The effect of propolis supplementation in improving antioxidant status: A systematic review and meta-analysis of controlled clinical trials.
meta-analysis
oxidative stress
propolis
systematic review
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
revised:
20
03
2023
received:
21
11
2022
accepted:
09
05
2023
medline:
7
9
2023
pubmed:
15
6
2023
entrez:
15
6
2023
Statut:
ppublish
Résumé
The present study aimed to assess the effect of propolis supplementation on oxidative status, a key contributor to the etiology of many chronic diseases. A systematic search of multiple databases, including Web of Science, SCOPUS, Embase, PubMed, and Google Scholar, was conducted from inception to October 2022 to identify articles examining the effect of propolis on glutathione (GSH), glutathione peroxidase (GPX), total antioxidant capacity (TAC), superoxide dismutase (SOD), and malondialdehyde (MDA) levels. The quality of the included studies was evaluated using the Cochrane Collaboration tool. A total of nine studies were included in the final analysis, and a random-effects model was used to pool the estimated effects. Results showed that propolis supplementation significantly increased the levels of GSH (SMD = 3.16; 95% CI: 1.15, 5.18; I
Substances chimiques
Antioxidants
0
Propolis
9009-62-5
Superoxide Dismutase
EC 1.15.1.1
Glutathione Peroxidase
EC 1.11.1.9
Biomarkers
0
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3712-3723Subventions
Organisme : Student Research Committee of Tabriz University of Medical Sciences
ID : 68028
Informations de copyright
© 2023 John Wiley & Sons Ltd.
Références
Afsharpour, F., Javadi, M., Hashemipour, S., & Koushan, Y. (2019). Propolis supplementation improves glycemic and antioxidant status in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study. Complementary Therapies in Medicine, 43, 283-288.
Aleksandrova, K., Koelman, L., & Rodrigues, C. E. (2021). Dietary patterns and biomarkers of oxidative stress and inflammation: A systematic review of observational and intervention studies. Redox Biology, 42, 101869.
Asgharpour, F., Moghadamnia, A. A., Kazemi, S., Nouri, H. R., & Motallebnejad, M. (2020). Applying GC-MS analysis to identify chemical composition of Iranian propolis prepared with different solvent and evaluation of its biological activity. Caspian Journal of Internal Medicine, 11(2), 191-198.
Banskota, A. H., Tezuka, Y., & Kadota, S. (2001). Recent progress in pharmacological research of propolis. Phytotherapy Research, 15(7), 561-571.
Betteridge, D. J. (2000). What is oxidative stress? Metabolism, 49(2), 3-8.
Cao, X.-P., Chen, Y.-F., Zhang, J.-L., You, M.-M., Wang, K., & Hu, F.-L. (2017). Mechanisms underlying the wound healing potential of propolis based on its in vitro antioxidant activity. Phytomedicine, 34, 76-84.
Choi, Y., Noh, D., Cho, S., Suh, H., Kim, K., & Kim, J. (2006). Antioxidant and antimicrobial activities of propolis from several regions of Korea. LWT-Food Science and Technology, 39(7), 756-761.
Darvishi, N., Yousefinejad, V., Akbari, M. E., Abdi, M., Moradi, N., Darvishi, S., … Ghaderi, B. (2020). Antioxidant and anti-inflammatory effects of oral propolis in patients with breast cancer treated with chemotherapy: A randomized controlled trial. Journal of Herbal Medicine, 23, 100385.
Ebeid, S. A., Abd El Moneim, N. A., El-Benhawy, S. A., Hussain, N. G., & Hussain, M. I. (2016). Assessment of the radioprotective effect of propolis in breast cancer patients undergoing radiotherapy. New perspective for an old honey bee product. Journal of Radiation Research and Applied Sciences, 9(4), 431-440.
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315(7109), 629-634.
Farias, J. H. C. d., Reis, A. S., Araújo, M. A. R., Araújo, M. J. A. M., Assunção, A. K. M., Farias, J. C. d., … Guerra, R. N. M. (2014). Effects of stingless bee propolis on experimental asthma. Based Complementary and Alternative Medicine, 2014, 951478.
Gao, W., Pu, L., Wei, J., Yao, Z., Wang, Y., Shi, T., … Guo, C. (2018). Serum antioxidant parameters are significantly increased in patients with type 2 diabetes mellitus after consumption of Chinese propolis: A randomized controlled trial based on fasting serum glucose level. Diabetes Therapy, 9(1), 101-111.
