Tamoxifen decreases ovarian toxicity without compromising cancer treatment in a rat model of mammary cancer.

Female Animals Rats Tamoxifen / pharmacology Ovary Proteomics Cyclophosphamide / pharmacology Aggression Neoplasms
Apoptosis Cyclophosphamide Fertility preservation Tamoxifen Transcriptome/proteome Tumor-bearing rats

Journal

BMC genomics
ISSN: 1471-2164
Titre abrégé: BMC Genomics
Pays: England
ID NLM: 100965258

Informations de publication

Date de publication:
13 Jun 2023
Historique:
received: 16 09 2022
accepted: 31 05 2023
medline: 15 6 2023
pubmed: 14 6 2023
entrez: 13 6 2023
Statut: epublish

Résumé

Premenopausal women diagnosed with breast cancer often face aggressive chemotherapy resulting in infertility. Tamoxifen (TAM) is a selective estrogen receptor modulator that was previously suggested as a protective agent against chemotherapy-induced ovarian failure. In the current study, we examined mechanisms of the protective action of TAM in the ovaries of tumor-bearing rats treated with the chemotherapy drug cyclophosphamide (CPA). TAM prevented CPA-induced loss of ovarian follicular reserves. The protective TAM effect in the rat ovary partially resulted from decreased apoptosis. In addition, transcriptomic and proteomic screening also implicated the importance of DNA repair pathways as well as cell adhesion and extracellular matrix remodeling in the protective ovarian actions of TAM. Tamoxifen shielded the ovary from the side effects of chemotherapy without lessening the tumoricidal actions of mammary cancer treatment.

Sections du résumé

BACKGROUND BACKGROUND
Premenopausal women diagnosed with breast cancer often face aggressive chemotherapy resulting in infertility. Tamoxifen (TAM) is a selective estrogen receptor modulator that was previously suggested as a protective agent against chemotherapy-induced ovarian failure. In the current study, we examined mechanisms of the protective action of TAM in the ovaries of tumor-bearing rats treated with the chemotherapy drug cyclophosphamide (CPA).
RESULTS RESULTS
TAM prevented CPA-induced loss of ovarian follicular reserves. The protective TAM effect in the rat ovary partially resulted from decreased apoptosis. In addition, transcriptomic and proteomic screening also implicated the importance of DNA repair pathways as well as cell adhesion and extracellular matrix remodeling in the protective ovarian actions of TAM.
CONCLUSIONS CONCLUSIONS
Tamoxifen shielded the ovary from the side effects of chemotherapy without lessening the tumoricidal actions of mammary cancer treatment.

Identifiants

DOI: 10.1186/s12864-023-09423-0 PMID: 37312040 PMC: PMC10265842
pubmed: 37312040
doi: 10.1186/s12864-023-09423-0
pii: 10.1186/s12864-023-09423-0
pmc: PMC10265842
doi:

Substances chimiques

Tamoxifen 094ZI81Y45
Cyclophosphamide 8N3DW7272P

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

325

Subventions

Organisme : National Science Center
ID : 2016/21/B/NZ4/00202

Informations de copyright

© 2023. The Author(s).

