1;240:197-201
pubmed: 23195115
J Affect Disord. 2022 Apr 1;302:302-312
pubmed: 35041869
Biochemistry. 2000 Sep 5;39(35):10831-9
pubmed: 10978169
Hum Mol Genet. 2014 Aug 15;23(16):4420-32
pubmed: 24688116
Biophys J. 2010 Dec 15;99(12):L97-9
pubmed: 21156125
Curr Med Chem. 2019;26(20):3719-3753
pubmed: 30306855
Cell Metab. 2016 Jun 14;23(6):1060-1065
pubmed: 27304507
J Neuroinflammation. 2018 Sep 24;15(1):276
pubmed: 30249283
Front Immunol. 2019 Mar 15;10:480
pubmed: 30930904
Mech Ageing Dev. 2021 Oct;199:111567
pubmed: 34517020

Auteurs

Gary Arendash (G)

NeuroEM Therapeutics, Inc., 501 E. Kennedy Blvd., Suite 650, Tampa, FL 33602, USA.

Chuanhai Cao (C)

Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA.
MegaNano Biotech, 3802 Spectrum Blvd., Suite 122, Tampa, FL 33612, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH