Biochemical Markers of Calcium and Bone Metabolism during and after Lactation in Ugandan Women with HIV on Universal Maternal Antiretroviral Therapy.


Journal

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: England
ID NLM: 8610640

Informations de publication

Date de publication:
09 2023
Historique:
revised: 05 06 2023
received: 10 03 2023
accepted: 08 06 2023
medline: 25 9 2023
pubmed: 12 6 2023
entrez: 12 6 2023
Statut: ppublish

Résumé

We reported accentuated lactational decreases in areal bone mineral density and only partial skeletal recovery after lactation in Ugandan women with HIV (WWH) initiated on tenofovir disoproxil fumarate-based antiretroviral therapy (TDF-based ART) during pregnancy compared to women without HIV (REF). WWH also had higher breast milk calcium in the first months of lactation. To investigate the mechanisms, we measured bone turnover markers (bone resorption: C-terminal telopeptide [CTX]; bone formation: procollagen type 1 N-terminal propeptide [P1NP], bone-specific and total alkaline phosphatase [BALP, TALP]), hormones (parathyroid hormone [PTH], intact fibroblast growth factor 23 [FGF23], 1,25-dihydroxyvitamin D [1,25(OH)

Identifiants

pubmed: 37306529
doi: 10.1002/jbmr.4866
doi:

Substances chimiques

Calcium SY7Q814VUP
Parathyroid Hormone 0
Vitamin D 1406-16-2
Tenofovir 99YXE507IL
Calcium, Dietary 0
Minerals 0
Phosphates 0
Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1296-1311

Subventions

Organisme : Medical Research Council
Pays : United Kingdom
Organisme : Medical Research Council
ID : U105960371
Pays : United Kingdom

Informations de copyright

© 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

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Auteurs

Florence Nabwire (F)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
MRC Nutrition and Bone Health Research Group, Cambridge, UK.
Formely based at the MRC Elsie Widdowson Laboratory, Cambridge, UK.

Matthew M Hamill (MM)

MRC Nutrition and Bone Health Research Group, Cambridge, UK.
Formely based at the MRC Elsie Widdowson Laboratory, Cambridge, UK.
Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Mary Glenn Fowler (MG)

Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Josaphat Byamugisha (J)

Makerere University, Kampala, Uganda.

Adeodata Kekitiinwa (A)

Baylor College of Medicine Children's Foundation - Uganda (Baylor-Uganda), Kampala, Uganda.

Ann Prentice (A)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
MRC Nutrition and Bone Health Research Group, Cambridge, UK.
Formely based at the MRC Elsie Widdowson Laboratory, Cambridge, UK.

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Classifications MeSH