Histopathological features of time-zero kidney biopsy are predictive factors for posttransplant anemia.
Journal
Kidney & blood pressure research
ISSN: 1423-0143
Titre abrégé: Kidney Blood Press Res
Pays: Switzerland
ID NLM: 9610505
Informations de publication
Date de publication:
12 Jun 2023
12 Jun 2023
Historique:
received:
26
01
2023
accepted:
25
04
2023
medline:
13
6
2023
pubmed:
13
6
2023
entrez:
12
6
2023
Statut:
aheadofprint
Résumé
Posttransplant anemia is a common complication of kidney transplantation, associated with reduced graft survival and higher mortality. We aimed to determine the association of posttransplant anemia with histopathological characteristics of time-zero allograft biopsy and donor clinical characteristics. Methods We conducted a retrospective, observational cohort study that included 587 patients who underwent kidney transplantation in our Centre. Hemoglobin levels were assessed at 6 and 12 months after transplantation, and anemia was defined according to World Health Organization criteria. The kidney allograft time-zero biopsy has been done in all investigated cases. The evaluated histopathological parameters of the kidney allografts included glomerulosclerosis, arteriolar hyalinosis, vascular fibrous intimal thickening, interstitial fibrosis, tubular atrophy, and interstitial fibrosis and tubular atrophy. The Banff Classification of Allograft Pathology criteria were followed to assess the allograft histopathological changes. Results The prevalence of anemia was 31.3% at 6 months after transplantation and 23.5% at 12 months. There was an association between 20-50% glomerulosclerosis and posttransplant anemia in both time points, independently from eGFR. Arteriolar hyalinosis and interstitial fibrosis were identified as independent risk factors for anemia at 6 months after transplantation. Conclusion Histopathological features of time-zero kidney biopsy may be predictors of PTA. Among them, our study recognized 20-50% degree of glomerulosclerosis, AH, and CV as the most significant risk factors for PTA.
Identifiants
pubmed: 37307795
pii: 000530945
doi: 10.1159/000530945
pmc: PMC10413787
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
The Author(s). Published by S. Karger AG, Basel.
Références
Transplant Proc. 2020 May;52(4):1169-1172
pubmed: 32164957
J Clin Invest. 2016 Apr 1;126(4):1425-37
pubmed: 26927670
J Am Soc Nephrol. 2016 Feb;27(2):428-38
pubmed: 26054543
Clin Transplant. 2016 Oct;30(10):1185-1194
pubmed: 27428164
Transplantation. 2012 May 15;93(9):923-8
pubmed: 22377790
Curr Opin Nephrol Hypertens. 2018 Jul;27(4):277-282
pubmed: 29746306
Transplantation. 2000 Jun 15;69(11):2388-94
pubmed: 10868646
J Clin Invest. 2016 May 2;126(5):1926-38
pubmed: 27088801
Qual Life Res. 2016 Jan;25(1):183-92
pubmed: 26169231
Kidney Int. 1984 Feb;25(2):437-44
pubmed: 6727139
Clin J Am Soc Nephrol. 2011 Jul;6(7):1794-801
pubmed: 21734096
Compr Physiol. 2011 Oct;1(4):1759-94
pubmed: 23733688
Biomed Res Int. 2017;2017:6987240
pubmed: 28401160
J Am Soc Nephrol. 2015 Dec;26(12):3162-78
pubmed: 26038526
Am J Transplant. 2017 May;17(5):1346-1357
pubmed: 27873464
J Am Soc Nephrol. 2013 Oct;24(10):1599-616
pubmed: 23833259
Transplantation. 1999 Apr 27;67(8):1162-7
pubmed: 10232568
Transplant Proc. 2015 May;47(4):1178-81
pubmed: 26036548
Acta Chir Hung. 1997;36(1-4):346-8
pubmed: 9408397
Am J Nephrol. 2015;41(4-5):337-44
pubmed: 26067713
Int Urol Nephrol. 2015 Sep;47(9):1577-85
pubmed: 26246037
Transplant Proc. 2015 Dec;47(10):2875-80
pubmed: 26707306
Clin Kidney J. 2019 Sep 24;14(1):132-138
pubmed: 33564411
Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i89-i97
pubmed: 28391346
Environ Health Prev Med. 2012 May;17(3):213-21
pubmed: 21993948
Transplant Proc. 2011 Dec;43(10):3686-9
pubmed: 22172826
Transplantation. 2007 Mar 27;83(6):671-6
pubmed: 17414693
J Am Soc Nephrol. 2006 Nov;17(11):3240-7
pubmed: 17035616
Transplantation. 2009 Jan 15;87(1):72-8
pubmed: 19136894
Am J Nephrol. 2013;38(4):267-74
pubmed: 24052081
Can J Cardiol. 2016 May;32(5):659-68
pubmed: 27118293
JAMA. 2005 Dec 7;294(21):2726-33
pubmed: 16333008
BMC Nephrol. 2018 Oct 5;19(1):252
pubmed: 30290796
Am J Transplant. 2002 May;2(5):429-35
pubmed: 12123208
Transplantation. 2006 Dec 27;82(12):1662-6
pubmed: 17198256
Pflugers Arch. 2016 Aug;468(8):1479-87
pubmed: 27220347
Am J Pathol. 2010 Jan;176(1):85-97
pubmed: 20008127
Am J Transplant. 2003 Jul;3(7):835-45
pubmed: 12814475
Transpl Int. 2011 Dec;24(12):1208-15
pubmed: 21929730
Am J Transplant. 2003;3 Suppl 4:114-25
pubmed: 12694055
Transplantation. 2008 Apr 27;85(8):1120-4
pubmed: 18431231
Transplantation. 2018 Nov;102(11):1795-1814
pubmed: 30028786