Acute Disorders of Consciousness in Pediatric Severe Sepsis and Organ Failure: Secondary Analysis of the Multicenter Phenotyping Sepsis-Induced Multiple Organ Failure Study.

Acute disorders of consciousness (DoC) in pediatric severe sepsis are associated with increased risk of morbidity and mortality. We sought to examine the frequency of and factors associated with DoC in children with sepsis-induced organ failure. Secondary analysis of the multicenter Phenotyping Sepsis-Induced Multiple Organ Failure Study (PHENOMS). Nine tertiary care PICUs in the United States. Children less than 18 years old admitted to a PICU with severe sepsis and at least one organ failure during a PICU stay. None. The primary outcome was frequency of DoC, defined as Glasgow Coma Scale (GCS) less than 12 in the absence of sedatives during an ICU stay, among children with severe sepsis and the following: single organ failure, nonphenotypeable multiple organ failure (MOF), MOF with one of the PHENOMS phenotypes (immunoparalysis-associated MOF [IPMOF], sequential liver failure-associated MOF, thrombocytopenia-associated MOF), or MOF with multiple phenotypes. A multivariable logistic regression analysis was performed to evaluate the association between clinical variables and organ failure groups with DoC. Of 401 children studied, 71 (18%) presented with DoC. Children presenting with DoC were older (median 8 vs 5 yr; p = 0.023), had increased hospital mortality (21% vs 10%; p = 0.011), and more frequently presented with both any MOF (93% vs 71%; p < 0.001) and macrophage activation syndrome (14% vs 4%; p = 0.004). Among children with any MOF, those presenting with DoC most frequently had nonphenotypeable MOF and IPMOF (52% and 34%, respectively). In the multivariable analysis, older age (odds ratio, 1.07; 95% CI, 1.01-1.12) and any MOF (3.22 [1.19-8.70]) were associated with DoC. One of every five children with severe sepsis and organ failure experienced acute DoC during their PICU stay. Preliminary findings suggest the need for prospective evaluation of DoC in children with sepsis and MOF.

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Copyright © 2023 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

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Dr. Cheung received funding from the Deans Summer Research Program (University of Pittsburgh School of Medicine). Dr. Kernan received funding from the Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD) (K12HD047349). Drs. Berg’s, Zuppa’s, Notterman’s, Pollack’s, Wesssel’s, Meert’s, Hall’s, Newth’s, Doctor’s, Shanley’s, Cornell’s, Harrison’s, Banks’s, Reeder’s, Holubkov’s, Fink’s, and Carcillo’s institutions received funding from the National Institutes of Health (NIH). Drs. Berg, Zuppa, Pollack, Wessel, Meert, Hall, Newth, Shanley, Harrison, Banks, Reeder, Holubkov, Carcillo, and Fink received support for article research from the NIH. Drs. Zuppa’s, Banks’s, and Carcillo’s institutions received funding from the NICHD. Dr. Hall received funding from AbbVie (service as a consultant [active]) and LaJolla Pharmaceuticals (service as a consultant [completed]). He is a consultant for the American Board of Pediatrics Pediatric Critical Care Subboard. He receives licensing income from Kiadis. Dr. Fink’s institution received funding from the NIH and Neurocritical Care Society. She is a consultant for the American Board of Pediatrics Pediatric Critical Care Subboard. Dr. Doctor’s institution received funding from the Department of Defense and KaloCyte. Dr. Holubkov received funding from Pfizer and the Physicians Committee for Responsible Medicine; he serves on Data Safety Monitoring Boards for Pfizer. Dr. Carcillo’s institution received funding from the National Institute of General Medical Sciences. Dr. Lin has disclosed that he does not have any potential conflicts of interest.