S. epidermidis
aryl hydrocarbon receptor
biofilms
indoles
inflammation
proteases
skin microbiome
skin type
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
14
11
2022
accepted:
04
05
2023
medline:
13
6
2023
pubmed:
12
6
2023
entrez:
12
6
2023
Statut:
epublish
Résumé
S For this purpose, a library of 12 strains originated from healthy skin (non-hyperseborrheic (NH) and hyperseborrheic (H) skin types) and disease skin (atopic (AD) skin type) was characterized at the genomic and phenotypic levels. Here we showed that strains from atopic lesional skin alter the epidermis structure of a 3D reconstructed skin model whereas strains from NH healthy skin do not. All strains from NH healthy skin induced AhR/OVOL1 path and produced high quantities of indole metabolites in co-culture with NHEK; especially indole-3-aldehyde (IAld) and indole-3-lactic acid (ILA); while AD strains did not induce AhR/OVOL1 path but its inhibitor STAT6 and produced the lowest levels of indoles as compared to the other strains. As a consequence, strains from AD skin altered the differentiation markers FLG and DSG1. The results presented here, on a library of 12 strains, showed that
Identifiants
pubmed: 37304256
doi: 10.3389/fimmu.2023.1098160
pmc: PMC10250813
doi:
Substances chimiques
Receptors, Aryl Hydrocarbon
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1098160Informations de copyright
Copyright © 2023 Landemaine, Da Costa, Fissier, Francis, Morand, Verbeke, Michel, Briandet, Sokol, Gueniche, Bernard, Chatel, Aguilar, Langella, Clavaud and Richard.
Déclaration de conflit d'intérêts
Authors LL, CC, CF, SM, AG, DB and LA were employed by the company L’Oréal Research and Innovation, Aulnay-sous-Bois. JV was employed by iMEAN, Toulouse, France. L’Oréal Research and Innovation, as funder, has been involved in the decision to submit the study for publication.
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