Gaweł, S., Wardas, M., Niedworok, E., & Wardas, P. (2004). Malondialdehyde (MDA) as a lipid peroxidation marker. Wiadomosci Lekarskie (Warsaw, Poland: 1960), 57(9-10), 453-455.
Ghisalberti, E. (1979). Propolis: A review. Bee World, 60(2), 59-84.
Gholaminejad, F., Javadi, M., Karami, A. A., Alizadeh, F., Kavianpour, M., & Khadem Haghighian, H. (2019). Propolis supplementation effects on semen parameters, oxidative stress, inflammatory biomarkers and reproductive hormones in infertile men with asthenozoospermia; a randomized clinical trial. International Journal of Medical Laboratory, 6(1), 21-32.
Hallajzadeh, J., Milajerdi, A., Amirani, E., Attari, V. E., Maghsoudi, H., & Mirhashemi, S. M. (2021). Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: A systematic review and meta-analysis of randomized controlled clinical trials. Journal of Diabetes & Metabolic Disorders, 20(1), 831-843.
Higgins, J. (2011). Cochrane handbook for systematic reviews of interventions. Version 5.1. 0 [updated March 2011]. The Cochrane Collaboration. www.cochrane-handbook.org
Hotta, S., Uchiyama, S., & Ichihara, K. (2020). Brazilian red propolis extract enhances expression of antioxidant enzyme genes in vitro and in vivo. Bioscience, Biotechnology, and Biochemistry, 84(9), 1820-1830.
Hutcheson, R., & Rocic, P. (2012). The metabolic syndrome, oxidative stress, environment, and cardiovascular disease: The great exploration. Experimental Diabetes Research, 2012, 1-13.
Ichikawa, H., Satoh, K., Tobe, T., Yasuda, I., Ushio, F., Matsumoto, K., … Ookubo, C. (2002). Free radical scavenging activity of propolis. Redox Report, 7(5), 347-350.
Ishige, K., Schubert, D., & Sagara, Y. (2001). Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radical Biology and Medicine, 30(4), 433-446.
Ji, L. L., & Yeo, D. (2021). Oxidative stress: An evolving definition. Faculty Reviews, 10.
Jin, X., Liu, Q., Jia, L., Li, M., & Wang, X. (2015). Pinocembrin attenuates 6-OHDA-induced neuronal cell death through Nrf2/ARE pathway in SH-SY5Y cells. Cellular and Molecular Neurobiology, 35(3), 323-333.
Karimian, J., Hadi, A., Pourmasoumi, M., Najafgholizadeh, A., & Ghavami, A. (2019). The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta-analysis. Phytotherapy Research, 33(6), 1616-1626.
Kurek-Górecka, A., Rzepecka-Stojko, A., Górecki, M., Stojko, J., Sosada, M., & Świerczek-Zięba, G. (2013). Structure and antioxidant activity of polyphenols derived from propolis. Molecules, 19(1), 78-101.
Lee, Y., Shin, D.-H., Kim, J.-H., Hong, S., Choi, D., Kim, Y.-J., … Jung, Y. (2010). Caffeic acid phenethyl ester-mediated Nrf2 activation and IκB kinase inhibition are involved in NFκB inhibitory effect: Structural analysis for NFκB inhibition. European Journal of Pharmacology, 643(1), 21-28.
Levonen, A.-L., Inkala, M., Heikura, T., Jauhiainen, S., Jyrkkänen, H.-K., Kansanen, E., … Rutanen, J. (2007). Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(4), 741-747.
Mapesa, J. O., Waldschmitt, N., Schmoeller, I., Blume, C., Hofmann, T., Mahungu, S., … Haller, D. (2012). Catechols in caffeic acid phenethyl ester are essential for inhibition of TNF-mediated IP-10 expression through NF-jB-dependent but HO-1-and p38-independent mechanisms in mouse intestinal epithelial cells. Molecular Nutrition & Food Research, 55(12), 1850-1861.
Misir, S., Aliyazicioğlu, Y., Demir, S., Turan, I., Yaman, S., & Değer, O. (2018). Antioxidant properties and protective effect of Turkish propolis on t-BHP-induced oxidative stress in foreskin fibroblast cells. Indian Journal of Pharmaceutical Education and Research, 52(1), 94-100.
Mittlböck, M., & Heinzl, H. (2006). A simulation study comparing properties of heterogeneity measures in meta-analyses. Statistics in Medicine, 25(24), 4321-4333.
