Efficacy and safety of methylene blue injection for intractable idiopathic pruritus ani: a single-arm metaanalysis and systematic review.
Efficacy
Intractable idiopathic pruritus ani
Methylene blue
Safety
Journal
Techniques in coloproctology
ISSN: 1128-045X
Titre abrégé: Tech Coloproctol
Pays: Italy
ID NLM: 9613614
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
16
05
2022
accepted:
15
05
2023
medline:
11
9
2023
pubmed:
12
6
2023
entrez:
12
6
2023
Statut:
ppublish
Résumé
To evaluate how effective methylene blue injection was at treating intractable idiopathic pruritus ani. A comprehensive literature search of the PubMed, Embase, Cochrane library, and Web of Science databases was conducted. All clinical studies (prospective and retrospective) that evaluated the efficacy of methylene blue in treating intractable idiopathic pruritus ani were included. Studies that reported the resolution rate, after a single injection and after a second injection, the recurrence rate, symptom scores, and transient complications of methylene blue injections in treating intractable idiopathic pruritus ani were included. The seven selected studies included 225 patients with idiopathic pruritus ani. The resolution rates after a single injection and after a second injection was 0.761 (0.649-0.873, P < 0.01, I Using methylene blue injections to treat intractable idiopathic pruritus ani is relatively efficacious, resulting in a relatively low recurrence rate and no severe complications. However, the available literature was of poor quality. Therefore, higher quality studies are necessary to confirm that methylene blue injection is efficacious for pruritus ani, such as a randomized prospective multicenter studies.
Identifiants
pubmed: 37306793
doi: 10.1007/s10151-023-02825-y
pii: 10.1007/s10151-023-02825-y
doi:
Substances chimiques
Methylene Blue
T42P99266K
Types de publication
Systematic Review
Meta-Analysis
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
813-825Subventions
Organisme : National Natural Science Foundation of China
ID : 81704082
Organisme : The Medical Scientific Research Foundation of Zhejiang Province,China
ID : 2020RC086
Organisme : Zhejiang Traditional Chinese Medicine Scientific Research Foundation
ID : 2020ZB095
Organisme : Zhejiang Provincial Natural Science Foundation of China
ID : LQ20G030015
Informations de copyright
© 2023. Springer Nature Switzerland AG.
Références
Abramowitz L, Benabderrahmane M, Pospait D, Philip J, Laouénan C (2014) The prevalence of proctological symptoms amongst patients who see general practitioners in France. Eur J Gen Pract 20(4):301–306
doi: 10.3109/13814788.2014.899578
pubmed: 24702041
Hsieh JC, Hägermark O, Ståhle-Bäckdahl M, Ericson K, Eriksson L, Stone-Elander S, Ingvar M (1994) Urge to scratch represented in the human cerebral cortex during itch. J Neurophysiol 72(6):3004–3008
doi: 10.1152/jn.1994.72.6.3004
pubmed: 7897505
Nasseri YY, Osborne MC (2013) Pruritus ani: diagnosis and treatment. Gastroenterol Clin North Am 42(4):801–813
doi: 10.1016/j.gtc.2013.09.002
pubmed: 24280401
Oueidat D, Bou Assi T, Jurjus A (2014) Pruritus ani: more than a decade of personal experience in Lebanon. J med liban Leb med J 62(4):203–206
Etter L, Myers SA (2002) Pruritus in systemic disease: mechanisms and management. Dermatol Clin 20(3):459–472
doi: 10.1016/S0733-8635(02)00011-6
pubmed: 12170879
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71
