Association of long-term exposure to ambient air pollution with retinal neurodegeneration: the prospective Alienor study.
Air pollution
Central nervous system (CNS)
Glaucoma
Neurodegeneration
Retina
Retinal nerve fiber layer (RNFL)
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
01 Sep 2023
01 Sep 2023
Historique:
received:
13
02
2023
revised:
23
05
2023
accepted:
07
06
2023
medline:
17
7
2023
pubmed:
11
6
2023
entrez:
10
6
2023
Statut:
ppublish
Résumé
Chronic exposure to air pollution may have adverse effects on neurodegenerative diseases. Glaucoma, the second leading cause of blindness worldwide, is a neurodegenerative disease of the optic nerve, characterized by progressive thinning of the retinal nerve fiber layer (RNFL). We investigated the relationship of air pollution exposure with longitudinal changes of RNFL thickness in the Alienor study, a population-based cohort of residents of Bordeaux, France, aged 75 years or more. Peripapillary RNFL thickness was measured using optical coherence tomography imaging every 2 years from 2009 to 2020. Measurements were acquired and reviewed by specially trained technicians to control quality. Air pollution exposure (particulate matter ≤2.5 μm (PM
Identifiants
pubmed: 37301495
pii: S0013-9351(23)01168-4
doi: 10.1016/j.envres.2023.116364
pii:
doi:
Substances chimiques
Nitrogen Dioxide
S7G510RUBH
Particulate Matter
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116364Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Cécile Delcourt : Consultant for Allergan, Bausch+Lomb, Laboratoires Théa and Novartis. Audrey Cougnard-Grégoire : Travel fees from Laboratoires Théa. Jean-François Korobelnik : Consultant pour Abbvie, Apellis, Bayer, Janssen, Nanoretina, Roche, Théa, Carl Zeiss Meditec. Membre du DSMB pour Alexion, Nonordisk. Marie-Noelle Delyfer: Consultant for AbbVie, Bayer, Horama, Horus Pharma, Novartis, Roche et Thea. Cédric Schweitzer: Consultant for Abbvie, Alcon, Glaukos, Nicox, Théa, Horus, Johnson & Johnson, Santen, Bausch & Lomb. Laure Gayraud, Marion Mortamais, Kees de Hoogh, Marie-Bénédicte Rougier, Karen Leffondré, Catherine Helmer, Danielle Vienneau, Claudine Berr : None.