Metabolic Engineering of Model Microorganisms for the Production of Xanthophyll.
biosynthetic pathway
metabolic engineering
model microorganisms
xanthophyll
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
09 May 2023
09 May 2023
Historique:
received:
06
03
2023
revised:
19
04
2023
accepted:
06
05
2023
medline:
15
6
2023
pubmed:
15
6
2023
entrez:
15
6
2023
Statut:
epublish
Résumé
Xanthophyll is an oxidated version of carotenoid. It presents significant value to the pharmaceutical, food, and cosmetic industries due to its specific antioxidant activity and variety of colors. Chemical processing and conventional extraction from natural organisms are still the main sources of xanthophyll. However, the current industrial production model can no longer meet the demand for human health care, reducing petrochemical energy consumption and green sustainable development. With the swift development of genetic metabolic engineering, xanthophyll synthesis by the metabolic engineering of model microorganisms shows great application potential. At present, compared to carotenes such as lycopene and β-carotene, xanthophyll has a relatively low production in engineering microorganisms due to its stronger inherent antioxidation, relatively high polarity, and longer metabolic pathway. This review comprehensively summarized the progress in xanthophyll synthesis by the metabolic engineering of model microorganisms, described strategies to improve xanthophyll production in detail, and proposed the current challenges and future efforts needed to build commercialized xanthophyll-producing microorganisms.
Identifiants
pubmed: 37317226
pii: microorganisms11051252
doi: 10.3390/microorganisms11051252
pmc: PMC10223009
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 31901661
Organisme : Foundation of Hainan Yazhou Bay Seed Lab
ID : B21HJ0212
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