Preliminary Study of the Cancer Stem Cells' Biomarker CD147 in Leukoplakia: Dysplasia and Squamous Cell Carcinoma of Oral Epithelial Origin.
cancer stem cells
cd147
immunohistochemistry staining
oral cancers
oral leukoplakia
oscc
rt-qpcr
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
accepted:
09
05
2023
medline:
12
6
2023
pubmed:
12
6
2023
entrez:
12
6
2023
Statut:
epublish
Résumé
Objectives Cancer stem cells (CSCs) are responsible for initiating the process of carcinogenesis de novo, as well as through the transformation of oral potential malignant disorders (OPMDs) to oral squamous cell carcinoma (OSCC). The aim of our study was to detect the expression of stemness-type CSC marker CD147 in oral leukoplakias (OLs), the most common OPMD, and OSCCs as well. Materials and methods This study focuses on the semiquantitative immunohistochemical pattern of the expression of the CSC protein biomarker CD147 in paraffin-embedded samples of 20 OSCCs of different grades of differentiation and 30 cases of OLs without or with different grades of dysplasia, compared to the normal oral epithelium in terms of cells' stain positivity. Statistical analysis was performed through Statistical Package for Social Sciences (SPSS) version 25.0 (IBM SPSS Statistics, Armonk, NY) with Pearson chi-square test, and the significance level was set at 0.05 (p=0.05). In addition, the study clarified the expression of the respective gene of
Identifiants
pubmed: 37303447
doi: 10.7759/cureus.38807
pmc: PMC10256256
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e38807Informations de copyright
Copyright © 2023, Zisis et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Head Neck. 2014 Dec;36(12):1783-8
pubmed: 24488688
Future Oncol. 2014 Apr;10(5):735-48
pubmed: 24799055
J Oncol. 2021 Feb 13;2021:6663720
pubmed: 33854547
Biomed Res Int. 2014;2014:905680
pubmed: 24967412
Oncol Rep. 2007 Apr;17(4):731-5
pubmed: 17342307
Lab Invest. 2016 May;96(5):508-16
pubmed: 26927514
Eur J Cancer. 2000 Aug;36(13 Spec No):1621-30
pubmed: 10959048
J Oral Pathol Med. 2008 Mar;37(3):127-33
pubmed: 18251935
Oral Oncol. 2005 Mar;41(3):283-93
pubmed: 15743691
J Oral Maxillofac Surg. 2007 Sep;65(9):1725-33
pubmed: 17719389
Cancers (Basel). 2018 Sep 22;10(10):
pubmed: 30248985
Oral Oncol. 2020 Aug;107:104799
pubmed: 32446214
Stem Cell Res. 2013 May;10(3):477-88
pubmed: 23523931
Nature. 2001 May 17;411(6835):375-9
pubmed: 11357145
Clin Oral Investig. 2014 Jan;18(1):199-210
pubmed: 23430339
Oral Oncol. 2015 Jan;51(1):31-9
pubmed: 25456004
Oral Oncol. 2014 Dec;50(12):1144-8
pubmed: 25264224
Oral Oncol. 2011 Jun;47(6):510-6
pubmed: 21514878
Biomed Res Int. 2015;2015:242437
pubmed: 26779534
Microvasc Res. 2017 Jul;112:101-108
pubmed: 28344048
Oral Oncol. 2006 Nov;42(10):987-93
pubmed: 16731030
Biomed Res Int. 2020 Feb 20;2020:7638975
pubmed: 32149134
Oncotarget. 2015;6(12):9766-80
pubmed: 25825981
Oral Oncol. 2017 Dec;75:140-147
pubmed: 29224811
Cancer Res. 2012 Jan 1;72(1):365-74
pubmed: 22086849
J Oral Pathol Med. 2018 Sep;47(8):740-747
pubmed: 29791975
J Pathol. 2015 Nov;237(3):273-81
pubmed: 26174849
Nat Rev Mol Cell Biol. 2014 Dec;15(12):786-801
pubmed: 25415508
Genes Dev. 2000 Jan 15;14(2):163-76
pubmed: 10652271
Biomed Res Int. 2020 Jul 17;2020:8573793
pubmed: 32733958
Mol Cell Proteomics. 2013 Nov;12(11):3271-84
pubmed: 23903875
Med Oral Patol Oral Cir Bucal. 2020 Jan 1;25(1):e84-e88
pubmed: 31880285
J Hepatol. 2014 Oct;61(4):859-66
pubmed: 24801417
Oral Oncol. 2014 Jul;50(7):633-9
pubmed: 24835851
Cancer Epidemiol Biomarkers Prev. 2019 Jan;28(1):144-153
pubmed: 30315141
Integr Cancer Ther. 2015 Sep;14(5):484-90
pubmed: 26036622
Cancer Lett. 2010 Mar 28;289(2):151-60
pubmed: 19748175
Mol Cell Biochem. 2013 Jul;379(1-2):107-13
pubmed: 23716178
Med Oral Patol Oral Cir Bucal. 2015 Nov 01;20(6):e645-50
pubmed: 26449426
Med Oral Patol Oral Cir Bucal. 2013 Jan 01;18(1):e19-26
pubmed: 23085711
Clin Cancer Res. 2008 Jul 1;14(13):4085-95
pubmed: 18593985
Int J Cancer. 2011 Nov 15;129(10):2337-48
pubmed: 21225626