Postabsorptive muscle protein synthesis is higher in outpatients as compared to inpatients.
design
inpatient
muscle
outpatient
steps
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 08 2023
01 08 2023
Historique:
pmc-release:
01
08
2024
medline:
12
7
2023
pubmed:
14
6
2023
entrez:
14
6
2023
Statut:
ppublish
Résumé
Several factors affect muscle protein synthesis (MPS) in the postabsorptive state. Extreme physical inactivity (e.g., bedrest) may reduce basal MPS, whereas walking may augment basal MPS. We hypothesized that outpatients would have a higher postabsorptive MPS than inpatients. To test this hypothesis, we conducted a retrospective analysis. We compared 152 outpatient participants who arrived at the research site the morning of the MPS assessment with 350 Inpatient participants who had an overnight stay in the hospital unit before the MPS assessment the following morning. We used stable isotopic methods and collected vastus lateralis biopsies ∼2 to 3 h apart to assess mixed MPS. MPS was ∼12% higher (
Identifiants
pubmed: 37315157
doi: 10.1152/ajpendo.00144.2023
pmc: PMC10393319
doi:
Substances chimiques
Muscle Proteins
0
Banques de données
figshare
['10.6084/m9.figshare.23387204']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
E113-E118Subventions
Organisme : NIA NIH HHS
ID : R01 AG050781
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG074535
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR049877
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG024832
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG020532
Pays : United States
Références
J Appl Physiol (1985). 2022 Sep 1;133(3):777-785
pubmed: 35952344
Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E513-22
pubmed: 15149953
J Appl Physiol (1985). 2011 Feb;110(2):480-91
pubmed: 21109595
JAMA. 2007 Apr 25;297(16):1772-4
pubmed: 17456818
Lancet. 1988 Oct 1;2(8614):767-70
pubmed: 2901612
J Nutr. 2019 Jul 1;149(7):1149-1158
pubmed: 31095313
J Appl Physiol (1985). 2009 Jun;106(6):2026-39
pubmed: 19164770
Nutr Metab (Lond). 2021 Jun 12;18(1):61
pubmed: 34118944
J Hosp Med. 2015 Jun;10(6):384-9
pubmed: 25755217
Am J Physiol. 1996 Apr;270(4 Pt 1):E627-33
pubmed: 8928769
Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1113-22
pubmed: 22338078
J Phys Act Health. 2010 Sep;7(5):662-70
pubmed: 20864763
J Am Geriatr Soc. 2019 Feb;67(2):261-268
pubmed: 30452084
J Nutr. 2016 Dec;146(12):2468-2475
pubmed: 27798330
J Appl Physiol (1985). 2010 May;108(5):1199-209
pubmed: 20150565
PLoS One. 2015 Nov 04;10(11):e0140903
pubmed: 26536130
J Physiol. 2007 Nov 15;585(Pt 1):241-51
pubmed: 17901116
J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):57-62
pubmed: 25056502
J Nutr. 2013 Apr;143(4):410-6
pubmed: 23343671
J Appl Physiol (1985). 2009 Sep;107(3):645-54
pubmed: 19608931
J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1170-7
pubmed: 22859389
Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R708-14
pubmed: 19118097
J Appl Physiol (1985). 2010 May;108(5):1410-6
pubmed: 20203068
Exp Gerontol. 2015 May;65:1-7
pubmed: 25735236
Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E354-61
pubmed: 19934404
Exerc Sport Sci Rev. 2022 Jan 1;50(1):31-37
pubmed: 34669625
J Clin Endocrinol Metab. 2005 Sep;90(9):5175-81
pubmed: 15972575
J Appl Physiol (1985). 1997 Mar;82(3):807-10
pubmed: 9074967
Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E479-85
pubmed: 15507532
Am J Clin Nutr. 2017 Feb;105(2):332-342
pubmed: 27903518
Clin Sci (Lond). 1987 Apr;72(4):503-9
pubmed: 2435445
Skelet Muscle. 2011 Mar 02;1(1):11
pubmed: 21798089
JAMA. 2001 Sep 12;286(10):1206-12
pubmed: 11559266
Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1254-62
pubmed: 20720176
Eur J Appl Physiol. 2017 May;117(5):853-866
pubmed: 28280974
Metabolism. 2011 May;60(5):689-97
pubmed: 20822780
J Physiol. 2008 Dec 15;586(24):6049-61
pubmed: 18955382