Mujica, V., Orrego, R., Pérez, J., Romero, P., Ovalle, P., Zúñiga-Hernández, J., Arredondo, M., & Leiva, E. (2017). The role of Propolis in oxidative stress and lipid metabolism: A randomized controlled trial. Evidence-Based Complementary and Alternative Medicine, 2017, 4272940.
Natarajan, K., Singh, S., Burke, T. R., Jr., Grunberger, D., & Aggarwal, B. B. (1996). Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proceedings of the National Academy of Sciences, 93(17), 9090-9095.
Pahlavani, N., Malekahmadi, M., Sedaghat, A., Rostami, A., Alkadir, O. K. A., Taifi, A., … Beigmohammadi, M. T. (2022). Effects of melatonin and Propolis supplementation on inflammation, oxidative stress, and clinical outcomes in patients with primary pneumosepsis: A randomized controlled clinical trial. Complementary Medicine Research, 29, 1-11.
Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017). Oxidative stress: Harms and benefits for human health. Oxidative Medicine and Cellular Longevity, 2017, 1-13.
Salatino, A., Fernandes-Silva, C. C., Righi, A. A., & Salatino, M. L. F. (2011). Propolis research and the chemistry of plant products. Natural Product Reports, 28(5), 925-936.
Sforcin, J. M. (2016). Biological properties and therapeutic applications of propolis. Phytotherapy Research, 30(6), 894-905.
Sforcin, J. M., Bankova, V., & Kuropatnicki, A. K. (2017). Medical benefits of honeybee products. Evidence-Based Complementary and Alternative Medicine, 2017 Hindawi.
Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., … Peluso, I. (2020). Lifestyle, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases. Frontiers in Physiology, 11, 694.
Shehata, M. G., Ahmad, F. T., Badr, A. N., Masry, S. H., & El-Sohaimy, S. A. (2020). Chemical analysis, antioxidant, cytotoxic and antimicrobial properties of propolis from different geographic regions. Annals of Agricultural Sciences, 65(2), 209-217.
Sies, H. (2007). Total antioxidant capacity: Appraisal of a concept. The Journal of Nutrition, 137(6), 1493-1495.
Soleimani, D., Miryan, M., Hadi, V., Gholizadeh Navashenaq, J., Moludi, J., Sayedi, S. M., … Sadeghi, E. (2021). Effect of propolis supplementation on athletic performance, body composition, inflammation, and oxidative stress following intense exercise: A triple-blind randomized clinical trial. Food Science & Nutrition, 9(7), 3631-3640.
Tapas, A. R., Sakarkar, D., & Kakde, R. (2008). Flavonoids as nutraceuticals: A review. Tropical Journal of Pharmaceutical Research, 7(3), 1089-1099.
Tinelli, C., Di Pino, A., Ficulle, E., Marcelli, S., & Feligioni, M. (2019). Hyperhomocysteinemia as a risk factor and potential nutraceutical target for certain pathologies. Frontiers in Nutrition, 6, 49.
Toreti, V. C., Sato, H. H., Pastore, G. M., & Park, Y. K. (2013). Recent Progress of Propolis for its biological and chemical compositions and its botanical origin. Evidence-Based Complementary and Alternative Medicine, 2013, 13.
Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., & Pérez-Álvarez, J. (2008). Functional properties of honey, propolis, and royal jelly. Journal of Food Science, 73(9), R117-R124.
Vona, R., Gambardella, L., Cittadini, C., Straface, E., & Pietraforte, D. (2019). Biomarkers of oxidative stress in metabolic syndrome and associated diseases. Oxidative medicine and cellular longevity, 2019.
Wagh, V. D. (2013). Propolis: A wonder bees product and its pharmacological potentials. Advances in Pharmacological Sciences, 2013, 1-11.
Wagh, V. D., & Borkar, R. D. (2012). Indian propolis: A potential natural antimicrobial and antifungal agent. International Journal of Pharmacy and Pharmaceutical Sciences, 4(4), 12-17.
Williamson, E. M., Liu, X., & Izzo, A. A. (2020). Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals. British Journal of Pharmacology, 177(6), 1227-1240.
Zhao, L., Pu, L., Wei, J., Li, J., Wu, J., Xin, Z., … Guo, C. (2016). Brazilian green propolis improves antioxidant function in patients with type 2 diabetes mellitus. International Journal of Environmental Research and Public Health, 13(5), 498.