Advances in Understanding the Human Gut Microbiota and Its Implication in Pediatric Celiac Disease-A Narrative Review.
celiac disease
dysbiosis
gut microbiota
microbiota modulation
pediatric
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
27 May 2023
27 May 2023
Historique:
received:
06
05
2023
revised:
21
05
2023
accepted:
25
05
2023
medline:
12
6
2023
pubmed:
10
6
2023
entrez:
10
6
2023
Statut:
epublish
Résumé
Celiac disease (CD) is a multifactorial disorder, defined by a complex interplay of genetic and environmental factors. Both genetic predisposition and dietary exposure to gluten are essential factors in triggering CD. However, there is proof that their presence is necessary, but not sufficient, for disease development. Through gut microbiota modulation, several additional environmental factors have shown their potential role as co-factors in CD pathogenesis. The aim of this review is to illustrate the possible mechanisms that stand behind the gut microbiota's involvement in CD pathogenesis. Furthermore, we discuss microbiota manipulation's potential role as both a preventative and therapeutic option. The available literature provides evidence that even before CD onset, factors including cesarean birth and formula feeding, as well as intestinal infection exposure, amplify the risk of CD in genetically predisposed individuals, due to their influence on the intestinal microbiome composition. Active CD was associated with elevated levels of several Gram-negative bacterial genera, including
Identifiants
pubmed: 37299462
pii: nu15112499
doi: 10.3390/nu15112499
pmc: PMC10255898
pii:
doi:
Substances chimiques
Glutens
8002-80-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Pediatr Gastroenterol Nutr. 2022 Sep 1;75(3):369-386
pubmed: 35758521
Expert Rev Clin Immunol. 2020 Nov;16(11):1075-1092
pubmed: 33103934
Gut. 2015 Mar;64(3):406-17
pubmed: 24939571
Diabetes Metab Res Rev. 2016 Oct;32(7):700-709
pubmed: 26891226
Gut Pathog. 2022 Sep 8;14(1):37
pubmed: 36076257
N Engl J Med. 2014 Oct 2;371(14):1295-303
pubmed: 25271602
Am J Gastroenterol. 2019 Aug;114(8):1307-1314
pubmed: 31082869
Lancet. 2003 Jun 21;361(9375):2152-4
pubmed: 12826451
BMC Microbiol. 2011 Oct 04;11:219
pubmed: 21970810
Am J Gastroenterol. 2020 Apr;115(4):507-525
pubmed: 32022718
PLoS One. 2022 Jan 14;17(1):e0262108
pubmed: 35030192
Am J Gastroenterol. 2006 Oct;101(10):2333-40
pubmed: 17032199
Eur J Gastroenterol Hepatol. 2005 Jan;17(1):21-6
pubmed: 15647635
Ann Med. 2021 Dec;53(1):1797-1805
pubmed: 34647492
World J Gastroenterol. 2023 Apr 7;29(13):1994-2000
pubmed: 37155522
Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):
pubmed: 34253606
Nutrients. 2018 Feb 12;10(2):
pubmed: 29439526
J Gastroenterol Hepatol. 2021 Jan;36(1):39-40
pubmed: 33448512
Curr Issues Mol Biol. 2010;12(1):1-10
pubmed: 19478349
J Int Med Res. 2022 Feb;50(2):3000605221076923
pubmed: 35118887
Microbiome. 2020 Sep 11;8(1):130
pubmed: 32917289
Eur J Gastroenterol Hepatol. 2006 Jan;18(1):75-8
pubmed: 16357623
PLoS One. 2015 Mar 20;10(3):e0121776
pubmed: 25793717
Gastroenterology. 2020 Dec;159(6):2039-2051.e20
