Determinants of First-Ever Stroke Severity in West Africans: Evidence From the SIREN Study.
SIREN
West Africa
determinant
stroke severity
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
20 06 2023
20 06 2023
Historique:
medline:
21
6
2023
pubmed:
11
6
2023
entrez:
10
6
2023
Statut:
ppublish
Résumé
Background Baseline stroke severity is probably partly responsible for poor stroke outcomes in sub-Saharan Africa. However, there is a paucity of information on determinants of stroke severity among indigenous Africans. We sought to identify the factors associated with stroke severity among West Africans in the SIREN (Stroke Investigative Research and Educational Networks) study. Methods and Results Stroke was diagnosed clinically and confirmed with brain neuroimaging. Severe stroke was defined as a Stroke Levity Scale score of ≤5. A multivariate logistic regression model was constructed to identify factors associated with stroke severity at 95% CI and a nominal cutoff of 5% type 1 error. A total of 3660 stroke cases were included. Overall, 50.7%% had severe stroke, including 47.6% of all ischemic strokes and 56.1% of intracerebral hemorrhage. Factors independently associated with severe stroke were meat consumption (adjusted odds ratio [aOR], 1.97 [95% CI, 1.43-2.73]), low vegetable consumption (aOR, 2.45 [95% CI, 1.93-3.12]), and lesion volume, with an aOR of 1.67 (95% CI, 1.03-2.72) for lesion volume of 10 to 30 cm
Identifiants
pubmed: 37301737
doi: 10.1161/JAHA.122.027888
pmc: PMC10356032
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e027888Subventions
Organisme : NHGRI NIH HHS
ID : U24 HG009780
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG010273
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW012030
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS115944
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107900
Pays : United States
Organisme : NINDS NIH HHS
ID : R13 NS115395
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114045
Pays : United States
Organisme : NHGRI NIH HHS
ID : U54 HG007479
Pays : United States
Investigateurs
Oladimeji Adebayo
(O)
Onoja Akpa
(O)
Osahon J Asowata
(OJ)
Adekunle Fakunle
(A)
Fred S Sarfo
(FS)
Albert Akpalu
(A)
Kolawole Wahab
(K)
Reginald Obiako
(R)
Morenikeji Komolafe
(M)
Lukman Owolabi
(L)
Godwin O Osaigbovo
(GO)
Akinkunmi Paul Okekunle
(AP)
Taofiki Sunmonu
(T)
Hemant K Tiwari
(HK)
Carolyn Jenkins
(C)
Oyedunni Arulogun
(O)
Lambert Appiah
(L)
Joshua Akinyemi
(J)
Abiodun M Adeoye
(AM)
Godwin Ogbole
(G)
Joseph Yaria
(J)
Donna Arnett
(D)
Philip Adebayo
(P)
Benedict Calys-Tagoe
(B)
Okechukwu S Ogah
(OS)
Olayemi Balogun
(O)
Luqman Ogunjimi
(L)
Yaw Mensah
(Y)
Obiageli U Agbogu-Ike
(OU)
Rufus Akinyemi
(R)
Bruce Ovbiagele
(B)
Mayowa Owolabi
(M)
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