Horsfielenigans A and B, Two Rearranged Lignans with Anti-Inflammatory Effects from Horsfieldia kingii.


Journal

Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449

Informations de publication

Date de publication:
Jul 2023
Historique:
received: 17 04 2023
accepted: 12 06 2023
medline: 23 10 2023
pubmed: 14 6 2023
entrez: 14 6 2023
Statut: ppublish

Résumé

Seven lignans were isolated from 70 % aqueous acetone extracts of the twigs and leaves of Horsfieldia kingii. Among these, new compounds 1-3 were identified by spectroscopic techniques, with horsfielenigans A and B (1 and 2) being particularly noteworthy for their rare β-benzylnaphthalene skeleton, where compound 1 contains an oxabicyclo[3,2,1]octane moiety. In vitro evaluation of bioactivity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages revealed inhibitory effects by 1 (IC

Identifiants

pubmed: 37312430
doi: 10.1002/cbdv.202300549
doi:

Substances chimiques

Lignans 0
Plant Extracts 0
Nitric Oxide 31C4KY9ESH
Lipopolysaccharides 0
Anti-Inflammatory Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202300549

Subventions

Organisme : National Natural Science Foundation of China
ID : 31460086
Organisme : Science and Technology Program of Yunnan Province
ID : 202101AT070134
Organisme : Top Young Talent of Ten Thousand Talents Program of Yunnan Province

Informations de copyright

© 2023 Wiley-VHCA AG, Zurich, Switzerland.

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Auteurs

Xian-Huan Zhang (XH)

School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, 650050, P. R. China.

Zhao Lu (Z)

School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, 650050, P. R. China.

Zhi-Yuan Li (ZY)

Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China.

Nan Fu (N)

School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, 650050, P. R. China.

Rui Zhan (R)

School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, 650050, P. R. China.

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