Neonatal sevoflurane exposure induces long-term changes in dendritic morphology in juvenile rats and mice.
General anesthesia
Sholl analysis
dendrite complexity
neurodevelopment
plasticity genes
spine density
Journal
Experimental biology and medicine (Maywood, N.J.)
ISSN: 1535-3699
Titre abrégé: Exp Biol Med (Maywood)
Pays: England
ID NLM: 100973463
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
medline:
17
7
2023
pubmed:
13
6
2023
entrez:
13
6
2023
Statut:
ppublish
Résumé
General anesthetics are potent neurotoxins when given during early development, causing apoptotic deletion of substantial number of neurons and persistent neurocognitive and behavioral deficits in animals and humans. The period of intense synaptogenesis coincides with the peak of susceptibility to deleterious effects of anesthetics, a phenomenon particularly pronounced in vulnerable brain regions such as subiculum. With steadily accumulating evidence confirming that clinical doses and durations of anesthetics may permanently alter the physiological trajectory of brain development, we set out to investigate the long-term consequences on dendritic morphology of subicular pyramidal neurons and expression on genes regulating the complex neural processes such as neuronal connectivity, learning, and memory. Using a well-established model of anesthetic neurotoxicity in rats and mice neonatally exposed to sevoflurane, a volatile general anesthetic commonly used in pediatric anesthesia, we report that a single 6 h of continuous anesthesia administered at postnatal day (PND) 7 resulted in lasting dysregulation in subicular mRNA levels of cAMP responsive element modulator (
Identifiants
pubmed: 37309741
doi: 10.1177/15353702231170003
pmc: PMC10350807
doi:
Substances chimiques
Sevoflurane
38LVP0K73A
Calcineurin
EC 3.1.3.16
Anesthetics, Inhalation
0
Methyl Ethers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
641-655Subventions
Organisme : NICHD NIH HHS
ID : R01 HD044517
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD097990
Pays : United States
Organisme : NICHD NIH HHS
ID : F32 HD101357
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM118197
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD080281
Pays : United States
Références
Neurobiol Dis. 2022 Dec;175:105923
pubmed: 36371060
Br J Anaesth. 2016 Jul;117(1):80-6
pubmed: 27147542
Br J Anaesth. 2013 Jun;110 Suppl 1:i29-38
pubmed: 23722059
Neurotox Res. 2010 Feb;17(2):179-88
pubmed: 19626389
Pediatrics. 2011 Nov;128(5):e1053-61
pubmed: 21969289
JAMA Netw Open. 2018 Aug 3;1(4):e181471
pubmed: 30646132
Br J Anaesth. 2022 Oct;129(4):555-566
pubmed: 35701270
Brain Res. 2010 Jan 14;1309:83-94
pubmed: 19896929
Cell. 2017 Aug 24;170(5):1000-1012.e19
pubmed: 28823555
Neurobiol Aging. 2013 Jul;34(7):1799-806
pubmed: 23465714
Alcohol. 2012 Nov;46(7):619-27
pubmed: 22840816
Nature. 2000 Apr 20;404(6780):876-81
pubmed: 10786794
J Neurosci. 2013 Apr 24;33(17):7368-83
pubmed: 23616543
Lancet. 2019 Feb 16;393(10172):664-677
pubmed: 30782342
Cereb Cortex. 2000 Oct;10(10):963-73
pubmed: 11007547
Acta Pharm Sin B. 2017 Nov;7(6):611-622
pubmed: 29159020
Toxicol Sci. 2007 Jul;98(1):145-58
pubmed: 17426105
Prog Neurobiol. 2001 Jun;64(2):129-55
pubmed: 11240210
J Autism Dev Disord. 2019 Aug;49(8):3127-3135
pubmed: 31053992
Front Neuroanat. 2019 Jun 19;13:62
pubmed: 31275118
J Comp Neurol. 1990 May 22;295(4):580-623
pubmed: 2358523
J Neurosci Methods. 2010 Jun 30;190(1):71-9
