Risk factors for obesity in adulthood among survivors of childhood cancer.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
22
02
2023
received:
24
09
2022
accepted:
19
03
2023
medline:
29
6
2023
pubmed:
15
6
2023
entrez:
15
6
2023
Statut:
ppublish
Résumé
The aim of this study was to identify risk factors for obesity in childhood cancer survivors (CCSs). The study included 3199 patients of the French Childhood Cancer Survivor Study cohort, with 303 patients with obesity who had returned the self-questionnaire. Analyses were adjusted for social deprivation index and sex. CCSs were less likely to have obesity (9.5%; 95% CI: 8.5%-10.5%) than expected from the general French population rates (12.5%; p = 0.0001). Nevertheless, brain tumor survivors were significantly more likely to develop obesity than the general French population (p = 0.0001). Compared with patients who did not receive radiotherapy to the pituitary gland, those who received a dose >5 Gy had an increased risk of obesity: relative risk 1.9 (95% CI: 1.2-3.1), 2.5 (95% CI: 1.7-3.7), and 2.6 (95% CI: 1.6-4.3), respectively, for participants with 6 to 20 Gy, 20 to 40 Gy, and ≥40 Gy of radiation. Etoposide administration significantly increased the risk of obesity (relative risk 1.7; 95% CI: 1.1-2.6). High social deprivation index was also a risk factor, just like BMI at diagnosis. Long-term follow-up of CCSs should include weight follow-up during adulthood.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1942-1952Informations de copyright
© 2023 The Obesity Society.
Références
Panorama des cancers en France, Edition 2021. Institut National du Cancer; 2021.
Berger C, El Fayech C, Pacquement H, et al. Objectives and organization for the long-term follow-up after childhood cancer. Article in French. Bull Cancer. 2015;102(7-8):579-585.
Sante publique France. Les résultats de l'étude ESTEBAN 2014-2015. Published June 26, 2019. https://www.santepubliquefrance.fr/determinants-de-sante/nutrition-et-activite-physique/articles/les-resultats-de-l-etude-esteban-2014-2015
Browne EK, Zhou Y, Chemaitilly W, et al. Changes in body mass index, height, and weight in children during and after therapy for acute lymphoblastic leukemia. Cancer. 2018;124(21):4248-4259.
Belle FN, Weiss A, Schindler M, et al. Overweight in childhood cancer survivors: the Swiss Childhood Cancer Survivor Study. Am J Clin Nutr. 2018;107(1):3-11.
Gance-Cleveland B, Linton A, Arbet J, Stiller D, Sylvain G. Predictors of overweight and obesity in childhood cancer survivors. J Pediatr Oncol Nurs. 2020;37:154. doi:10.1177/1043454219897102
van Santen HM, Geskus RB, Raemaekers S, et al. Changes in body mass index in long-term childhood cancer survivors. Cancer. 2015;121(23):4197-4204.
Gunn HM, Emilsson H, Gabriel M, Maguire AM, Steinbeck KS. Metabolic health in childhood cancer survivors: a longitudinal study in a long-term follow-up clinic. J Adolesc Young Adult Oncol. 2016;5(1):24-30.
Lustig RH, Post SR, Srivannaboon K, et al. Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab. 2003;88(2):611-616.
Park SW, Jung HW, Lee YA, et al. Tumor origin and growth pattern at diagnosis and surgical hypothalamic damage predict obesity in pediatric craniopharyngioma. J Neurooncol. 2013;113(3):417-424.
Lek N, Prentice P, Williams RM, Ong KK, Burke GAA, Acerini CL. Risk factors for obesity in childhood survivors of suprasellar brain tumours: a retrospective study. Acta Paediatr. 2010;99(10):1522-1526.
Howell CR, Wilson CL, Yasui Y, et al. Neighborhood effect and obesity in adult survivors of pediatric cancer: a report from the St. Jude lifetime cohort study. Int J Cancer. 2019;47:338-349.
Brown AL, Lupo PJ, Danysh HE, Okcu MF, Scheurer ME, Kamdar KY. Prevalence and predictors of overweight and obesity among a multiethnic population of pediatric acute lymphoblastic leukemia survivors: a cross-sectional assessment. J Pediatr Hematol Oncol. 2016;38(6):429-436.
Demoor-Goldschmidt C, Allodji RS, Journy N, et al. Risk factors for small adult height in childhood cancer survivors. J Clin Oncol. 2020;38:1785-1796.
Rey G, Jougla E, Fouillet A, Hémon D. Ecological association between a deprivation index and mortality in France over the period 1997-2001: variations with spatial scale, degree of urbanicity, age, gender and cause of death. BMC Public Health. 2009;9:33. doi:10.1186/1471-2458-9-33
Temam S, Varraso R, Pornet C, et al. Ability of ecological deprivation indices to measure social inequalities in a French cohort. BMC Public Health. 2017;17(1):956. doi:10.1186/s12889-017-4967-3
Institut national de la statistique et des etudes economiques. Consulter la PCS 2020. Groupe socioprofessional 1: Agriculteurs exploitants/Agricultrices exploitantes. Published January 1, 2021. https://www.insee.fr/fr/metadonnees/pcs2020/groupeSocioprofessionnel/1?champRecherche=true
Müller HL, Gebhardt U, Teske C, et al. Post-operative hypothalamic lesions and obesity in childhood craniopharyngioma: results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3-year follow-up. Eur J Endocrinol. 2011;165(1):17-24.
