ROS-Mediated Antitumor Activity, Apoptosis, and Molecular Docking Studies of Platinum(II) Coordination Complexes Bearing 2-(Diphenylphosphino)pyridine Ligands.


Journal

Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449

Informations de publication

Date de publication:
Jul 2023
Historique:
received: 11 12 2022
accepted: 12 06 2023
medline: 24 7 2023
pubmed: 13 6 2023
entrez: 13 6 2023
Statut: ppublish

Résumé

Platinum-based drugs have been widely used in cancer treatment. However, their severe side effects have limited their use. So, researchers have been striving to find compounds with fewer side effects and greater efficacy, to overcome these drawbacks. Here, the cytotoxicity of platinum(II) complexes containing 2-(diphenylphosphino)pyridine ligands have been studied on human lung (A549), ovarian (SKOV3), breast (MCF-7) cancer, and normal breast (MCF-10A) cell lines. The most potent compound exhibits a marked cell growth-inhibitory effect against ovarian and lung cancer cells with IC

Identifiants

pubmed: 37309806
doi: 10.1002/cbdv.202201177
doi:

Substances chimiques

Platinum 49DFR088MY
Coordination Complexes 0
Reactive Oxygen Species 0
Ligands 0
Antineoplastic Agents 0
Pyridines 0
DNA 9007-49-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202201177

Subventions

Organisme : Ahvaz Jundishapur University of Medical Sciences
Organisme : Medicinal Chemistry department and Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences

Informations de copyright

© 2023 Wiley-VHCA AG, Zurich, Switzerland.

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Auteurs

Ayyub Mojaddami (A)

Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Medicinal Chemistry, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Sedigheh Abedanzadeh (S)

Faculty of Chemistry, Kharazmi University, Tehran, 15719-14911, Iran.

Mehrafarin Bagherzadeh (M)

Department of Medicinal Chemistry, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Gisou Foroutan (G)

Department of Medicinal Chemistry, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Mohammad Javad Khodayar (MJ)

Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Mohammad Panahimehr (M)

Department of Chemistry, Faculty of Basic Science, Ayatollah Boroujerdi University, Boroujerd, Iran.

Masood Fereidoonnezhad (M)

Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Medicinal Chemistry, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

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