pubmed: 20438758
J Neurosci Methods. 2014 Mar 30;225:65-70
pubmed: 24485871
Epilepsy Behav. 2019 Sep;98(Pt A):101-109
pubmed: 31326869
Neurotoxicol Teratol. 2017 Mar - Apr;60:63-68
pubmed: 27876652
Anesth Analg. 2017 Dec;125(6):1988-1998
pubmed: 28857799
Br J Anaesth. 2017 Sep 01;119(3):524-531
pubmed: 28969320
Curr Pharm Des. 2012;18(38):6225-31
pubmed: 22762476
J Matern Fetal Neonatal Med. 2017 Nov;30(22):2734-2741
pubmed: 27924651
Neuroscience. 2013 Mar 13;233:54-63
pubmed: 23270857
JAMA. 2016 Jun 7;315(21):2312-20
pubmed: 27272582
J Neurosci. 2019 May 1;39(18):3454-3469
pubmed: 30804093
Nat Neurosci. 2011 Mar;14(3):285-93
pubmed: 21346746
Anesth Analg. 1995 Dec;81(6 Suppl):S4-10
pubmed: 7486147
Mol Neurobiol. 2020 Jan;57(1):208-216
pubmed: 31493241
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Mol Neurobiol. 2020 Jan;57(1):11-22
pubmed: 31512116
Int J Dev Neurosci. 2015 Dec;47(Pt B):266-77
pubmed: 26492981
Neuron. 2006 Nov 9;52(3):475-84
pubmed: 17088213
J Atten Disord. 2021 Jun;25(8):1058-1067
pubmed: 31833803
Physiol Rev. 2009 Jan;89(1):121-45
pubmed: 19126756
Aging Cell. 2014 Aug;13(4):584-95
pubmed: 24641683
J Am Acad Child Adolesc Psychiatry. 2017 Jun;56(6):466-474
pubmed: 28545751
J Atten Disord. 2018 Feb;22(3):229-239
pubmed: 26023173
Dev Neurobiol. 2017 Apr;77(4):393-404
pubmed: 27390186
Br J Anaesth. 2020 May;124(5):603-613
pubmed: 32151384
Neurotoxicol Teratol. 2011 Mar-Apr;33(2):220-30
pubmed: 21241795
Anesthesiology. 2011 Nov;115(5):992-1002
pubmed: 21909020
Anesthesiology. 2017 Aug;127(2):227-240
pubmed: 28609302
Anesthesiology. 2009 Mar;110(3):628-37
pubmed: 19212262
Anesthesiology. 2015 Nov;123(5):1084-92
pubmed: 26313293
Front Synaptic Neurosci. 2022 Sep 13;14:939793
pubmed: 36176941
Br J Anaesth. 2017 Sep 01;119(3):532-540
pubmed: 28969309
iScience. 2018 Oct 26;8:161-174
pubmed: 30317078
Anesthesiology. 2013 May;118(5):1086-97
pubmed: 23411726
Eur J Neurosci. 1998 Mar;10(3):1011-8
pubmed: 9753168
Brain Pathol. 2008 Apr;18(2):198-210
pubmed: 18241241
Mayo Clin Proc. 2012 Feb;87(2):120-9
pubmed: 22305025
Mol Neurobiol. 2018 Jan;55(1):164-172
pubmed: 28840469
J Autism Dev Disord. 2022 Oct;52(10):4301-4310
pubmed: 34618293
Bioinformatics. 2011 Sep 1;27(17):2453-4
pubmed: 21727141
Neuron. 2006 Nov 9;52(3):461-74
pubmed: 17088212
Front Psychiatry. 2021 Nov 24;12:717093
pubmed: 34899413
J Neurosci. 2003 Feb 1;23(3):876-82
pubmed: 12574416
J Clin Med. 2019 Feb 08;8(2):
pubmed: 30744008
Neurosci Res. 2019 Jun;143:1-12
pubmed: 30121285
Anesthesiology. 2016 Jun;124(6):1311-1327
pubmed: 27028464
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
Sci Rep. 2018 Jul 13;8(1):10656
pubmed: 30006558
PLoS One. 2015 Dec 04;10(12):e0144341
pubmed: 26637126
Nat Rev Neurosci. 2008 Mar;9(3):206-21
pubmed: 18270515
Nature. 2002 Dec 19-26;420(6917):788-94
pubmed: 12490942
Neurobiol Learn Mem. 2014 Nov;115:21-9
pubmed: 25173698
Gene. 2005 Aug 15;356:39-48
pubmed: 15967596
Brain Res. 1992 Sep 25;591(2):332-6
pubmed: 1359925
Anesthesiology. 2009 Apr;110(4):796-804
pubmed: 19293700
Dev Biol. 2018 Jun 15;438(2):69-83
pubmed: 29608877
Nature. 2014 Nov 27;515(7528):582-6
pubmed: 25219850
Neuroscience. 2005;133(2):463-70
pubmed: 15878241
Br J Anaesth. 2013 Jun;110 Suppl 1:i47-52
pubmed: 23616588
Int J Mol Sci. 2018 Jul 26;19(8):
pubmed: 30049952
Front Syst Neurosci. 2020 May 26;14:26
pubmed: 32528257
Neuropsychopharmacology. 2010 Jan;35(1):147-68
pubmed: 19794405