TMX4-driven LINC complex disassembly and asymmetric autophagy of the nuclear envelope upon acute ER stress.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
13 06 2023
13 06 2023
Historique:
received:
21
09
2022
accepted:
31
05
2023
medline:
15
6
2023
pubmed:
14
6
2023
entrez:
13
6
2023
Statut:
epublish
Résumé
The endoplasmic reticulum (ER) is an organelle of nucleated cells that produces proteins, lipids and oligosaccharides. ER volume and activity are increased upon induction of unfolded protein responses (UPR) and are reduced upon activation of ER-phagy programs. A specialized domain of the ER, the nuclear envelope (NE), protects the cell genome with two juxtaposed lipid bilayers, the inner and outer nuclear membranes (INM and ONM) separated by the perinuclear space (PNS). Here we report that expansion of the mammalian ER upon homeostatic perturbations results in TMX4 reductase-driven disassembly of the LINC complexes connecting INM and ONM and in ONM swelling. The physiologic distance between ONM and INM is restored, upon resolution of the ER stress, by asymmetric autophagy of the NE, which involves the LC3 lipidation machinery, the autophagy receptor SEC62 and the direct capture of ONM-derived vesicles by degradative LAMP1/RAB7-positive endolysosomes in a catabolic pathway mechanistically defined as micro-ONM-phagy.
Identifiants
pubmed: 37311770
doi: 10.1038/s41467-023-39172-3
pii: 10.1038/s41467-023-39172-3
pmc: PMC10264389
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3497Informations de copyright
© 2023. The Author(s).
Références
J Biol Chem. 2005 Jan 14;280(2):1376-83
pubmed: 15475357
J Biol Chem. 1997 May 23;272(21):13849-55
pubmed: 9153243
Mol Cell. 2019 Jun 6;74(5):891-908.e10
pubmed: 31006537
Mol Cell Biol. 2006 May;26(10):3738-51
pubmed: 16648470
Annu Rev Biochem. 2019 Jun 20;88:725-783
pubmed: 30883195
Trends Biochem Sci. 2022 Jan;47(1):52-65
pubmed: 34556392
Mol Biol Cell. 2008 Dec;19(12):5360-72
pubmed: 18843052
Mol Cell. 2019 Jun 6;74(5):909-921.e6
pubmed: 31006538
J Histochem Cytochem. 1980 Sep;28(9):997-1006
pubmed: 7410819
J Biol Chem. 1991 Sep 15;266(26):17067-71
pubmed: 1832668
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19211-6
pubmed: 19050071
Physiol Rev. 2022 Jul 1;102(3):1393-1448
pubmed: 35188422
Nat Cell Biol. 2016 Nov;18(11):1173-1184
pubmed: 27749824
Elife. 2015 May 29;4:e06980
pubmed: 26023829
J Cell Biol. 2006 Jan 2;172(1):41-53
pubmed: 16380439
J Cell Biol. 1969 Jul;42(1):92-112
pubmed: 4306789
Nat Commun. 2020 Mar 9;11(1):1274
pubmed: 32152270
J Biol Chem. 2004 Jun 11;279(24):25805-12
pubmed: 15082709
J Cell Sci. 2005 Aug 1;118(Pt 15):3419-30
pubmed: 16079285
J Struct Biol. 2017 Feb;197(2):191-198
pubmed: 27313000
Am J Anat. 1954 Mar;94(2):171-207
pubmed: 13148119
Cell. 2012 May 11;149(4):832-46
pubmed: 22579286
Nature. 2015 Apr 23;520(7548):563-6
pubmed: 25686604
Mol Biol Cell. 2007 Aug;18(8):2795-804
pubmed: 17507649
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
J Antibiot (Tokyo). 1971 Nov;24(11):785-94
pubmed: 5168706
Nature. 2004 Dec 23;432(7020):1032-6
pubmed: 15525940
Anal Chem. 2002 Oct 15;74(20):5383-92
pubmed: 12403597
Mol Biol Cell. 2006 Apr;17(4):1768-78
pubmed: 16467382
Mol Biol Cell. 2015 Oct 1;26(19):3390-400
pubmed: 26246604
Diabetologia. 2007 May;50(5):1006-14
