Bottom-Up Preparation of Phase-Separated Polymersomes.
drug delivery
phase separation
polymersomes
self-assembly
vesicles
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
revised:
20
05
2023
received:
20
02
2023
medline:
21
8
2023
pubmed:
14
6
2023
entrez:
14
6
2023
Statut:
ppublish
Résumé
A bottom-up approach to fabricating monodisperse, two-component polymersomes that possess phase-separated ("patchy") chemical topology is presented. This approach is compared with already-existing top-down preparation methods for patchy polymer vesicles, such as film rehydration. These findings demonstrate a bottom-up, solvent-switch self-assembly approach that produces a high yield of nanoparticles of the target size, morphology, and surface topology for drug delivery applications, in this case patchy polymersomes of a diameter of ≈50 nm. In addition, an image processing algorithm to automatically calculate polymersome size distributions from transmission electron microscope images based on a series of pre-processing steps, image segmentation, and round object identification is presented.
Identifiants
pubmed: 37315231
doi: 10.1002/mabi.202300068
doi:
Substances chimiques
Polymers
0
Solvents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300068Informations de copyright
© 2023 Wiley-VCH GmbH.
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