doi: 10.1136/bmj.n71
pubmed: 33782057
pmcid: 8005924
Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y, Chipponi J (2003) Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg 73(9):712–716
doi: 10.1046/j.1445-2197.2003.02748.x
pubmed: 12956787
Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560
doi: 10.1136/bmj.327.7414.557
pubmed: 12958120
pmcid: 192859
Wolloch Y, Dintsman M (1979) A simple and effective method of treatment for intractable pruritus ani. Am J Proctol Gastroenterol Colon Rectal Surg 30(1):34–36
pubmed: 525682
Farouk R, Lee PW (1997) Intradermal methylene blue injection for the treatment of intractable idiopathic pruritus ani. Br J Surg 84(5):670
pubmed: 9171759
Botterill ID, Sagar PM (2002) Intra-dermal methylene blue, hydrocortisone and lignocaine for chronic, intractable pruritus ani. Col Dis 4(2):144–146
doi: 10.1046/j.1463-1318.2002.00329.x
Mentes BB, Akin M, Leventoglu S, Gultekin FA, Oguz M (2004) Intradermal methylene blue injection for the treatment of intractable idiopathic pruritus ani: results of 30 cases. Tech Coloproctol 8(1):11–14
doi: 10.1007/s10151-004-0043-y
pubmed: 15057582
Sutherland AD, Faragher IG, Frizelle FA (2009) Intradermal injection of methylene blue for the treatment of refractory pruritus ani. Col Dis 11(3):282–287
doi: 10.1111/j.1463-1318.2008.01587.x
Samalavicius NE, Poskus T, Gupta RK, Lunevicius R (2012) Long-term results of single intradermal 1 % methylene blue injection for intractable idiopathic pruritus ani: a prospective study. Tech Coloproctol 16(4):295–299
doi: 10.1007/s10151-012-0846-1
pubmed: 22669483
Kim JH, Kim DH, Lee YP (2019) Long-term follow-up of intradermal injection of methylene blue for intractable, idiopathic pruritus ani. Tech Coloproctol 23(2):143–149
doi: 10.1007/s10151-019-01934-x
pubmed: 30734161
pmcid: 6440940
Oz M, Lorke DE, Hasan M, Petroianu GA (2011) Cellular and molecular actions of methylene blue in the nervous system. Med Res Rev 31(1):93–117
doi: 10.1002/med.20177
pubmed: 19760660
pmcid: 3005530
Wainwright M, Crossley KB (2002) Methylene blue a therapeutic dye for all seasons? J Chemother 14(5):431–443
doi: 10.1179/joc.2002.14.5.431
pubmed: 12462423
An R (1968) Atlas of the Operations on the Rectum and Colon. Moscow Meduch Posovie. 14:431
Eusebio EB, Graham J, Mody N (1990) Treatment of intractable pruritus ani. Dis Colon Rectum 33(9):770–772
doi: 10.1007/BF02052324
pubmed: 2390913
Ortega AE, Delgadillo X (2019) Idiopathic pruritus ani and acute perianal dermatitis. Clin Colon Rectal Surg 32(5):327–332
doi: 10.1055/s-0039-1687827
pubmed: 31507341
pmcid: 6731116
Lysy J, Sistiery-Ittah M, Israelit Y, Shmueli A, Strauss-Liviatan N, Mindrul V, Keret D, Goldin E (2003) Topical capsaicin–a novel and effective treatment for idiopathic intractable pruritus ani: a randomised, placebo controlled, crossover study. Gut 52(9):1323–1326
doi: 10.1136/gut.52.9.1323
pubmed: 12912865
pmcid: 1773800
Suys E (2012) Randomized study of topical tacrolimus ointment as possible treatment for resistant idiopathic pruritus ani. J Am Acad Dermatol 66(2):327–328
doi: 10.1016/j.jaad.2011.05.024
pubmed: 22243728
Ucak H, Demir B, Cicek D, Dertlioglu SB, Akkurt ZM, Ucmak D, Halisdemir N (2013) Efficacy of topical tacrolimus for the treatment of persistent pruritus ani in patients with atopic dermatitis. J Dermatolog Treat 24(6):454–457
doi: 10.3109/09546634.2013.800181
pubmed: 23638997