INSERM, Kantar Health, Roche. ObEpi. Enquête épidémiologique nationale sur le surpoids et l'obésité. Published 2012. https://presse.inserm.fr/wp-content/uploads/2012/10/obepi_2012.pdf
Isambert A, Beaudré A, Ferreira I, Lefkopoulos D. Quality assurance of a virtual simulation software: application to IMAgo and SIMAgo (ISOgray). Article in French. Cancer Radiother. 2007;11(4):178-187.
Veres C, Allodji RS, Llanas D, et al. Retrospective reconstructions of active bone marrow dose-volume histograms. Int J Radiat Oncol Biol Phys. 2014;90(5):1216-1224.
Badouna ANI, Veres C, Haddy N, et al. Total heart volume as a function of clinical and anthropometric parameters in a population of external beam radiation therapy patients. Phys Med Biol. 2012;57(2):473-484.
Heude B, Scherdel P, Werner A, et al. A big-data approach to producing descriptive anthropometric references: a feasibility and validation study of paediatric growth charts. Lancet Digit Health. 2019;1(8):e413-e423.
Zhang FF, Parsons SK. Obesity in childhood cancer survivors: call for early weight management. Adv Nutr. 2015;6(5):611-619.
Diller L, Chow EJ, Gurney JG, et al. Chronic disease in the Childhood Cancer Survivor Study: a review of published findings. J Clin Oncol. 2009;27(14):2339-2355.
Murphy-Alford AJ, White M, Lockwood L, Hallahan A, Davies PSW. Body composition, dietary intake and physical activity of young survivors of childhood cancer. Clin Nutr. 2019;38(2):842-847.
Wilson CL, Liu W, Yang JJ, et al. Genetic and clinical factors associated with obesity among adult survivors of childhood cancer: a report from the St. Jude lifetime cohort. Cancer. 2015;121(13):2262-2270.
Oeffinger KC, Mertens AC, Sklar CA, et al. Obesity in adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2003;21(7):1359-1365.
van Santen HM, Chemaitilly W, Meacham LR, Tonorezos ES, Mostoufi-Moab S. Endocrine health in childhood cancer survivors. Pediatr Clin North Am. 2020;67(6):1171-1186.
Lindemulder SJ, Stork LC, Bostrom B, et al. Survivors of standard risk acute lymphoblastic leukemia do not have increased risk for overweight and obesity compared to non-cancer peers: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2015;62(6):1035-1041.
Brouwer CAJ, Gietema JA, Vonk JM, et al. Body mass index and annual increase of body mass index in long-term childhood cancer survivors; relationship to treatment. Support Care Cancer. 2012;20(2):311-318.
Mostoufi-Moab S, Seidel K, Leisenring WM, et al. Endocrine abnormalities in aging survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2016;34(27):3240-3247.
Shah SS, Dellarole A, Peterson EC, et al. Long-term psychiatric outcomes in pediatric brain tumor survivors. Childs Nerv Syst. 2015;31(5):653-663.
Turner CD, Rey-Casserly C, Liptak CC, Chordas C. Late effects of therapy for pediatric brain tumor survivors. J Child Neurol. 2009;24(11):1455-1463.
Doger de Spéville E, Kieffer V, Dufour C, et al. Neuropsychological consequences of childhood medulloblastoma and possible interventions: a review. Neurochirurgie. 2021;67(1):90-98.
Liou TH, Pi-Sunyer FX, Laferrère B. Physical disability and obesity. Nutr Rev. 2005;63(10):321-331.
Wrzesińska M, Lipert A, Urzędowicz B, Pawlicki L. Self-reported physical activity using international physical activity questionnaire in adolescents and young adults with visual impairment. Disabil Health J. 2018;11(1):20-30.
Segal M, Eliasziw M, Phillips S, et al. Intellectual disability is associated with increased risk for obesity in a nationally representative sample of U.S. children. Disabil Health J. 2016;9(3):392-398.
Dumas A, Berger C, Auquier P, et al. Educational and occupational outcomes of childhood cancer survivors 30 years after diagnosis: a French cohort study. Br J Cancer. 2016;114(9):1060-1068.
Wang KW, Fleming A, Johnston DL, et al. Overweight, obesity and adiposity in survivors of childhood brain tumours: a systematic review and meta-analysis. Clin Obes. 2018;8(1):55-67.
Cooksey R, Wu SY, Klesse L, et al. Metabolic syndrome is a sequela of radiation exposure in hypothalamic obesity among survivors of childhood brain tumors. J Investig Med. 2019;67(2):295-302.
Casazza K, Fontaine KR, Astrup A, et al. Myths, presumptions, and facts about obesity. N Engl J Med. 2013;368(5):446-454.
Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med. 1997;337(13):869-873.
Haute Autorité de Santé. Guide du parcours de soins: Surpoids et obésité de l'enfant et de l'adolescent Published February 3, 2022. Updated February 16, 2023. https://www.has-sante.fr/jcms/c_964941/fr/surpoids-et-obesite-de-l-enfant-et-de-l-adolescent-actualisation-des-recommandations-2003
Ancona-Lezama D, Dalvin LA, Shields CL. Modern treatment of retinoblastoma: a 2020 review. Indian J Ophthalmol. 2020;68(11):2356-2365.