Synthesis, activity, metabolic stability and cell permeability of new cytosolic phospholipase A

Humans Structure-Activity Relationship Group IV Phospholipases A2 / metabolism Caco-2 Cells Indoles / chemistry Ketones / chemistry Enzyme Inhibitors / chemistry
Caco-2 cell permeation Carbonyl reductase Cytosolic phospholipase A(2)α Glucuronosyltransferase Inhibitor Metabolic stability

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
15 08 2023
Historique:
received: 03 05 2023
revised: 23 05 2023
accepted: 07 06 2023
medline: 23 10 2023
pubmed: 15 6 2023
entrez: 14 6 2023
Statut: ppublish

Résumé

Cytosolic phospholipase A

Identifiants

DOI: 10.1016/j.bmcl.2023.129374 PMID: 37315699
pubmed: 37315699
pii: S0960-894X(23)00252-4
doi: 10.1016/j.bmcl.2023.129374
pii:
doi:

Substances chimiques

Group IV Phospholipases A2 EC 3.1.1.4
Indoles 0
Ketones 0
Enzyme Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

129374

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Angelina Subeska (A)

Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstrasse 48, 48149 Münster, Germany.

Merlin Ekodo Voundi (ME)

Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstrasse 48, 48149 Münster, Germany.

Walburga Hanekamp (W)

Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstrasse 48, 48149 Münster, Germany.

Dennis Mulac (D)

Institute of Pharmaceutical Technology and Biopharmacy, University of Münster, Corrensstrasse 48, 48149 Münster, Germany.

Klaus Langer (K)

Institute of Pharmaceutical Technology and Biopharmacy, University of Münster, Corrensstrasse 48, 48149 Münster, Germany.

Matthias Lehr (M)

Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstrasse 48, 48149 Münster, Germany. Electronic address: lehrm@uni-muenster.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis, activity, metabolic stability and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis, activity, metabolic stability and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Phospholipases A › Phospholipases A2 › Cytosolic phospholipases A2 › Group IV phospholipases A2 › Synthesis, activity, metabolic stability and...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Synthesis, activity, metabolic stability and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Synthesis, activity, metabolic stability and...
questionsmedicales.fr › Composés chimiques organiques › Cétones › Synthesis, activity, metabolic stability and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Synthesis, activity, metabolic stability and...