X-ray Diffraction of Water in Polyvinylpyrrolidone.

Povidone / chemistry Water / chemistry X-Ray Diffraction Polymers / chemistry Oxygen
EPSR modeling Kollidon X-ray diffraction amorphous structure pair distribution function polyvinylpyrrolidone

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
03 07 2023
Historique:
medline: 4 7 2023
pubmed: 12 6 2023
entrez: 12 6 2023
Statut: ppublish

Résumé

PVP is a hydrophilic polymer commonly used as an excipient in pharmaceutical formulations. Here we have performed time-resolved high-energy X-ray scattering experiments on pellets of PVP at different humidity conditions for 1-2 days. A two-phase exponential decay in water sorption is found with a peak in the differential pair distribution function at 2.85 Å, which is attributed to the average (hydrogen bonded) carbonyl oxygen-water oxygen distance. Additional scattering measurements on powders with fixed compositions ranging from 2 to 12.3 wt % H

Identifiants

DOI: 10.1021/acs.molpharmaceut.3c00265 PMID: 37306254
pubmed: 37306254
doi: 10.1021/acs.molpharmaceut.3c00265
doi:

Substances chimiques

Povidone FZ989GH94E
Water 059QF0KO0R
Polymers 0
Oxygen S88TT14065

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

3645-3652

Subventions

Organisme : NIGMS NIH HHS
ID : R44 GM117701
Pays : United States

Auteurs

C J Benmore (CJ)

X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439, USA.
ORCID: 0000-0001-7007-7749

S R Benmore (SR)

Materials Development, Inc., Arlington Heights, Illinois 60004, USA.

S K Wilke (SK)

X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439, USA.
Materials Development, Inc., Arlington Heights, Illinois 60004, USA.

V Menon (V)

Materials Development, Inc., Arlington Heights, Illinois 60004, USA.

S R Byrn (SR)

Improved Pharma, West Lafayette, Indiana 47906, USA.

J K R Weber (JKR)

X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439, USA.
Materials Development, Inc., Arlington Heights, Illinois 60004, USA.

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Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Polyvinyles › Povidone › X-ray Diffraction of Water in Polyvinylpyrrolidone.
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › X-ray Diffraction of Water in Polyvinylpyrrolidone.
questionsmedicales.fr › Phénomènes chimiques › Diffraction des rayons X › X-ray Diffraction of Water in Polyvinylpyrrolidone.
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › X-ray Diffraction of Water in Polyvinylpyrrolidone.
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › X-ray Diffraction of Water in Polyvinylpyrrolidone.