Localized immunomodulation technologies to enable cellular and organoid transplantation.

Localized immunomodulation technologies are rapidly emerging as a new modality with the potential to revolutionize transplantation of cells and organs. In the past decade, cell-based immunomodulation therapies saw clinical success in the treatment of cancer and autoimmune diseases. In this review, we describe recent advances in engineering solutions for the development of localized immunomodulation techniques focusing on cellular and organoid transplantation. We begin by describing cell transplantation and highlighting notable clinical successes, particularly in the areas of stem cell therapy, chimeric antigen receptor (CAR)-T cell therapy, and islet transplantation. Next, we detail recent preclinical studies centered on genome editing and biomaterials to enhance localized immunomodulation. We close by discussing future opportunities to improve clinical and commercial success using these approaches to facilitate long-term immunomodulation technologies.

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Déclaration de conflit d'intérêts

Declaration of interests The authors declare the following financial interests/personal relationships, which may be considered as potential competing interests: O.V. is cofounder of, holds equity in, and receives consulting payments from Sigilon Therapeutics, Pana Bio, and Avenge Bio; O.V. also receives compensation for consulting from Establishment Labs and Auregen BioTherapeutics SA.