Alaska Backcountry Expeditionary Hunting Promotes Sustained Muscle Protein Synthesis.
caloric balance
energy expenditure
musculoskeletal
physical activity
Journal
Wilderness & environmental medicine
ISSN: 1545-1534
Titre abrégé: Wilderness Environ Med
Pays: United States
ID NLM: 9505185
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
12
02
2023
revised:
02
05
2023
accepted:
05
05
2023
pmc-release:
01
09
2024
medline:
28
8
2023
pubmed:
11
6
2023
entrez:
10
6
2023
Statut:
ppublish
Résumé
We have previously described negative energy balance (ie, -9.7±3.4 MJ/d) and weight loss (Δ-1.5 ± 0.7 kg) influenced by high levels of energy expenditure (ie, 17.4±2.6 MJ/d) during remote expeditionary hunting in Alaska. Despite negative energy balance, participants retained skeletal muscle. The purpose of this pilot study was to measure skeletal muscle protein synthesis and examine molecular markers of skeletal muscle protein metabolism under similar conditions of physical and nutrient stress. The "virtual biopsy method" was used to evaluate integrated fractional synthetic rates (FSRs) of muscle protein from blood samples in 4 participants. Muscle biopsies were taken to measure molecular markers of muscle protein kinetics (ie, FSTL1, MEF2, MYOD1, B2M, and miR-1-3p, -206, -208b, 23a, and 499a) using real-time polymerase chain reaction. Our findings in 4 participants (2 females [28 and 62 y of age; 66.2 and 71.8 kg body weight; 25.5 and 26.7 kg/m Preservation of skeletal muscle under conditions of physical and nutrient stress seems to be supported by positive inflection of skeletal muscle FSR and molecular activation.
Identifiants
pubmed: 37301628
pii: S1080-6032(23)00093-5
doi: 10.1016/j.wem.2023.05.003
pmc: PMC10526753
mid: NIHMS1907656
pii:
doi:
Substances chimiques
Muscle Proteins
0
FSTL1 protein, human
158709-61-6
Follistatin-Related Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
341-345Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103395
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM130443
Pays : United States
Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
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