pubmed: 32791131
Mod Pathol. 2015 Jan;28 Suppl 1:S22-9
pubmed: 25560597
Front Immunol. 2023 Jan 19;14:1056101
pubmed: 36742312
Dig Dis Sci. 2015 Nov;60(11):3386-92
pubmed: 26134988
Yao Xue Xue Bao. 2016 Jun;51(6):843-52
pubmed: 29878736
Br Med J. 1954 Dec 4;2(4900):1318-21
pubmed: 13209109
Nutr Hosp. 2013 Mar-Apr;28(2):464-73
pubmed: 23822699
Clin Gastroenterol Hepatol. 2017 May;15(5):694-702.e5
pubmed: 27840181
Front Immunol. 2023 Feb 22;14:1106564
pubmed: 36911718
EBioMedicine. 2021 Apr;66:103293
pubmed: 33813134
Mucosal Immunol. 2015 Jan;8(1):152-60
pubmed: 24938744
Cureus. 2021 Jul 29;13(7):e16721
pubmed: 34513356
Microbes Environ. 2014;29(4):427-30
pubmed: 25283478
J Gastroenterol Hepatol. 2021 Feb;36(2):446-454
pubmed: 32666516
PLoS One. 2012;7(3):e33387
pubmed: 22432018
Scand J Gastroenterol. 2018 Apr;53(4):403-409
pubmed: 29504486
Cells. 2023 Apr 14;12(8):
pubmed: 37190067
Nature. 2018 Oct;562(7728):583-588
pubmed: 30356187
Life (Basel). 2023 Jan 21;13(2):
pubmed: 36836657
PLoS One. 2015 Jul 24;10(7):e0133804
pubmed: 26207384
World J Gastroenterol. 2018 Oct 21;24(39):4510-4516
pubmed: 30356965
Diabetes Care. 2014 Sep;37(9):e194-5
pubmed: 25147260
Br J Nutr. 2014 Jul 14;112(1):30-40
pubmed: 24774670
JAMA Pediatr. 2020 Nov 1;174(11):1041-1047
pubmed: 32986087
Microbiome. 2018 Aug 4;6(1):135
pubmed: 30077182
Klin Wochenschr. 1964 Aug 15;42:788-90
pubmed: 14297735
Inflamm Bowel Dis. 2013 Apr;19(5):934-41
pubmed: 23478804
Dig Dis Sci. 2022 Jan;67(1):216-223
pubmed: 33723701
Autoimmun Rev. 2020 Sep;19(9):102621
pubmed: 32693029
Gut. 2020 Aug;69(8):1416-1422
pubmed: 31744911
J Clin Invest. 1972 Jun;51(6):1602-5
pubmed: 5024049
Gut Microbes. 2018 Nov 2;9(6):551-558
pubmed: 29672211
Gastroenterology. 2018 Jan;154(1):154-167
pubmed: 28912020
Nutrients. 2016 Oct 22;8(10):
pubmed: 27782071
Microbiome. 2023 Jan 13;11(1):9
pubmed: 36639805
Aliment Pharmacol Ther. 2021 Jul;54(2):109-128
pubmed: 34115894
Front Immunol. 2018 Sep 10;9:2039
pubmed: 30250470
Aliment Pharmacol Ther. 2005 Apr 1;21(7):881-7
pubmed: 15801923
JPGN Rep. 2021 Oct 13;2(4):e127
pubmed: 37206457
Gut. 1993 Nov;34(11):1473-5
pubmed: 8244125
Diabetes Care. 2011 Jun;34(6):1301-5
pubmed: 21515839
Eur J Nutr. 2020 Feb;59(1):409-417
pubmed: 31734734
Biomedicines. 2022 Dec 02;10(12):
pubmed: 36551874
Nutrients. 2019 Aug 16;11(8):
pubmed: 31426299
Trends Genet. 2016 May;32(5):295-308
pubmed: 26972670
Appl Environ Microbiol. 2013 Sep;79(18):5472-9
pubmed: 23835180
JAMA. 2019 Aug 13;322(6):514-523
pubmed: 31408136
Clin Nutr. 2019 Jun;38(3):1373-1381
pubmed: 29960810
Nutrients. 2019 Oct 08;11(10):
pubmed: 31597349
Arch Dis Child. 1990 Aug;65(8):909-11
pubmed: 2205160
Arch Dis Child. 1979 Oct;54(10):783-6
pubmed: 507902
BMC Microbiol. 2010 Jun 17;10:175
pubmed: 20565734
J Nutr Biochem. 2016 Sep;35:30-36
pubmed: 27362974
N Engl J Med. 2014 Oct 2;371(14):1304-15
pubmed: 25271603
Front Endocrinol (Lausanne). 2017 Nov 23;8:315
pubmed: 29218028
Circulation. 2018 Nov 27;138(22):2486-2498
pubmed: 30571343
Cell Metab. 2019 Oct 1;30(4):800-823.e7
pubmed: 31523007
Am J Gastroenterol. 2019 Aug;114(8):1299-1306
pubmed: 31343439