High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey.
Autoimmune diseases
COVID-19
Fatigue
Myositis
Surveys and questionnaires
Journal
Rheumatology international
ISSN: 1437-160X
Titre abrégé: Rheumatol Int
Pays: Germany
ID NLM: 8206885
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
09
04
2023
accepted:
06
05
2023
medline:
17
7
2023
pubmed:
14
6
2023
entrez:
14
6
2023
Statut:
ppublish
Résumé
Idiopathic inflammatory myopathies (IIMs) confer a significant risk of disability and poor quality of life, though fatigue, an important contributing factor, remains under-reported in these individuals. We aimed to compare and analyze differences in visual analog scale (VAS) scores (0-10 cm) for fatigue (VAS-F) in patients with IIMs, non-IIM systemic autoimmune diseases (SAIDs), and healthy controls (HCs). We performed a cross-sectional analysis of the data from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) international patient self-reported e-survey. The COVAD survey was circulated from December 2020 to August 2021, and details including demographics, COVID-19 history, vaccination details, SAID details, global health, and functional status were collected from adult patients having received at least one COVID-19 vaccine dose. Fatigue experienced 1 week prior to survey completion was assessed using a single-item 10 cm VAS. Determinants of fatigue were analyzed in regression models. Six thousand nine hundred and eighty-eight respondents (mean age 43.8 years, 72% female; 55% White) were included in the analysis. The overall VAS-F score was 3 (IQR 1-6). Patients with IIMs had similar fatigue scores (5, IQR 3-7) to non-IIM SAIDs [5 (IQR 2-7)], but higher compared to HCs (2, IQR 1-5; P < 0.001), regardless of disease activity. In adjusted analysis, higher VAS-F scores were seen in females (reference female; coefficient -0.17; 95%CI -0.21 to -13; P < 0.001) and Caucasians (reference Caucasians; coefficient -0.22; 95%CI -0.30 to -0.14; P < 0.001 for Asians and coefficient -0.08; 95%CI -0.13 to 0.30; P = 0.003 for Hispanics) in our cohort. Our study found that patients with IIMs exhibit considerable fatigue, similar to other SAIDs and higher than healthy individuals. Women and Caucasians experience greater fatigue scores, allowing identification of stratified groups for optimized multidisciplinary care and improve outcomes such as quality of life.
Identifiants
pubmed: 37314497
doi: 10.1007/s00296-023-05344-z
pii: 10.1007/s00296-023-05344-z
pmc: PMC10265550
doi:
Substances chimiques
COVID-19 Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1637-1649Subventions
Organisme : Versus Arthritis
ID : 21992
Pays : United Kingdom
Investigateurs
Bhupen Barman
(B)
Yogesh Preet Singh
(YP)
Rajiv Ranjan
(R)
Avinash Jain
(A)
Sapan C Pandya
(SC)
Rakesh Kumar Pilania
(RK)
Aman Sharma
(A)
M Manesh Manoj
(MM)
Vikas Gupta
(V)
Chengappa G Kavadichanda
(CG)
Pradeepta Sekhar Patro
(PS)
Sajal Ajmani
(S)
Sanat Phatak
(S)
Rudra Prosad Goswami
(RP)
