Behavioral adjustment moderates the effect of neuroticism on brain volume relative to intracranial volume.
behavioral adjustment
brain volume
neuroticism
Journal
Journal of personality
ISSN: 1467-6494
Titre abrégé: J Pers
Pays: United States
ID NLM: 2985194R
Informations de publication
Date de publication:
13 Jun 2023
13 Jun 2023
Historique:
revised:
23
05
2023
received:
25
10
2022
accepted:
31
05
2023
pmc-release:
13
12
2024
medline:
14
6
2023
pubmed:
14
6
2023
entrez:
13
6
2023
Statut:
aheadofprint
Résumé
The present study examined whether the effect of neuroticism on brain structure is moderated by behavioral adjustment. Neuroticism is widely thought to be harmful to health. However, recent work using proinflammatory biomarkers showed that this effect depends on behavioral adjustment, the willingness and ability to adjust and cope with environmental contingencies, such as different opinions of others or unpredictable life situations. Here, we sought to extend this observation to "brain health" by testing total brain volume (TBV). Using a community sample of 125 Americans, we examined structural magnetic resonance imaging of the brain and quantified TBV. We tested whether the effect of neuroticism on TBV was moderated by behavioral adjustment, net of intracranial volume, age, sex, educational achievement, and race. Behavioral adjustment significantly moderated the effect of neuroticism on TBV, such that neuroticism was associated with lower TBV only when behavioral adjustment was low. There was no such effect when behavioral adjustment was high. The present findings suggest that neuroticism is not debilitating to those who constructively cope with stress. Implications are further discussed.
Sections du résumé
OBJECTIVE
OBJECTIVE
The present study examined whether the effect of neuroticism on brain structure is moderated by behavioral adjustment.
BACKGROUND
BACKGROUND
Neuroticism is widely thought to be harmful to health. However, recent work using proinflammatory biomarkers showed that this effect depends on behavioral adjustment, the willingness and ability to adjust and cope with environmental contingencies, such as different opinions of others or unpredictable life situations. Here, we sought to extend this observation to "brain health" by testing total brain volume (TBV).
METHOD
METHODS
Using a community sample of 125 Americans, we examined structural magnetic resonance imaging of the brain and quantified TBV. We tested whether the effect of neuroticism on TBV was moderated by behavioral adjustment, net of intracranial volume, age, sex, educational achievement, and race.
RESULTS
RESULTS
Behavioral adjustment significantly moderated the effect of neuroticism on TBV, such that neuroticism was associated with lower TBV only when behavioral adjustment was low. There was no such effect when behavioral adjustment was high.
CONCLUSION
CONCLUSIONS
The present findings suggest that neuroticism is not debilitating to those who constructively cope with stress. Implications are further discussed.
Identifiants
pubmed: 37311929
doi: 10.1111/jopy.12858
pmc: PMC10716358
mid: NIHMS1914836
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : U01 AG077928
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG051426
Pays : United States
Informations de copyright
© 2023 The Authors. Journal of Personality published by Wiley Periodicals LLC.
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