pubmed: 17333111
Mol Biol Cell. 2020 Jul 1;31(14):1512-1524
pubmed: 32401604
Nat Cell Biol. 2014 Apr;16(4):376-81
pubmed: 24609268
J Cell Biol. 2005 Dec 5;171(5):799-810
pubmed: 16330710
J Biol Chem. 2018 Apr 13;293(15):5600-5612
pubmed: 29453283
Bioconjug Chem. 2015 Jun 17;26(6):975-86
pubmed: 25974629
Nat Rev Mol Cell Biol. 2007 Mar;8(3):258-64
pubmed: 17287811
Cells. 2020 Aug 31;9(9):
pubmed: 32878123
Hum Genomics. 2012 Jul 05;6:6
pubmed: 23245351
Nat Commun. 2019 Nov 7;10(1):5058
pubmed: 31699981
Nature. 1999 Nov 4;402(6757):90-3
pubmed: 10573423
Exp Cell Res. 1955 Feb;8(1):147-58
pubmed: 14353112
Chem Rev. 2018 Feb 14;118(3):1169-1198
pubmed: 28699750
Cold Spring Harb Perspect Biol. 2010 Mar;2(3):a000539
pubmed: 20300205
Autophagy. 2020 Feb;16(2):385-386
pubmed: 31961258
J Cell Sci. 2009 Dec 1;122(Pt 23):4287-95
pubmed: 19887585
Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4449-54
pubmed: 22392984
Cell. 2015 Dec 17;163(7):1692-701
pubmed: 26687357
PLoS Biol. 2016 Jan 04;14(1):e1002340
pubmed: 26727152
Curr Biol. 2018 Oct 8;28(19):3086-3097.e4
pubmed: 30245107
J Biol Chem. 2010 Mar 5;285(10):7135-42
pubmed: 20056998
Nature. 1996 Feb 1;379(6564):466-9
pubmed: 8559255
J Cell Biol. 1973 Mar;56(3):746-61
pubmed: 4569312
J Biol Chem. 2007 Nov 16;282(46):33859-33867
pubmed: 17881353
J Biol Chem. 2011 Jul 29;286(30):26743-53
pubmed: 21652697
J Struct Biol. 2005 Oct;152(1):36-51
pubmed: 16182563
Science. 2011 Nov 25;334(6059):1081-6
pubmed: 22116877
Nat Rev Mol Cell Biol. 2022 Sep;23(9):583-602
pubmed: 35513718
Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):
pubmed: 34290138
J Virol. 2001 Apr;75(8):3675-84
pubmed: 11264357
J Cell Sci. 2007 Oct 1;120(Pt 19):3384-94
pubmed: 17881500
Nat Cell Biol. 2009 Apr;11(4):468-76
pubmed: 19270693
Anal Chem. 1996 Mar 1;68(5):850-8
pubmed: 8779443
Anal Chem. 2003 Sep 1;75(17):4646-58
pubmed: 14632076
Cell. 2012 May 25;149(5):1035-47
pubmed: 22632968
Trends Cell Biol. 2011 Jun;21(6):362-73
pubmed: 21514163
Autophagy. 2022 Jan;18(1):40-49
pubmed: 33726628
Nucleus. 2019 Dec;10(1):126-143
pubmed: 31142202
Biol Lett. 2020 Jul;16(7):20200302
pubmed: 32634376
Nat Methods. 2017 Apr;14(4):331-332
pubmed: 28250466
J Biol Chem. 2006 Nov 10;281(45):34537-48
pubmed: 16968695
Antioxid Redox Signal. 2009 Nov;11(11):2807-50
pubmed: 19476414
Mol Biol Cell. 2011 Jul 1;22(13):2290-300
pubmed: 21525242
Nature. 2015 Jun 18;522(7556):354-8
pubmed: 26040720
Curr Opin Struct Biol. 2013 Apr;23(2):285-91
pubmed: 23597672
J Cell Biol. 2009 Nov 16;187(4):525-36
pubmed: 19948500
Nucleus. 2015;6(1):2-7
pubmed: 25425085
Annu Rev Cell Dev Biol. 2021 Oct 6;37:143-169
pubmed: 34152791
Proc R Soc Lond B Biol Sci. 1950 Oct 13;137(888):367-78
pubmed: 14786306
J Biophys Biochem Cytol. 1955 May 25;1(3):257-70
pubmed: 13242591
Mol Cell. 2019 Oct 17;76(2):268-285
pubmed: 31585693
EMBO J. 1992 May;11(5):1717-22
pubmed: 1582407
Nat Cell Biol. 2009 Apr;11(4):385-96
pubmed: 19270696
J Cell Biol. 2008 Mar 10;180(5):857-65
pubmed: 18316408
J Struct Biol. 1996 Jan-Feb;116(1):71-6
pubmed: 8742726
Curr Opin Cell Biol. 2021 Jun;70:100-108
pubmed: 33662810
Nat Rev Mol Cell Biol. 2017 Apr;18(4):229-245
pubmed: 28120913
J Cell Biol. 2014 Jul 21;206(2):163-72
pubmed: 25023515
J Struct Biol. 1997 Dec;120(3):343-52
pubmed: 9441937