Neuroanatomical characterization of the Nmu-Cre knock-in mice reveals an interconnected network of unique neuropeptidergic cells.

Animals Mice Neurons Integrases / genetics Neuropeptides / genetics Disease Models, Animal Peptide Hormones
knock-in mouse model neuromedin U neuropeptide ventromedial hypothalamic nucleus

Journal

Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419

Informations de publication

Date de publication:
06 2023
Historique:
medline: 15 6 2023
pubmed: 14 6 2023
entrez: 13 6 2023
Statut: ppublish

Résumé

Neuromedin U (NMU) is an evolutionary conserved neuropeptide that has been implicated in multiple processes, such as circadian regulation, energy homeostasis, reward processing and stress coping. Although the central expression of NMU has been addressed previously, the lack of specific and sensitive tools has prevented a comprehensive characterization of NMU-expressing neurons in the brain. We have generated a knock-in mouse model constitutively expressing Cre recombinase under the

Identifiants

DOI: 10.1098/rsob.220353 PMID: 37311538 PMC: PMC10264104
pubmed: 37311538
doi: 10.1098/rsob.220353
pmc: PMC10264104
doi:

Substances chimiques

Cre recombinase EC 2.7.7.-
neuromedin U 117505-80-3
Integrases EC 2.7.7.-
Neuropeptides 0
Peptide Hormones 0

Banques de données

figshare
['10.6084/m9.figshare.c.6662875']

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

220353

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Auteurs

Mireia Medrano (M)

Center for Neurosciences, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, 1090 Brussels, Belgium.

Wissal Allaoui (W)

Center for Neurosciences, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, 1090 Brussels, Belgium.

Mathias Van Bulck (M)

Laboratory of Medical and Molecular Oncology, Vrije Universiteit Brussel, 1090 Brussels, Belgium.

Sofie Thys (S)

Department of Veterinary Sciences, Laboratory of Cell Biology and Histology and Antwerp Centre for Advanced Microscopy (ACAM), University of Antwerp, 2610 Antwerp, Belgium.

Leila Makrini-Maleville (L)

IGF, Université de Montpellier, CNRS, Inserm, 34094 Montpellier, France.

Eve Seuntjens (E)

Department of Biology, Laboratory of Developmental Neurobiology, KU Leuven, 3000 Leuven, Belgium.

Winnok H De Vos (WH)

Department of Veterinary Sciences, Laboratory of Cell Biology and Histology and Antwerp Centre for Advanced Microscopy (ACAM), University of Antwerp, 2610 Antwerp, Belgium.
μNEURO Research Centre of Excellence, University of Antwerp, 2610 Antwerp, Belgium.
Antwerp Centre for Advanced Microscopy (ACAM), 2610 Wilrijk, Belgium.

Emmanuel Valjent (E)

IGF, Université de Montpellier, CNRS, Inserm, 34094 Montpellier, France.

Bálazs Gaszner (B)

Medical School, Research Group for Mood Disorders, Department of Anatomy and Centre for Neuroscience, University of Pécs, 7624 Pécs, Hungary.

Ann Van Eeckhaut (A)

Center for Neurosciences, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, 1090 Brussels, Belgium.
ORCID: 0000-0002-1695-7398

Ilse Smolders (I)

Center for Neurosciences, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, 1090 Brussels, Belgium.

Dimitri De Bundel (D)

Center for Neurosciences, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, 1090 Brussels, Belgium.
ORCID: 0000-0002-6234-9908

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Classifications MeSH

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questionsmedicales.fr › Cellules › Neurones › Neuroanatomical characterization of the...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Recombinases › Integrases › Neuroanatomical characterization of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Neuroanatomical characterization of the...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Neuroanatomical characterization of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Neuroanatomical characterization of the...