Abhra Chandra Chowdhury
(AC)
Ashish Jacob Mathew
(AJ)
Padnamabha Shenoy
(P)
Ajay Asranna
(A)
Keerthi Talari Bommakanti
(KT)
Anuj Shukla
(A)
Arunkumar R Pande
(AR)
Kunal Chandwar
(K)
Döndü Üsküdar Cansu
(DÜ)
John D Pauling
(JD)
Chris Wincup
(C)
Nicoletta Del Papa
(ND)
Gianluca Sambataro
(G)
Atzeni Fabiola
(A)
Marcello Govoni
(M)
Simone Parisi
(S)
Elena Bartoloni Bocci
(EB)
Gian Domenico Sebastiani
(GD)
Enrico Fusaro
(E)
Marco Sebastiani
(M)
Luca Quartuccio
(L)
Franco Franceschini
(F)
Pier Paolo Sainaghi
(PP)
Giovanni Orsolini
(G)
Rossella De Angelis
(R)
Maria Giovanna Danielli
(MG)
Vincenzo Venerito
(V)
Lisa S Traboco
(LS)
Suryo Anggoro Kusumo Wibowo
(SAK)
Jorge Rojas Serrano
(JR)
Ignacio García-De La Torre
(IG)
Erick Adrian Zamora Tehozol
(EAZ)
Jesús Loarce-Martos
(J)
Sergio Prieto-González
(S)
Raquel Aranega Gonzalez
(RA)
Akira Yoshida
(A)
Ran Nakashima
(R)
Shinji Sato
(S)
Naoki Kimura
(N)
Yuko Kaneko
(Y)
Stylianos Tomaras
(S)
Margarita Aleksandrovna Gromova
(MA)
Or Aharonov
(O)
Ihsane Hmamouchi
(I)
Leonardo Santos Hoff
(LS)
Margherita Giannini
(M)
François Maurier
(F)
Julien Campagne
(J)
Alain Meyer
(A)
Melinda Nagy-Vincze
(M)
Daman Langguth
(D)
Vidya Limaye
(V)
Merrilee Needham
(M)
Nilesh Srivastav
(N)
Marie Hudson
(M)
Océane Landon-Cardinal
(O)
Syahrul Sazliyana Shaharir
(SS)
Wilmer Gerardo Rojas Zuleta
(WGR)
José António Pereira Silva
(JAP)
João Eurico Fonseca
(JE)
Informations de copyright
© 2023. The Author(s).
Références
Clin Rev Allergy Immunol. 2018 Dec;55(3):352-367
pubmed: 28853005
Int J Nurs Stud. 2020 Nov;111:103707
pubmed: 32920423
Clinics (Sao Paulo). 2022 Apr 11;77:100031
pubmed: 35421763
Psychiatry Res. 1991 Mar;36(3):291-8
pubmed: 2062970
J Rheumatol. 2008 Dec;35(12):2339-43
pubmed: 19004044
Rheumatol Int. 2022 Jan;42(1):23-29
pubmed: 34779868
Rheumatology (Oxford). 2022 Dec 23;62(1):65-76
pubmed: 35713499
BMC Rheumatol. 2020 Sep 21;4:47
pubmed: 32974608
Nat Commun. 2022 Aug 30;13(1):5104
pubmed: 36042189
Curr Rheumatol Rep. 2019 Nov 19;21(11):62
pubmed: 31741079
J Med Internet Res. 2004 Sep 29;6(3):e34
pubmed: 15471760
J Neurol. 2014 May;261(5):992-8
pubmed: 24658663
Arthritis Care Res (Hoboken). 2017 Nov;69(11):1743-1750
pubmed: 28118525
BMJ Open. 2022 Nov 1;12(11):e065709
pubmed: 36319188
Curr Opin Rheumatol. 2017 May;29(3):269-276
pubmed: 28207494
Rheumatol Int. 2022 Dec;42(12):2151-2158
pubmed: 35964271
J Transl Autoimmun. 2019 Oct 08;2:100018
pubmed: 32743506
Front Immunol. 2019 Aug 06;10:1827
pubmed: 31447842
J Neurol. 2011 Sep;258(9):1581-92
pubmed: 21597956
J Clin Med. 2021 Aug 13;10(16):
pubmed: 34441861
PLoS One. 2016 Aug 09;11(8):e0160753
pubmed: 27504827
Rheumatology (Oxford). 2023 Feb 1;62(2):785-793
pubmed: 35866618
Int J Rheum Dis. 2020 Aug;23(8):1088-1093
pubmed: 32597545
PLoS One. 2017 Dec 19;12(12):e0189840
pubmed: 29261752
Semin Arthritis Rheum. 2021 Jun;51(3):539-546
pubmed: 33894634
J Rheumatol. 2019 Oct;46(10):1351-1354
pubmed: 30770504
J Transl Med. 2018 Jul 11;16(1):192
pubmed: 29996887