Références

Nat Rev Clin Oncol. 2019 Jan;16(1):27-44
pubmed: 30206303
J Endocrinol. 2019 Feb 1;240(2):243-256
pubmed: 30530902
Breast Cancer Res Treat. 2014 Nov;148(2):303-14
pubmed: 25332094
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Endocrinology. 2007 Jan;148(1):206-17
pubmed: 17038561
Tumour Biol. 2015 Dec;36(12):9095-117
pubmed: 26386719
J Anim Sci Biotechnol. 2018 Oct 11;9:72
pubmed: 30338064
J Clin Med. 2021 Sep 16;10(18):
pubmed: 34575299
Gynecol Oncol. 2017 Oct;147(1):153-157
pubmed: 28662774
Exp Cell Res. 2004 Jan 1;292(1):115-22
pubmed: 14720511
Carcinogenesis. 1986 Dec;7(12):2007-14
pubmed: 2877750
Chemosphere. 2018 Dec;212:170-181
pubmed: 30144678
Cancer Lett. 2015 May 1;360(2):114-8
pubmed: 25721081
Nat Protoc. 2009;4(8):1184-91
pubmed: 19617889
Endocrinology. 2017 Oct 1;158(10):3647-3660
pubmed: 28938399
Biol Reprod. 2004 Jul;71(1):282-90
pubmed: 15028627
Hum Reprod Update. 2019 Nov 5;25(6):673-693
pubmed: 31600388
Biol Reprod. 2015 May;92(5):132
pubmed: 25833159
Nucleic Acids Res. 2000 Sep 15;28(18):3442-4
pubmed: 10982861
Int J Cancer. 2008 May 1;122(9):1923-30
pubmed: 18183577
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Genome Biol. 2014;15(12):550
pubmed: 25516281
Oncogene. 2010 Jan 14;29(2):174-87
pubmed: 19826412
Nucleic Acids Res. 2014 Jun;42(10):6270-85
pubmed: 24823795
Clin Obstet Gynecol. 2010 Dec;53(4):740-52
pubmed: 21048441
Toxicol Lett. 2002 Feb 28;127(1-3):217-24
pubmed: 12052661
Nat Biotechnol. 2019 Aug;37(8):907-915
pubmed: 31375807
Cancer Cell Int. 2021 Sep 26;21(1):514
pubmed: 34565365
Mol Oncol. 2012 Apr;6(2):222-36
pubmed: 22406404
Nat Biotechnol. 2015 Mar;33(3):290-5
pubmed: 25690850
J Clin Oncol. 2018 Jul 1;36(19):1994-2001
pubmed: 29620997
Front Biosci (Elite Ed). 2012 Jan 01;4(2):690-9
pubmed: 22201905
Chemosphere. 2017 Jul;178:368-377
pubmed: 28340459
Reprod Biol Endocrinol. 2003 Feb 06;1:11
pubmed: 12646064
J Toxicol Sci. 2009;34 Suppl 1:SP43-51
pubmed: 19265288
J Biol Chem. 2003 Nov 28;278(48):47853-61
pubmed: 14500729
Nat Cell Biol. 2002 Jan;4(1):26-31
pubmed: 11780128
Protein Expr Purif. 2009 Sep;67(1):41-7
pubmed: 19376231
Bioinformatics. 2013 Jul 15;29(14):1830-1
pubmed: 23740750
Nature. 2006 Nov 30;444(7119):624-8
pubmed: 17122775
Acta Pharmacol Sin. 2011 Feb;32(2):245-52
pubmed: 21293477
Endocrinology. 2013 Oct;154(10):3888-99
pubmed: 23798597
Jpn J Clin Oncol. 2005 Oct;35(10):607-11
pubmed: 16254040
Front Genet. 2021 Oct 29;12:714228
pubmed: 34868199
Discov Oncol. 2021 May 27;12(1):17
pubmed: 35201439
Oncogene. 2018 Feb 22;37(8):1041-1048
pubmed: 29084207
Cell Death Dis. 2018 May 3;9(5):520
pubmed: 29725084
Mol Cancer. 2011 Sep 30;10:125
pubmed: 21962244
Int J Mol Sci. 2019 Sep 23;20(19):
pubmed: 31548505
Int J Mol Sci. 2016 May 30;17(6):
pubmed: 27248997
Oncol Rep. 2021 Jan;45(1):95-106
pubmed: 33416166
Biochem Pharmacol. 2013 Feb 15;85(4):449-65
pubmed: 23103568
Ann Oncol. 2013 Mar;24(3):598-608
pubmed: 23129121
Biotech Histochem. 2019 Aug;94(6):410-419
pubmed: 31305178
Mol Hum Reprod. 2019 Aug 1;25(8):433-444
pubmed: 30953068
Apoptosis. 2001 Dec;6(6):469-77
pubmed: 11595837
Biochem Biophys Res Commun. 2018 Apr 30;499(1):93-98
pubmed: 29524404
Bioinformatics. 2015 Feb 15;31(4):608-9
pubmed: 25677125
Obstet Gynecol Sci. 2018 Sep;61(5):615-620
pubmed: 30254998
Biol Reprod. 2015 May;92(5):133
pubmed: 25810474
J Assist Reprod Genet. 2010 Nov;27(11):591-7
pubmed: 20711751
J Clin Oncol. 2013 Jul 1;31(19):2500-10
pubmed: 23715580

Auteurs

Anna Nynca (A)

Department of Animal Anatomy and Physiology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719, Olsztyn, Poland. anna.nynca@uwm.edu.pl.
ORCID: 0000-0002-1807-6148

Sylwia Swigonska (S)

Laboratory of Molecular Diagnostics, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Monika Ruszkowska (M)

Department of Human Nutrition, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Agnieszka Sadowska (A)

Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Olsztyn, Poland.

Karina Orlowska (K)

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.

Tomasz Molcan (T)

Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Olsztyn, Poland.

Kamil Myszczynski (K)

Laboratory of Translational Oncology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdansk, Poland.

Iwona Otrocka-Domagala (I)

Department of Pathological Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Katarzyna Paździor-Czapula (K)

Department of Pathological Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Beata Kurowicka (B)

Department of Animal Anatomy and Physiology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719, Olsztyn, Poland.

Brian Kelli Petroff (BK)

Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA.

Renata Elzbieta Ciereszko (RE)

Department of Animal Anatomy and Physiology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1A, 10-719, Olsztyn, Poland.
Laboratory of Molecular Diagnostics, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Tamoxifen decreases ovarian toxicity without...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Tamoxifen decreases ovarian toxicity without...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzylidéniques › Stilbènes › Tamoxifène › Tamoxifen decreases ovarian toxicity without...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Gonades › Ovaire › Tamoxifen decreases ovarian toxicity without...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Tamoxifen decreases ovarian toxicity without...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphoramides › Moutardes phosphoramide › Cyclophosphamide › Tamoxifen decreases ovarian toxicity without...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement social › Agressivité › Tamoxifen decreases ovarian toxicity without...
questionsmedicales.fr › Tumeurs › Tamoxifen decreases ovarian toxicity without...